A unified theory for osteonal and hemi-osteonal remodeling

Oers, René F.M. van; Ruimerman, R Ronald; Tanck, E.; Hilbers, P.A.J.; Huiskes, R.

doi:10.1016/j.bone.2007.10.009

Cited by 149 publications

(100 citation statements)

References 49 publications

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“…Later studies have explicitly modeled osteoclasts resorbing lacunae of several elements (van Oers et al 2008), or lacunae with an explicit shape and size of several elements (Liu et al 2008). Although it would be possible to use the latter models here, we believe it would not offer any advantages for the present research goals.…”

Section: Discussionmentioning

confidence: 99%

“…An alternative version of Huiskes' model had osteoclast activity inhibited by strain-induced osteocyte signals, and this was also central to our extended version of the model (van Oers et al 2008), where osteoclasts were explicitly modeled and guided by osteocyte signals. In this study we have chosen for random resorption, however, to ensure that any adaptation to mechanical loading is the result of osteocyte-osteoblast crosstalk.…”

Section: The Stimulatory Modelmentioning

confidence: 99%

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A sclerostin-based theory for strain-induced bone formation

Oers

Rietbergen

Ito

et al. 2010

Biomech Model Mechanobiol

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Bone formation responds to mechanical loading, which is believed to be mediated by osteocytes. Previous theories assumed that loading stimulates osteocytes to secrete signals that stimulate bone formation. In computer simulations this 'stimulatory' theory successfully produced loadaligned trabecular structures. In recent years, however, it was discovered that osteocytes inhibit bone formation via the protein sclerostin. To reconcile this with strain-induced bone formation, one must assume that sclerostin secretion decreases with mechanical loading. This leads to a new 'inhibitory' theory in which loading inhibits osteocytes from inhibiting bone formation. Here we used computer simulations to show that a sclerostin-based model is able to produce a load-aligned trabecular architecture. An important difference appeared when we compared the response of the stimulatory and inhibitory models to loss of osteocytes, and found that the inhibitory pathway prevents the loss of trabeculae that is seen with the stimulatory model. Further, we demonstrated with combined stimulatory/inhibitory models that the two pathways can work side-by-side to achieve a load-adapted bone architecture.

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Section: Discussionmentioning

confidence: 99%

Section: The Stimulatory Modelmentioning

confidence: 99%

A sclerostin-based theory for strain-induced bone formation

Oers

Rietbergen

Ito

et al. 2010

Biomech Model Mechanobiol

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“…Most important, this autologous product eliminates concerns about immunogenic reactions and disease transmission (42). Histomorphometry of cancellous bone is a useful tool to estimate changes in bone remodeling because approximately 25% of cancellous bone is resorbed and replaced every year in adults compared to only 3% reduction in cortical bone and this explains why in most of papers focused more on cancellous bone (43). The histomorphometric results in the present study revealed that defects grafted with ASCs-PRP showed a significantly higher result (p≤0.05), with a mean area % of spongy bone and compact bone of (64.96±5.37 and 837.62±24.95), compared to ASCs alone (47.65±1.43 and 661.92±12.65) and without grafting (33.55±1.74 and 290.85±7.27) respectively.…”

Section: Discussionmentioning

confidence: 99%

Influence of Autologus Adipose Derived Stem Cells and PRP on Regeneration of Dehiscence-Type Defects in Alveolar Bone: A Comparative Histochemical and Histomorphometric Study in Dogs

Aly

Menoufy²,

Hassan³

et al. 2011

Int J Stem Cells

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Background and Objectives: Autogenous bone grafts is considered to be the best choice for reconstructive surgery. Adipose Derived Stromal Cells (ASCs) represents a promising tool for new clinical concepts in supporting cellular therapy. The goal of our study was to investigate bone regeneration following application of autologous ASCs with or without Platelet-Rich Plasma (PRP) at dehiscence-type defects in alveolar bone in dogs. Methods and Results: Standardized buccal dehiscence defects (4×3×3 mm) were surgically created in eighteen dogs, the defects were grafted with either ASCs -PRP, ASCs alone, or without grafting material. Three months later; a bone core was harvested from grafted and non grafted sites for histological, histochemical and histomorphometric assessment. There was no evidence of inflammation or adverse tissue reaction with either treatment. Defects grafted with ASCs-PRP showed a significantly higher result (p≤0.05), with a mean area % of spongy bone and compact bone of (64.96±5.37 and 837.62±24.95), compared to ASCs alone (47.65±1.43 and 661.92±12.65) and without grafting (33.55±1.74 and 290.85±7.27) respectively. The area % of lamellated bone increased significantly reaching its highest level in group A followed by group B. Also a significant increase in area % of neutral mucopolysaccharides and calcified reactivity of Masson's Trichrome stain in groups A and B compared to group C was obtained. Conclusions: Our results suggest that, the addition of PRP to ASCs enhances bone formation after 3 months and may be clinically effective in accelerating postsurgical healing in both periodontal and maxillofacial surgical applications.

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“…This choice was made to stay in agreement with the remodeling theory used in earlier numerical studies [15]. It should be noted, however, that it would be straightforward to also make osteoclast activity dependent on the mechanical signal, but in earlier studies this did not lead to large differences in the result [50]. Third, as in these earlier studies, we used strain energy density as the mechanical stimulus, whereas others have proposed other stimuli such as fluid flow and microdamage [11,51].…”

Section: Discussionmentioning

confidence: 99%