A trial to stimulate insulin like growth factor-I levels to improve superovulatory response in dairy cows

Herrler, Andreas; Farries, E.; Niemann, Heiner

doi:10.1016/0093-691x(90)90672-g

Cited by 7 publications

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“…4 and 5). To support this, a preliminary study in which dairy cows were given an s.c. depot of 640 mg BST 6 days before superovulation was induced with 2500 IU PMSG [14] demonstrated that the number of embryos collected was increased.…”

Section: Discussionmentioning

confidence: 97%

“…Therefore, if the small follicles induced by BST treatment are functionally healthy, the increase in numbers of small antral follicles induced by BST treatment may enhance the superovulatory response. Co-treatment with growth hormone (GH) has been shown to improve the response of ovulation induction in women undergoing in vitro fertilzation (although not consistently) [10][11][12] and to increase the superovulatory response in cattle to a limited extent [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Recombinant Bovine Somatotropin on the Superovulatory Response to Pregnant Mare Serum Gonadotropin in Heifers

Gong

Bramley

Wilmut

et al. 1993

Biology of Reproduction

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Treatment of mature heifers with recombinant bovine somatotropin (BST) increases the number of ovarian follicles of 2-5 mm in diameter. This study was carried out to investigate whether the increase in the number of small follicles induced by BST treatment can enhance the superovulatory response. In the first experiment, 24 heifers were assigned, in a randomized block design, to four treatment groups: 1) control; 2) BST; 3) pregnant mare serum gonadotropin (PMSG); 4) BST+PMSG. On Day 7 of the estrous cycle, animals in groups 2 and 4 received injections of 320 mg BST (in a sustained release formulation), while heifers in groups 1 and 3 received 10 ml saline. Five days later heifers in groups 3 and 4 were treated with a single dose of 2000 IU PMSG to induce superovulation. Embryos were recovered nonsurgically on Days 6-8 of the following cycle, and all heifers underwent laparoscopy on Day 9 to assess ovulation rate. In a second experiment, 24 heifers were assigned randomly to four treatment groups: 1) PMSG (1000 IU); 2) BST (320 mg) + PMSG (1000 IU); 3) PMSG (2000 IU); 4) BST (320 mg) + PMSG (2000 IU), and then treated as for experiment I. In both experiments, all heifers were scanned daily using real-time ultrasound from the day before BST injection until the day of ovulation to monitor dynamics of ovarian follicular growth and development, and blood samples were collected daily throughout the experimental period for measurement of peripheral progesterone, estradiol-17 beta, growth hormone (GH), and insulin-like growth factor-I (IGF-I).(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 97%