A triterpene glycoside from Scrophularia koelzii

Context: Scrophularia genus (Scrophulariaceae) includes about 350 species commonly known as figwort. Many species of this genus grow wild in nature and have not been cultivated yet. However, some species are in danger of extinction. Objective: This paper reviews the chemical compounds, biological activities and the ethnopharmacology of some Scrophularia species. Materials and methods: All information was obtained through reported data on bibliographic database such as Scopus, United States National Agricultural Library, Biological Abstracts, EMBASE, PubMed, MedlinePlus, PubChem and Springer Link (1934–2017). The information in different Pharmacopoeias on this genus was also gathered from 1957 to 2007. Results: The structures of 204 compounds and their biological activity were presented in the manuscript: glycoside esters, iridoid glycosides and triterpenoids are the most common compounds in this genus. Among them, scropolioside like iridoids have shown potential for anti-inflammatory, hepatoprotective and wound healing activity. Among the less frequently isolated compounds, resin glycosides such as crypthophilic acids have shown potent antiprotozoal and antimicrobial activities. Conclusion: The Scrophularia genus seems to be a rich source of iridoids and terpenoids, but isolation and identification of its alkaloids have been a neglected area of scientific study. The diverse chemical compounds and biological activities of this genus will motivate further investigation on Scrophularia genus as a source of new therapeutic medications.

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“… 1993b ; Bhandari et al. 1996 , 1997 ). Verbascosaponin A ( 188 ) as an oleanane-type triterpenoid was isolated from S. auriculata ssp.…”

Section: Resultsmentioning

confidence: 99%

The genus Scrophularia: a source of iridoids and terpenoids with a diverse biological activity

Pasdaran

Hamedi

2017

Pharmaceutical Biology

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“…The new compound was visualized by spraying with 1% (w/v) Ce(SO 4 ) 2 in 10% (v/v) aqueous H 2 SO 4 , followed by heating at 120 °C, and it displayed purplish black spots on a thin-layer chromatography (TLC) plate, suggesting that it possessed the basic triterpenoid skeleton [ 15 ]. The IR spectrum showed absorption bands at 3386, 1717, 1655, 1077, and 1047 cm −1 due to hydroxyl; α , β -unsaturated ester; carboxy; and ether functions.…”

Section: Resultsmentioning

confidence: 99%

A New Saponin from Tea Seed Pomace (Camellia oleifera Abel) and Its Protective Effect on PC12 Cells

et al. 2012

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A new triterpenoid saponin, oleiferasaponin A1, was isolated from tea seed pomace (Camellia oleifera Abel). The structure of oleiferasaponin A1 was elucidated on the basis of chemical and physicochemical evidence and was found to be 22-O-cis-2-hexenoyl-A1-barrigenol 3-O-[β-D-galactopyranosyl(1→2)] [β-D-glucopyranosyl(1→2)-α-L-arabinopyranosyl(1→3)]-β-D-glucopyranosiduronic acid. PC12 cells injured with H2O2 were used as the model to test the protective effects of oleiferasaponin A1. The results indicated that oleiferasaponin A1 can potentially prevent the H2O2-induced cell death of PC12 cells.

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“…The hepatoprotective activity and immunostimulant activity of these four iridoids seem to be complimentary. Some of the catalpol glycosides are reported to show immunostimulant activity (Pandey & Das, 1988) and these compounds are present in a number of species from the Scrophularia genus (Bhandari et al, 1992(Bhandari et al, , 1997Calis et al, 1993;De Santos et al, 1998;Giner et al, 1998;Zhang et al, 1992).…”

Section: Immunomodulatingmentioning

confidence: 99%