A trustworthy CpG nanoplatform for highly safe and efficient cancer photothermal combined immunotherapy

Jiang, Ming; Zhang, Jinjia; Shi, Yiran; Yang, Wangheng; Li, Jingchao; Sun, Dong; Xiang, Sijin; Chen, Xiaolan; Chen, Lanfen; Zheng, Nanfeng

doi:10.1039/c9nr09402d

Cited by 53 publications

(47 citation statements)

References 47 publications

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“…[65] Zheng et al used palladium (Pd) nanosheets as carriers of CpG, which achieved a prominent therapeutic effect through synergistic PTT and immunotherapy. [66] Wei et al fabricated a self-assembled nanoplatform by coloading immunoadjuvants of CpG, resiquimoid (R848), and a photothermal agent, indocyanine green (ICG), into the thermosensitive PLEL hydrogel, which elicited photothermal enhanced immune responses against postsurgical recurrence and metastasis of breast cancer. [67] Some other immunoadjuvants, including R837, aluminum hydroxide, ovalbumin (OVA), and glycated chitosan, have also been combined with HTT to achieve a synergistic enhanced therapeutic effect.…”

Section: Htt-synergized Immunoadjuvant Therapymentioning

confidence: 99%

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

et al. 2020

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Figure 3. a) Schematic illustration of the PTT-assisted immunotherapy. b) PD-L1 expression on 4T1 tumor cells after different treatments. c) Flow cytometric examination of the intratumor infiltration of CD4 + and CD8 + T cells. d,e) The primary and distal tumor growth curves of 4T1 tumor-bearing mice. f) Quantification of pulmonary metastasis nodules in different groups of 4T1 tumor-bearing mice. g) The tumor growth curves of B16F10-bearing mice model (*p < 0.05, **p < 0.01, ***p < 0.001). Reproduced with permission. [52] Copyright 2019, Nature Research.

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Section: Htt-synergized Immunoadjuvant Therapymentioning

confidence: 99%

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

et al. 2020

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“…Enhanced anti-cancer effects have been successfully obtained by the combination of photothermal agents and immune checkpoint blockades 94 and immunoadjuvants 95 - 97 . Recently, Pd NSs were reported as carriers of immunoadjuvant CpG oligodeoxynucleotides by our group 98 . CpG recognized by Toll-like receptor 9 (TLR9) in the endosomes of antigen-presenting cells (APCs), exhibits potent immunostimulatory activities and has become a promising immunotherapeutic agent (Figure 9 A).…”

Section: Cancer Therapy Using Pd-based Nanomaterialsmentioning

confidence: 99%

Palladium-based nanomaterials for cancer imaging and therapy

Liu

Chen

et al. 2020

Theranostics

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In recent decade, palladium-based (Pd-based) nanomaterials have shown significant potential for biomedical applications because of their unique optical properties, excellent biocompatibility and high stability in physiological environment. Compared with other intensively studied noble nanomaterials, such as gold (Au) and silver (Ag) nanomaterials, research on Pd-based nanomaterials started late, but the distinctive features, such as high photothermal conversion efficiency and high photothermal stability, have made them getting great attention in the field of nanomedicine. The goal of this review is to provide a comprehensive and critical perspective on the recent progress of Pd-based nanomaterials as imaging contrast agents and therapeutic agents. The imaging section focuses on applications in photoacoustic (PA) imaging, single-photon emission computed tomography (SPECT) imaging, computed tomography (CT) imaging and magnetic resonance (MR) imaging. For treatment of cancer, single photothermal therapy (PTT) and PTT combined with other therapeutic modalities will be discussed. Finally, the safety concerns, forthcoming challenges and perspective of Pd-based nanomaterials on biomedical applications will be presented.

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“…Lately, Zheng's group fabricated a novel Pd-CpG nanoplatform for PTT/IT with good synergy. [142] They obtained Pd-CpG nanocomposites with different Pd sizes (Pd(5):5 nm and Pd(30):30 nm) by exploiting Pd nanosheets as PTAs to load HS-CpG ODNs (CPG (PS)), which were conjugated with thiol groups. Moreover, in the group of mice treated with Pd (5)-CpG (PS)+NIR, the tumor growth was largely suppressed, in fact, 80% of the mice were entirely cured after 10 days when compared to the other groups.…”

Section: Ptt and Immunotherapymentioning

confidence: 99%

“…[214] To overcome this problem, researchers have , 5 min) after 24 h. Reproduced with permission. [142] Copyright 2020, Royal Society of Chemistry. developed many gene vectors to improve delivery of the nucleic acids.…”

Section: Other Synergistic Therapiesmentioning

confidence: 99%

Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

Wen

Tamarov

Happonen

et al. 2020

Advanced Therapeutics

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Inorganic photothermal agents (PTAs) have attracted considerable attention in cancer theranostics due to their unique features such as high photothermal conversion efficacy, excellent photothermal stability, and straightforward functionalization. The first part of this Review summarizes progress in methods for synthesizing PTAs, then considers in vitro photothermal evaluations, as well as in vivo photothermal-based applications that attempt to overcome different barriers in cancer theranostics. Next, a clinical trial with an inorganic PTA is described. The final part of the Review examines the challenges and possibilities for successful transfer of inorganic PTAs from the laboratory to the clinic.

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A trustworthy CpG nanoplatform for highly safe and efficient cancer photothermal combined immunotherapy

Abstract: Ultra-small palladium nanosheets are employed as the safe carriers of immunoadjuvant CpG for highly efficient cancer photothermal combined immunotherapy.

Cited by 53 publications

References 47 publications

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Palladium-based nanomaterials for cancer imaging and therapy

Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

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