A tunable self-healing ionic hydrogel with microscopic homogeneous conductivity as a cardiac patch for myocardial infarction repair

Song, Xiaoping; Wang, Xiaorui; Zhang, Jie; Shen, Si; Yin, Wenming; Ye, Genlan; Wang, Leyu; Hou, Honghao; Qiu, Xiaozhong

doi:10.1016/j.biomaterials.2021.120811

Cited by 97 publications

(95 citation statements)

References 49 publications

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“…For the H (non‐conductive) and HrhGP0.5 (conductive elastic) ECPs, CMs were directly seeded onto H and HrhGP0.5 (7.5 × 10 5 cells cm −2 ) and cultured for predetermined periods of time. After 3 and 7 days, the samples were subjected to immunofluorescence staining as described previously [ 46 ] using mouse anti‐α‐actinin (1:200), rabbit anti‐CX‐43 (1:200), and rabbit anti‐vWF (1:200) primary antibodies and Alexa Fluor 488 donkey anti‐mouse IgG (H&L) (1:500) and Alexa Fluor 568 donkey anti‐rabbit IgG (H&L) (1:500) secondary antibodies. All samples were observed using an inverted confocal laser scanning microscope.…”

Section: Methodsmentioning

confidence: 99%

A Vascularized Conductive Elastic Patch for the Repair of Infarcted Myocardium through Functional Vascular Anastomoses and Electrical Integration

Xiong

Wang

Guan

et al. 2022

Adv Funct Materials

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Conductive cardiac patches have been proven to promote angiogenesis in infarcted myocardium; however, their conductive integrity, elasticity, and vascularization potential have not yet been optimized. The prevascularization of conductive elastic cardiac patches could be an effective strategy for building a substantial connection between the patch and the infarcted heart. Here, a coronary artery casting is introduced into a holey graphene oxide/polypyrrole‐incorporated polyhydroxyethyl methacrylate prefabricated gel to form a vascularized conductive elastic patch. The engineered patches are able to rebuild functional vascular anastomoses and provide strong electrical integration with infarcted hearts, resulting in effective myocardial infarction repair in vivo. RNA sequencing analyses further reveal that the conductive elastic patches under dynamic culture conditions upregulated cardiac muscle contraction‐ and ATP biosynthesis‐related mRNA expression in vitro. Together, this study demonstrates that the fabricated patches have versatile conductivity, elasticity, and vascularization properties, and could therefore be a promising candidate for heart repair.

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Section: Methodsmentioning

confidence: 99%

A Vascularized Conductive Elastic Patch for the Repair of Infarcted Myocardium through Functional Vascular Anastomoses and Electrical Integration

Xiong

Wang

Guan

et al. 2022

Adv Funct Materials

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“…Due to regular movement of the heart and associated parts, Figure 3: Schematic illustration about the tunable self-healing POG1 hydrogel fabrication and its application in myocardial infarction repair. Reproduced with permission from reference [223]. Journal of Nanomaterials extensive wear and tear are observed; these polymer patches and scaffolds have lower life.…”

Section: Future Perspectivementioning

confidence: 99%

“…Journal of Nanomaterials extensive wear and tear are observed; these polymer patches and scaffolds have lower life. To solve this problem, Song et al prepared self-healing ionic hydrogel made of polyacrylic acid and oxidized alginate (OA)/gelatin (POG) (as shown in Figure 3) [223]. The hydrogel showed super stretchability (>500% strain) and compressive strength (>85% strain).…”

Section: Future Perspectivementioning

confidence: 99%

Nanomaterials: A Promising Therapeutic Approach for Cardiovascular Diseases

Chopra

Bibi

Mishra

et al. 2022

Journal of Nanomaterials

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Cardiovascular diseases (CVDs) are a primary cause of death globally. A few classic and hybrid treatments exist to treat CVDs. However, they lack in both safety and effectiveness. Thus, innovative nanomaterials for disease diagnosis and treatment are urgently required. The tiny size of nanomaterials allows them to reach more areas of the heart and arteries, making them ideal for CVDs. Atherosclerosis causes arterial stenosis and reduced blood flow. The most common treatment is medication and surgery to stabilize the disease. Nanotechnologies are crucial in treating vascular disease. Nanomaterials may be able to deliver medications to lesion sites after being infused into the circulation. Newer point-of-care devices have also been considered together with nanomaterials. For example, this study will look at the use of nanomaterials in imaging, diagnosing, and treating CVDs.

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“…Conductive scaffold materials have a positive effect on the behavior of myocardial cells. Song, XP et al [ 88 ] built PAA nanochannels inside porous ionic conductive hydrogel POG1 hydrogel, giving the hydrogel micro-heterogeneous electrical conductivity to make the cardiomyocytes (CM) inoculated in macroporous ionic conductive hydrogel (POG1) hydrogel show more oriented sarcomere ( Figure 6 ). In addition, POG1 hydrogel has suitable scalability (>500% strain) and compression (>85% strain), and its modulus is similar to that of the mammalian heart (30–500 kPa, Young’s modulus).…”

Section: Application Of Self-healing Hydrogels In Tissue Engineeringmentioning

confidence: 99%

“… Schematic illustration about the fabrication of the tunable self-healing POG1 hydrogel and its application in myocardial infarction repair. Adapted with permission [ 88 ]. Reproduced with permission from Song, X, Biomaterials; published by Elsevier, 2021.…”

Section: Figurementioning

confidence: 99%

Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering

Liang

Yuan

et al. 2022

Polymers

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Self-healing hydrogels and traditional hydrogels both have three-dimensional polymeric networks that are capable of absorbing and retaining a large amount of water. Self-healing hydrogels can heal and restore damage automatically, and they can avoid premature failure of hydrogels caused by mechanical damage after implantation. The formation mechanism of self-healing hydrogels and the factors that hydrogels can load are various. Researchers can design hydrogels to meet the needs of different tissues through the diversity of hydrogels Therefore, it is necessary to summarize different self-healing mechanisms and different factors to achieve different functions. Here, we briefly reviewed the hydrogels designed by researchers in recent years according to the self-healing mechanism of water coagulation. Then, the factors for different functions of self-healing hydrogels in different tissues were statistically analyzed. We hope our work can provide effective support for researchers in the design process of self-healing hydrogel.

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A tunable self-healing ionic hydrogel with microscopic homogeneous conductivity as a cardiac patch for myocardial infarction repair

Cited by 97 publications

References 49 publications

A Vascularized Conductive Elastic Patch for the Repair of Infarcted Myocardium through Functional Vascular Anastomoses and Electrical Integration

A Vascularized Conductive Elastic Patch for the Repair of Infarcted Myocardium through Functional Vascular Anastomoses and Electrical Integration

Nanomaterials: A Promising Therapeutic Approach for Cardiovascular Diseases

Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering

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