A unique case of an indolent CD56-positive T-cell lymphoproliferative disorder of the gastrointestinal tract: a lesion potentially misdiagnosed as natural killer/T-cell lymphoma

McElroy, Michele; Read, William; Harmon, Gregory S.; Weidner, Noel

doi:10.1016/j.anndiagpath.2010.05.007

Cited by 26 publications

(33 citation statements)

References 12 publications

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“…Vega et al first described an indolent NK‐cell LPD of the GI tract in 2006 . Since then, two case series and sporadic reports have further characterized 24 cases of indolent NK‐cell LPDs restricted to the GI tract, which have been variably designated ‘lymphomatoid gastropathy’ or ‘NK‐cell enteropathy’ (Table ) . Cases of lymphomatoid gastropathy were described in middle aged or older Japanese individuals (median age—56 years, range 46–75 years) without significant gender predilection (M:F—0.9:1) .…”

Section: Indolent Nk‐cell Lpds Of the Gi Tractmentioning

confidence: 99%

“…Cases of lymphomatoid gastropathy were described in middle aged or older Japanese individuals (median age—56 years, range 46–75 years) without significant gender predilection (M:F—0.9:1) . Meanwhile, cases of NK‐cell enteropathy were reported from the United States and Korea, the median age at diagnosis being 46 years (range 14–68 years), and a female predominance was observed (M:F—0.6–1) . A case of CD56+ T‐cell LPD reported by McElroy et al has been included in this category as the described clinicopathological and molecular features were suggestive of NK‐cell enteropathy .…”

Section: Indolent Nk‐cell Lpds Of the Gi Tractmentioning

confidence: 99%

“…Over the past couple of decades, sporadic case reports and limited series have described primary gastrointestinal T‐ and NK‐cell proliferations, variably termed indolent lymphomas or lymphoproliferative disorders (LPDs) . Recent, well‐characterized case series from the United States, Europe and Japan have provided greater insight into the clinical, histopathologic and phenotypic spectrum of these LPDs .…”

Section: Introductionmentioning

confidence: 99%

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Indolent T‐ and NK‐cell lymphoproliferative disorders of the gastrointestinal tract: a review and update

Matnani

Ganapathi

Lewis

et al. 2016

Hematological Oncology

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Primary gastrointestinal (GI) T-and NK-cell lymphomas are usually aggressive neoplasms associated with high morbidity and mortality. Over the past two decades, however, cases of primary GI lymphoproliferative disorders (LPDs) or lymphomas of T-or NK-cell derivation with indolent behavior have been reported. These LPDs are rare and they can be challenging to diagnose as they share clinical and pathological features with both, inflammatory disorders and aggressive T-and NK-cell lymphomas. Primary, indolent clonal T-cell proliferations of the GI tract, which can be CD4+, CD8+ or CD4À CD8À, have been included as a provisional entity in the newly revised World Health Organization (WHO) classification of lymphoid neoplasms and designated 'indolent T-cell LPD of the GI tract'. It is currently unclear whether the indolent NK-cell LPDs represent reactive or neoplastic proliferations. In this review, we describe the clinical, morphologic, immunophenotypic and genetic features of indolent GI T-and NK-cell LPDs and provide guidance in differentiating them from other inflammatory and neoplastic diseases. We believe that greater awareness of these LPDs amongst physicians and the research community will lead to timely and accurate diagnoses, stimulate investigations into the pathogenetic mechanisms underlying different entities thereby enhancing our understanding of disease biology and enable the development of effective therapeutic regimens.

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Section: Indolent Nk‐cell Lpds Of the Gi Tractmentioning

confidence: 99%

Section: Indolent Nk‐cell Lpds Of the Gi Tractmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Indolent T‐ and NK‐cell lymphoproliferative disorders of the gastrointestinal tract: a review and update

Matnani

Ganapathi

Lewis

et al. 2016

Hematological Oncology

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“…Furthermore, antigliadin antibody Igm and IgG serology and endomysial antibody tests were also negative. The nasal type of the extranodal NK/T-cell lymphoma occurs usually in the nasopharyngeal region; it is CD56 positive CD8 negative, lacks usually T cell receptor (TCr) gene rearrangement, and is strongly associated with EBV (1,(25)(26)(27). It is described as ''NK/T ''rather than ''NK'' because of some reported cases in which cytotoxic T-cell phenotype was observed (1,14).…”

Section: Case Reportmentioning

confidence: 99%

“…Patients usually present at an advanced stage with peritonitis as a result of tumor perforation (24). NK/T-cell lymphomas are reported in a few studies as case series and the true incidence is probably more frequent than expected (26,27). Furthermore, NK/Tcell lymphoma of the terminal ileum can mimic Behçet's enteritis or intestinal tuberculosis and should be considered in the differential diagnosis of these diseases.…”

Section: Case Reportmentioning

confidence: 99%

Natural killer-like t-cell lymphoma localized to the terminal ileum: case report

Bayol¹,

Cumurcu²,

Karaman³

et al. 2013

TJPATH

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Intestinal intraepithelial lymphocytes are non-organized lymphoid populations that are composed of heterogeneous subsets with diverse ontogeny and phenotypes, and the differential diagnosis is crucial. A 43-year-old male patient underwent an emergency laparotomy due to a perforated mass of the terminal ileum. A right hemicolectomy plus small bowel resection was performed. Histopathological examination showed medium to large cells with vesicular nuclei, including marked nucleoli with large, colorless cytoplasm. No signs of celiac disease were found in the adjacent mucosa. The tumor cells were immunohistochemically CD45+, CD3+, CD4+, CD8+, CD56+, Pan-Cytokeratin-, CD20-, CD79a-, CD5-and CD30-. Endomysial antibody and antigliadin antibody, Igm and IgG tests; and anti-Ebstein Barr virus latent membrane protein all proved negative. Finally, the histopathological diagnosis of tumor mass was natural killer-like T-cell lymphoma. Primary intestinal cytotoxic natural killer-like T-cell lymphoma is a rare entity, which is difficult to distinguish from other T-cell lymphomas. In addition to microscopic evaluation, immunohistochemical analysis and serological tests are essential to reach a definitive diagnosis.

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2021

Flow Cytometry of Hematological Malignancies

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A unique case of an indolent CD56-positive T-cell lymphoproliferative disorder of the gastrointestinal tract: a lesion potentially misdiagnosed as natural killer/T-cell lymphoma

Cited by 26 publications

References 12 publications

Indolent T‐ and NK‐cell lymphoproliferative disorders of the gastrointestinal tract: a review and update

Indolent T‐ and NK‐cell lymphoproliferative disorders of the gastrointestinal tract: a review and update

Natural killer-like t-cell lymphoma localized to the terminal ileum: case report

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