A unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses

Hyun, Jinhee; Kanagavelu, Saravana; Fukata, Masayuki

doi:10.1016/j.micinf.2012.10.011

Cited by 27 publications

(21 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analysis of autosomal dominant-negative mutations and SNPs has identified TRIF-dependent signaling as a key component of antiviral defense in humans. Although TRIFmediated TLR3 signaling is generally associated with host defense against dsRNA viruses, it is also important for resistance to infection with DNA viruses and ssRNA viruses [143].…”

Section: Trif-dependent Antiviral Responsesmentioning

confidence: 99%

TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

Ullah

Sweet

Mansell

et al. 2016

Journal of Leukocyte Biology

154

108

View full text Add to dashboard Cite

Toll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF)-dependent signaling is required for TLR-mediated production of type-I IFN and several other proinflammatory mediators. Various pathogens target the signaling molecules and transcriptional regulators acting in the TRIF pathway, thus demonstrating the importance of this pathway in host defense. Indeed, the TRIF pathway contributes to control of both viral and bacterial pathogens through promotion of inflammatory mediators and activation of antimicrobial responses. TRIF signaling also has both protective and pathologic roles in several chronic inflammatory disease conditions, as well as an essential function in wound-repair processes. Here, we review our current understanding of the regulatory mechanisms that control TRIF-dependent TLR signaling, the role of the TRIF pathway in different infectious and noninfectious pathologic states, and the potential for manipulating TRIF-dependent TLR signaling for therapeutic benefit.

show abstract

Section: Trif-dependent Antiviral Responsesmentioning

confidence: 99%

TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

Ullah

Sweet

Mansell

et al. 2016

Journal of Leukocyte Biology

154

108

View full text Add to dashboard Cite

show abstract

“…In piscine cells, both fugu Takifugu rubripes TLR3 (fgTLR3) and fgTLR22 employ the TRIF adaptor to induce IFN responses upon virus infection (Oshiumi et al, 2003;Matsuo et al, 2008). TRIF provides early clearance of viral and bacterial pathogens (Hyun et al, 2013). Mammalian TRIF consists of N-terminal region, TIR-domain and C-terminal region.…”

Section: Introductionmentioning

confidence: 99%

Identification and functional characterizations of a novel TRIF gene from grass carp (Ctenopharyngodon idella)

Yang

et al. 2013

Developmental & Comparative Immunology

View full text Add to dashboard Cite

“…By interacting with upstream adaptors, TRIF undergoes conformational changes and recruits the downstream TNF receptor-associated factor (TRAF)3 and TRAF6 [reviewed in Ref. (35)]. The kinase receptor-interacting protein-1 (RIP-1) is part of both the signaling pathways downstream of TLR3 and RIG-I.…”

mentioning

confidence: 99%

Viral Evasion Strategies in Type I IFN Signaling – A Summary of Recent Developments

2016

View full text Add to dashboard Cite

The immune system protects the organism against infections and the damage associated with them. The first line of defense against pathogens is the innate immune response. In the case of a viral infection, it induces the interferon (IFN) signaling cascade and eventually the expression of type I IFN, which then causes an antiviral state in the cells. However, many viruses have developed strategies to counteract this mechanism and prevent the production of IFN. In order to modulate or inhibit the IFN signaling cascade in their favor, viruses have found ways to interfere at every single step of the cascade, for example, by inducing protein degradation or cleavage, or by mediate protein polyubiquitination. In this article, we will review examples of viruses that modulate the IFN response and describe the mechanisms they use.

show abstract

A unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses

Cited by 27 publications

References 74 publications

TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

Identification and functional characterizations of a novel TRIF gene from grass carp (Ctenopharyngodon idella)

Viral Evasion Strategies in Type I IFN Signaling – A Summary of Recent Developments

Contact Info

Product

Resources

About