A type‐specific study of human papillomavirus prevalence in cervicovaginal samples in three different Spanish regions

Abstract

Human papillomavirus (HPV) is the most frequent sexually transmitted viral infection. It is necessary to know HPV genotype distribution to identify how many women will be protected by HPV vaccines. During a period of 18 months, we have analyzed 2362 HPV positive reporting data from a secondary demand screening program in three regions in Spain (Cantabria, Leon and Burgos). The study has been conducted using polymerase chain reaction and tube array hybridization covering the 35 HPV genotypes described as affecting anogenital mucosa. There were no significant differences between the three regions according to genotype distribution. The most frequent were HPV16 (19.18%), HPV53 (11.26%) and HPV58 (7.66%). HPV18 was the source of 4.02% of infections. High-risk HPVs were found in 1863/2362 cases. HPV16 was present in 24.3% of high-risk infections and HPV18 was found in 5.1%. Uncommon genotypes (<5% of the total prevalence each) were found in 17,9% of the total high-risk infections (334/1863). Multiple infections were diagnosed in 22% of the cases. The HPV genotype distribution is different from previously published data when multiple types are included in the screening. Both HPV16/18 account for 30% of high-risk infections in a clinical setting in Spain. The presence of multiple genotypes is very common among the population.

Prevalence of Human Papillomavirus (HPV) Genotypes and Multiple Infections in Routine Cervical Cancer Screening in a Spanish Regional Population

“…Our results fall within this range. This prevalence of multiple HPV infection is higher than found in other studies conducted in Spain in which the values range between 4.7% and 52.1% [6,29,30,34,36,38,57]. Furthermore, in a study of patients with abnormal cytology obtained a higher value (58.1%) [35] than found in this study.…”

Cervical infection associated with human papillomavirus types 52, 58, and 59

“…Изменение эпидемиологической ситуации в отноше-нии ВПЧ наряду с изменением в последние годы структу-ры CIN [1,6,18,19] диктует необходимость продолжения изучения распространенности и роли типов ВПЧ, облада-ющих высоким онкогенным потенциалом, при CIN. Дан-ные по исследованию частоты выявления «азиатских» ти-пов ВПЧ ВР, включая 52-й и 58-й типы, их роли в разви-тии предраковых заболеваний шейки матки в популяции женского населения России немногочисленны.…”

Association of polymorphism in FcGR3A gene and progression of low-grade precursor lesions of cervical carcinoma

“…Genotyping was performed with Clart HPV 2 kit according to manufacturer's instructions (Genomica, Madrid, Spain; ClonDiag, Jena, Germany) [12,14]. HPV types genotyped with the kit included HR-HPV genotypes 16 …”