A tutorial and mini-review of the ICP-MS technique for determinations of transition metal ion and main group element concentration in the neurodegenerative and brain sciences

Ha, Yonghwang; Tsay, Olga G.; Churchill, David G.

doi:10.1007/s00706-010-0438-6

Cited by 25 publications

(17 citation statements)

References 75 publications

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“…Since the procedure involved elution of protein from the magnetic bead-antibody construct by citric acid, it was feasible to directly perform analysis of the protein fraction by inductively coupled plasma mass spectrometry (ICP-MS), which is a method for elemental analysis of liquid samples [20]. The detection of metals bound to proteins is straightforward with ICP-MS since buffers and the polypeptide chemistry do not contain metal ions [21]; in case of CisPt, the Pt element is detected and no conclusion regarding its ligation can be drawn.…”

Section: Figurementioning

confidence: 99%

Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells

Palm-Espling¹,

Lundin²,

Björn³

et al. 2013

PPL

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Section: Figurementioning

confidence: 99%

Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells

Palm-Espling¹,

Lundin²,

Björn³

et al. 2013

PPL

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“…In this study, we provide re-determined values of the molar absorption coefficients and stability constants that are valid for various experimental conditions. [50]. All of the pH buffers used in this study were treated with Chelex-100 resin to eliminate trace metal ion contamination [51][52][53].…”

Section: Introductionmentioning

confidence: 99%

Molar absorption coefficients and stability constants of metal complexes of 4-(2-pyridylazo)resorcinol (PAR): Revisiting common chelating probe for the study of metalloproteins

Kocyła

Pomorski

Krężel

2015

Journal of Inorganic Biochemistry

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“…Taking into account the literature data [27,28], an ICP-MS method and inductively coupled plasma optical emission spectrometry (ICP-OES) can be distinguished among other analytical techniques as a powerful tool in multielemental analysis in a wide range of concentrations, with high sensitivity, short time of analysis, and low limits of quantitation. Applications of ICP-MS and ICP-OES have been reported for the wide range of biological and clinical samples, both fluids (blood [29], amniotic fluid [30], and cerebrospinal fluid [31]) and solid tissues [31][32][33][34][35][36]. Complex matrices of clinical samples are often a source of interferences caused by monoatomic and polyatomic ions, formed in the plasma from the matrix constituents.…”

Section: Chemical Analysis Of Prostate Gland Elemental Contentmentioning

confidence: 99%

ICP-MS analysis of diet supplementation influence on the elemental content of rat prostate gland

et al. 2019

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Metabolism of numerous elements is involved in carcinogenesis. Among other, calcium and zinc metabolic pathways coincide with prostate cancer development. It is probable that the restoration of elemental loses can moderate or even stop prostate malignancy. For this reason, studies on elemental content in tissues taken from organisms with cancer are carried out to establish proper supplementation. ICP-MS is a well-established method for the analysis of such a kind of samples. The study aimed to investigate the influence of dietary supplementation on elemental content in the prostate gland of rats with implanted cancer cells. Tested animals were divided into six dietary groups: standard diet and supplementation with Ca, Fe, Zn, Cu, or Se. Every dietary group was divided into experimental group (with implanted cancer cells) and control group (without cancer cells). Prostate tissue was dried and treated with microwave-assisted mineral digestion. Total elemental content was quantified by ICP-MS. Student's t test and analysis of variance with post-hoc Tukey's procedure were applied to compare treatment and dietary groups. The total content of selected elements (K, Na, Mg, Ca, Fe, Zn, Cu, Sr, Pb, and Se) was quantified, with statistically significant differences in Na, Mg, Ca, Zn, Sr, and Se contents between treatment groups and in Ca, Fe, Cu, Zn, Sr, and Pb contents between diet groups. High heterogeneity within group could be observed for Zn content in the tissue, confirming the crucial role of zinc in prostate gland metabolism and pointing its inter-individual variability. Graphic abstractKeywords Alkali metals · Antitumor agents · Inductively coupled plasma mass spectrometry · Transition metal compounds * Agata Jagielska

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A tutorial and mini-review of the ICP-MS technique for determinations of transition metal ion and main group element concentration in the neurodegenerative and brain sciences

Cited by 25 publications

References 75 publications

Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells

Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells

Molar absorption coefficients and stability constants of metal complexes of 4-(2-pyridylazo)resorcinol (PAR): Revisiting common chelating probe for the study of metalloproteins

ICP-MS analysis of diet supplementation influence on the elemental content of rat prostate gland

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