Effects of insulin-like growth factor-I on in-vitro production of bovine embryos

Herrler, Andreas; Lucas‐Hahn, Andrea; Niemann, Heinrich

doi:10.1016/0093-691x(92)90177-s

Cited by 75 publications

(49 citation statements)

References 31 publications

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“…These results are consistent with those of previous reports and studies asserting that IGF-I stimulates maturation in Xenopus oocytes [21], bovine oocyte and fertilization in vitro [22], and supports rabbit blastocyst development [23] and human oocyte and blastocyst development [24]. It is concluded that IGF-I have an important role in the nuclear maturation and cytoplasmic maturation of oocytes and exert its effect through cumulus cells.…”

Section: Discussionsupporting

confidence: 82%

Influence of Insulin-Like Growth Factor-I on Maturation and Fertilization Rate of Immature Oocyte and Embryo Development in NMRI Mouse with TCM199 and α -MEM Medium

Toori

Mosavi

Nikseresht

et al. 2014

JCDR

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Section: Discussionsupporting

confidence: 82%

Influence of Insulin-Like Growth Factor-I on Maturation and Fertilization Rate of Immature Oocyte and Embryo Development in NMRI Mouse with TCM199 and α -MEM Medium

Toori

Mosavi

Nikseresht

et al. 2014

JCDR

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“…There are conflicting data on the effects of IGF-I during culture for oocyte maturation on subsequent embryonic development. In cattle, IGF-I added to maturation medium did not increase the proportion of embryos developing to the morula and blastocyst stages [4]. This may have been due to the presence of hormones and serum in maturation medium.…”

Section: Discussionmentioning

confidence: 95%

Possible Involvement of Insulin-like Growth Factor-I in Mediating the Stimulatory Effect of Recombinant Bovine Growth Hormone on Maturation of Bovine Oocytes In Vitro.

Iga

Niwa

Bartke

1998

Journal of Reproduction and Development

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“…However, results from bovine studies are not as clear. Although some studies indicate that IGF-I has little influence on developmental frequencies (Larson et al, 1992), other studies report dose-responsive influences on development of bovine zygotes to the blastocyst stage (Herrler et al, 1993;Palma et al, 1997).…”

mentioning

confidence: 99%

Expression of the insulin-like growth factor (IGF) system in the bovine oviduct at oestrus and during early pregnancy

Pushpakumara¹,

Robinson²,

Demmers³

et al. 2002

Reproduction

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Early mammalian embryo development in vitro can be enhanced by co-culture with oviductal cells and by the addition of insulin-like growth factors (IGFs). This study examined the expression patterns of the oviductal IGF system in cattle in relation to the number of days after oestrus and the presence or absence of embryos. Oviducts were collected from: (i) 66 nulliparous heifers on day 3, day 6 or day 16 after insemination and from (ii) ten non-pregnant, lactating cows on day 0 or day 1 of the oestrous cycle. Oviducts were coiled, frozen whole and sectioned for in situ hybridization. Expression patterns of mRNAs encoding IGF-I, IGF-II, type 1 IGF receptor (IGF-1R), and the IFG binding proteins (IGFBP)-1, -3 and -5 were determined from autoradiographs. Separate measurements were made for the mucosa and muscle layers of the infundibulum, ampulla and isthmus. None of the parameters measured differed between heifers with or without the presence of an embryo. mRNAs encoding IGF-I and IGF-1R were present in the mucosa and muscle of all three oviductal regions, and the highest value of IGF-I mRNA was measured in heifers on day 3. IGF-II mRNA was expressed predominantly in the muscle wall. IGFBP-1 mRNA was not detectable, whereas mRNAs encoding IGFBP-3 and -5 were expressed in both the muscle and mucosa. IGFBP-3 expression was higher in cows on day 0 and day 1 of the oestrous cycle than in heifers on day 3, day 6 and day 16 after insemination. A peak of IGFBP-5 expression was reached on day 6. Locally or systemically produced IGFs, regulated by IGFBPs, may act directly on the embryo or indirectly via modulation of oviductal secretions and muscular activity to influence the success of early embryo development.

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Effects of insulin-like growth factor-I on in-vitro production of bovine embryos

Cited by 75 publications

References 31 publications

Influence of Insulin-Like Growth Factor-I on Maturation and Fertilization Rate of Immature Oocyte and Embryo Development in NMRI Mouse with TCM199 and α -MEM Medium

Influence of Insulin-Like Growth Factor-I on Maturation and Fertilization Rate of Immature Oocyte and Embryo Development in NMRI Mouse with TCM199 and α -MEM Medium

Possible Involvement of Insulin-like Growth Factor-I in Mediating the Stimulatory Effect of Recombinant Bovine Growth Hormone on Maturation of Bovine Oocytes In Vitro.

Expression of the insulin-like growth factor (IGF) system in the bovine oviduct at oestrus and during early pregnancy

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