A turn-on fluorescent probe for cyanide based on aggregation of terthienyl and its application for bioimaging

Sun, Yue; Li, Ying; Ma, Xiaotao; Duan, Lian

doi:10.1016/j.snb.2015.10.057

Cited by 34 publications

(18 citation statements)

References 25 publications

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“…The official methods of determining cyanides include titration [51,52], spectrophotometry [65,66], potentiometry with cyanide-selective electrodes [51,53], flow injection (FI)-amperometry [54]. Analysis of cyanide in various matrices including water, soil, air, exhaled breath, food, and biological fluids (blood, urine, saliva, etc.…”

Section: Sensing Mechanisms and Synthesis Of Cyanide Sensors (Cs)mentioning

confidence: 99%

“…Sun et al [65] have prepared a turn-on fluorescent probe CS1 based on terthienyl for the detection of cyanide through the aggregation-induced emission (AIE) behavior of terthienyl units in aqueous solutions (Scheme 1). They confirmed the AIE behavior of CS1 using the dynamic light scattering (DLS) measurements and the scanning electron microscopy (SEM) studies.…”

Section: Cyanide Sensing Via Aggregation Induced Emission (Aie)mentioning

confidence: 99%

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Fluorescence Dyes for Determination of Cyanide

Yahaya¹,

Seferoğlu²

2018

Photochemistry and Photophysics - Fundamentals to Applications

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Cyanides being highly poisonous to living beings and pollutants to our environment are among the most important anions studied over the years. As cyanide usage continues to sky-rocket, it is extremely important and high time that chemists devised methods for their detection to ensure harmless usage and safer working conditions for people coming into contact with cyanide and its compounds, day in day out. In this book, an attempt has been made to provide an in-depth commentary of literature for the synthesis of fluorescent dyes and mechanisms for the molecular recognition and detection of cyanide ions. It also covers some current entropy on colorimetric and fluorescent organic chemical probes for the detection and quantification of cyanide anions via fluorogenic and chromogenic procedures.

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Section: Sensing Mechanisms and Synthesis Of Cyanide Sensors (Cs)mentioning

confidence: 99%

Section: Cyanide Sensing Via Aggregation Induced Emission (Aie)mentioning

confidence: 99%

Fluorescence Dyes for Determination of Cyanide

Yahaya¹,

Seferoğlu²

2018

Photochemistry and Photophysics - Fundamentals to Applications

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“…[19][20][21] To date, a great number of AIE-based "turn-on" biosensors have been reported to target proteins, nucleic acids and glucose with superior sensitivity. [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] Recently, some AIE-based probes to detect specific enzymes such as Caspases, MMPs, ACE and SIRTs were reported and opened new opportunities for bioprobe design with optimized performance. [38][39][40][41][42][43] However, interestingly, there are no reports concerning its utilization in the lipase activity assay.…”

Section: 113) Are Versatile Biocatalysts That Can Catalyze Varioumentioning

confidence: 99%

A novel fluorometric turn-on assay for lipase activity based on an aggregation-induced emission (AIE) luminogen

Shi

Zhang

Zheng

et al. 2017

Sensors and Actuators B: Chemical

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Lipase plays critical roles in the industrial catalysis, drug discovery and medical diagnosis of diseases. In this paper, based on the consideration that a tetraphenylethylene (TPE) derivative P1 with a-COOC 6 H 13 group can be hydrolyzed into TPE-COOH which shows low solubility in same solutions and thus aggregation can occur easily, a novel fluorescence turn-on probe bearing aggregation-induced emission (AIE) characteristics to rapidly visualize lipase activities has been constructed with compound P1. Lipase of concentrations as low as 0.1 mg mL-1 can be detected and the assay range of lipase was located in 0.1-1.3 mg mL-1. On the other hand, the selectivity of probe P1, dynamic monitoring of enzymatic reaction and preliminary commercially enzyme activity screening was also summarized.

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“…In biomedical study, some works have been reported on small molecule or ligand‐functionalized AIEgens, which show light‐up for bioimaging or responding to some biological small molecules, such as ions, peroxynitrite, glutathione, and cysteine . While the emergence of biomacromolecule‐functionalized AIEgens has generated great interests and new opportunities for biomedical researchers to develop biological applications, such as detection, bioimaging, disease diagnosis, drug screening, cancer treatment, and so forth .…”

Section: Introductionmentioning

confidence: 99%

“…Owing to the AIE effect, an increasing number of functionalized AIEgens have emerged for biomedical study, of which tetraphenylethene (TPE), tetraphenylsilole (TPS), and their derivatives are the most common. [18,19] In biomedical study, some works have been reported on small molecule or ligand-functionalized AIEgens, which show light-up for bioimaging or responding to some biological small molecules, such as ions, [20][21][22] peroxynitrite, [23] glutathione, [24] and cysteine. [25] While the emergence of biomacromoleculefunctionalized AIEgens has generated great interests and new opportunities for biomedical researchers to develop biological applications, such as detection, bioimaging, disease diagnosis,…”

mentioning

confidence: 99%

Biomacromolecule‐Functionalized AIEgens for Advanced Biomedical Studies

Duan

et al. 2019

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The advances in bioinformatics and biomedicine have promoted the development of biomedical imaging and theranostic systems to respectively extend the endogenous biomarker imaging with high contrast and enhance the therapeutic effect with high efficiency. The emergence of biomacromolecule‐functionalized aggregation‐induced emitters (AIEgens), utilizing AIEgens, and biomacromolecules (nucleic acids, peptides, glycans, and lipids), displays specific targeting ability to cancer cell, improved biocompatibility, reduced toxicity, enhanced therapeutic effect, and so forth. This review summarizes the rational design of biomacromolecule‐functionalized AIEgens and their biomedical applications in recent ten years, including high‐resolution optical imaging of cell, tissue, and small animal model with low background; the biomarker detection for early diagnosis and prognosis; the delivery and monitoring of prodrugs; image‐guide photodynamic therapy and its combination with chemotherapy. Through illustrating their functional mechanisms and application, it is hoped that this review would open up a completely new train of research thought for attracted researchers in various fields.

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A turn-on fluorescent probe for cyanide based on aggregation of terthienyl and its application for bioimaging

Cited by 34 publications

References 25 publications

Fluorescence Dyes for Determination of Cyanide

Fluorescence Dyes for Determination of Cyanide

A novel fluorometric turn-on assay for lipase activity based on an aggregation-induced emission (AIE) luminogen

Biomacromolecule‐Functionalized AIEgens for Advanced Biomedical Studies

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