A unified nomenclature for peroxisome biogenesis factors.

Distel, Ben; Erdmann, Ralf; Gould, Stephen J.; Blobel, G.; Crane, Denis I.; Cregg, James M.; Dodt, Gabriele; Fujiki, Yukio; Goodman, Joel M.; Just, Wilhelm W.; Kiel, Jan A.K.W.; Kunau, Wolf‐H.; Lazarow, Paul B.; Mannaerts, Guy P.; Moser, Hugo W.; Osumi, Takashi; Rachubinski, Richard A.; Roscher, Adelbert A.; Subramani, Suresh; Tabak, Henk F.; Tsukamoto, Tomoko; Valle, David; Klei, Ida J. van der; Veldhoven, Paul P. Van; Veenhuis, Marten

doi:10.1083/jcb.135.1.1

Cited by 364 publications

(211 citation statements)

References 47 publications

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“…This possibility was excluded by examining the ability of cells totally lacking peroxisomes to sporulate on this medium type. S. cerevisiae ⌬pex6 (formerly pas8; Voorn-Brouwer et al, 1993;Distel et al, 1996) mutant cells (yAG176) are devoid of peroxisomes showing no detectable peroxisomal structures. The homozygous ⌬pex6 diploid strain sporulated to wild-type levels of over 50% on solid medium containing acetate, and we therefore reasoned that, in S. cerevisiae, meiotic development takes place in the total absence of peroxisomal structures that may contain an intact ␤-oxidation system.…”

Section: Pip2p and Oaf1p Are Not Required For Sporulationmentioning

confidence: 99%

Regulation of the yeast SPS19 gene encoding peroxisomal 2,4‐dienoyl‐CoA reductase by the transcription factors Pip2p and Oaf1p: β‐oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium

Gurvitz

Rottensteiner

et al. 1997

Molecular Microbiology

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SummaryThe yeast SPS19 gene encoding the peroxisomally targeted 2,4-dienoyl-CoA reductase shares its promoter region (291 bp) with the sporulation-specific gene SPS18. SPS19 is induced during sporulation in diploids but to a lesser extent than SPS18 ; under oleate induction conditions, SPS19, but not SPS18, is transcribed via an oleate response element (ORE) independently of ploidy or sporulation. The SPS19 ORE is the binding target of the Pip2p and Oaf1p transcription factors, and an SPS19-lacZ reporter gene, which is highly expressed in oleate-induced cells, is not activated in haploids devoid of either protein.We examined the expression of CYC1-lacZ reporter constructs carrying the SPS19 and CTA1 OREs in diploids propagated under sporulation conditions and have shown that OREs are not sufficient for heterologous expression during yeast development. In addition, diploids deleted at either PIP2 or OAF1 demonstrated abundant ascosporogenesis, indicating that these genes are not essential for sporulation. A ⌬pex6 strain lacking peroxisomal structures and one devoid of fatty acyl-CoA oxidase (⌬pox1), the first step in fungal ␤-oxidation, were both proficient for sporulation and, hence, ␤-oxidation and the peroxisomal compartment containing it are dispensable for meiotic development.

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Section: Pip2p and Oaf1p Are Not Required For Sporulationmentioning

confidence: 99%

Regulation of the yeast SPS19 gene encoding peroxisomal 2,4‐dienoyl‐CoA reductase by the transcription factors Pip2p and Oaf1p: β‐oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium

Gurvitz

Rottensteiner

et al. 1997

Molecular Microbiology

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“…4). Pex11p may function as a peroxisome biogenesis regulator, possibly by interacting with other PEX proteins [2,3,18], including RING peroxins, Pex2p [13,22,46] and Pex12p [15,16,27], AAA family peroxins Pex1p [17,19,20] and Pex6p [14,25,26], a tetratricopeptide repeat (TPR) protein Pex5p (PTS1 receptor) [23,24,47], a WD motif protein Pex7p (PTS2 receptor) [48^50], and Pex13p (PTS1 receptor docking protein) presumed in mammals [51]. Functional role of Pex11p in peroxisome biogenesis in mammals remains to be investigated.…”

Section: Intracellular Localization and Topology Of Pex11pmentioning

confidence: 99%

“…Peroxisomes are formed by division of preexisting peroxisomes after posttranslational import of newly synthesized proteins [1]. Genetic analysis of peroxisome-de¢cient mutants of yeast and mammalian cells have led to identi¢cation of a number of protein factors essential for peroxisome biogenesis [2,3]. Genetical heterogeneities comprising 12 complementation groups (CGs) have been identi¢ed in mammals, including humans [4^12].…”

Section: Introductionmentioning

confidence: 99%

Clofibrate‐inducible, 28‐kDa peroxisomal integral membrane protein is encoded by PEX11

et al. 1998

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We cloned a human PEX11 cDNA by expressed sequence tag homology search using yeast Candida boidinii PEX11, followed by screening of human liver cDNA library. PEX11 encoded a peroxisomal protein Pex11p comprising 247 amino acids, with two transmembrane segments and a dilysine motif at the C-terminus. Pex11p comigrated in SDS-PAGE with a 28-kDa peroxisomal integral membrane protein (PMP28) isolated from the liver of clofibrate-treated rats and was crossreactive to anti-PMP28 antibody, thereby indicating PEX11 to encode PMP28. Pex11p exposes both N-and Cterminal parts to the cytosol. PEX11 was not responsible for ten complementation groups of human peroxisome deficiency disorders.z 1998 Federation of European Biochemical Societies.

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“…Two distinct topogenic signals, peroxisomal targeting signal type 1 (PTS1) and PTS2 (16,40), direct proteins to the peroxisomal matrix. Genetic analyses of peroxisome-deficient mutants isolated from yeast and mammalian cells led to the identification of a number of proteins, known as peroxins, which are essential for peroxisome biogenesis (11,17,23,41). PEX5 and PEX7 encode the receptors for PTS1 and PTS2, respectively.…”

mentioning

confidence: 99%

Peroxisomal Targeting Signal Receptor Pex5p Interacts with Cargoes and Import Machinery Components in a Spatiotemporally Differentiated Manner: Conserved Pex5p WXXXF/Y Motifs Are Critical for Matrix Protein Import

Otera

Setoguchi

Hamasaki

et al. 2002

Molecular and Cellular Biology

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282

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A unified nomenclature for peroxisome biogenesis factors.

Cited by 364 publications

References 47 publications

Regulation of the yeast SPS19 gene encoding peroxisomal 2,4‐dienoyl‐CoA reductase by the transcription factors Pip2p and Oaf1p: β‐oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium

Regulation of the yeast SPS19 gene encoding peroxisomal 2,4‐dienoyl‐CoA reductase by the transcription factors Pip2p and Oaf1p: β‐oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium

Clofibrate‐inducible, 28‐kDa peroxisomal integral membrane protein is encoded by PEX11

Peroxisomal Targeting Signal Receptor Pex5p Interacts with Cargoes and Import Machinery Components in a Spatiotemporally Differentiated Manner: Conserved Pex5p WXXXF/Y Motifs Are Critical for Matrix Protein Import

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