A Tumor Microenvironments‐Adapted Polypeptide Hydrogel/Nanogel Composite Boosts Antitumor Molecularly Targeted Inhibition and Immunoactivation

Li, Zhongmin; Xu, Weiguo; Yang, Jia-Zhen; Wang, Juan; Wang, Jialiang; Zhu, Gangjie; Li, Di; Ding, Jianxun; Sun, Tianmeng

doi:10.1002/adma.202200449

Cited by 79 publications

(70 citation statements)

References 39 publications

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“…226 Recently, Li et al developed a composite material consisting of thermosensitive hydrogel and ROS-responsive nanogels to enhance molecularly targeted therapy and activate the immune system against tumours through precise drug release. 227 First, the nanogels are composed of polyamine acid, ROS-responsive thioketal crosslinker, and TGF-b inhibitors (LY3200882, LY) through self-assembly. Then the nanogels and regorafenib (REG) are further co-encapsulated into hydrogels.…”

Section: Nanogels For the Delivery Of Cytokinesmentioning

confidence: 99%

Bioengineered nanogels for cancer immunotherapy

Liu

et al. 2022

Chem. Soc. Rev.

100

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Section: Nanogels For the Delivery Of Cytokinesmentioning

confidence: 99%

Bioengineered nanogels for cancer immunotherapy

Liu

et al. 2022

Chem. Soc. Rev.

100

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“…However, uncertainties in drug loading ratio, release order, and spatiotemporal distribution hinders their synergistic therapeutic effects and clinical applications. Based on this, Li et al [152] developed a tumor microenvironment-adaptive composite consisting of thermosensitive hydrogels and reactive oxygen species (ROS)-responsive nanogels. It can be used for precision drug delivery to enhance molecularly targeted therapy and amplify immune activation.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Biocompatible Conductive Hydrogels: Applications in the Field of Biomedicine

Yang

Lin

Yang

et al. 2022

IJMS

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The impact of COVID-19 has rendered medical technology an important factor to maintain social stability and economic increase, where biomedicine has experienced rapid development and played a crucial part in fighting off the pandemic. Conductive hydrogels (CHs) are three-dimensional (3D) structured gels with excellent electrical conductivity and biocompatibility, which are very suitable for biomedical applications. CHs can mimic innate tissue’s physical, chemical, and biological properties, which allows them to provide environmental conditions and structural stability for cell growth and serve as efficient delivery substrates for bioactive molecules. The customizability of CHs also allows additional functionality to be designed for different requirements in biomedical applications. This review introduces the basic functional characteristics and materials for preparing CHs and elaborates on their synthetic techniques. The development and applications of CHs in the field of biomedicine are highlighted, including regenerative medicine, artificial organs, biosensors, drug delivery systems, and some other application scenarios. Finally, this review discusses the future applications of CHs in the field of biomedicine. In summary, the current design and development of CHs extend their prospects for functioning as an intelligent and complex system in diverse biomedical applications.

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“…Most importantly, we discussed the potential clinical applications of MSCs and iPS cell membrane-camouflaged targeted delivery systems for anti-tumor therapies, such as chemotherapy, photodynamic therapy, magnetic hyperthermia therapy, imaging, CRISPR-Cas9 gene therapy, and synergistic therapy ( Table 1 ). In the future, the applications of this delivery system should be further investigated in other anti-tumor therapies, such as tumor blockade therapy [ 80 ] and anti-tumor immune therapy [ 81 ]. To sum up, stem cell membrane-coated NPs hold the tremendous prospect for biomedical applications in tumor therapy.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%