A two-method meta-analysis of Neuregulin 1(NRG1) association and heterogeneity in schizophrenia

Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?

“…Similarly, endophenotype studies exploring both functional and structural deficits of psychosis have failed to find any associations with COMT and BDNF (Bramon et al 2006 ;Dutt et al 2009). Recent metaanalyses and an association study concluded that NRG1 markers do not contribute significantly to schizophrenia (Gong et al 2009 ;Jonsson et al 2009). Despite the negative findings, there have been many positive reports of an association replicating NRG1 as a candidate gene for psychosis (Stefansson et al 2002(Stefansson et al , 2003(Stefansson et al , 2004Lewis et al 2003 ;Williams et al 2003 ;Li et al 2006 ;Georgieva et al 2008 ;Munafo et al 2008 ;Sanders et al 2008 ;Prata et al 2009).…”

Neuregulin-1 and schizophrenia in the genome-wide association study era

“…Results of these studies are mixed but suggest a significant association between 5' NRG1 genetic variation and schizophrenia. The largest and most recent analysis (Gong et al 2009) showed support for three (SNP8NRG221132, 478B14-848, 420M9-1395) of the seven HAP ICE markers when combining case-control and family studies across ancestry. While, Munafo and colleagues (Munafo et al 2006) (Munafo et al, 2008) showed support at the haplotype level using a combined p-value approach, others have argued that this approach should be extended to the gene level as this would address, in part, the allelic heterogeneity within NRG1 between populations (Neale and Sham 2004).…”

Contribution of nonprimate animal models in understanding the etiology of schizophrenia

“…266 Another recent meta-analysis also found several polymorphisms of NRG1 that were significantly associated with the development of schizophrenia. 267 Interestingly, some haplotypes have been associated with the deficit form of schizophrenia, whereas others have been associated with the nondeficit form of schizophrenia. 261 Again, as with the results of COMT, the various haplotypes associated with schizophrenia are not always consistent across studies, and no endophenotypes have been associated with this gene as of yet.…”