A Trial Establishment of Reference Interval of Serum Lipids Levels for the Elderly and Effects of Aging on Total Cholesterol, HDL-C, TG and LDL-C Levels.

幸夫, 江角; 久美子, 安達; こずえ, 高橋; 靖彦, 深田; 昭彦, 陶山

doi:10.2185/jjrm.49.12

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“…The exclusion criteria included major psychiatric or neurological disorders; heart failure; stroke; and/or history of alcohol or drug abuse. All participants were right-handed and had no history of diabetes (hemoglobin [Hb] A1c < 6.5%), hypertension (systolic blood pressure [SBP]/diastolic blood pressure [DBP] < 140/90 mmHg), hyperlipidemia (total cholesterol < 280 mg/dL), low-density lipoprotein [LDL] < 190 mg/dL, high-density lipoprotein [HDL] > 40 mg/dL, or triglyceride < 150 mg/dL]) (Esumi et al, 2000), or obesity (body mass index [BMI] < 25 kg/m 2 ). Furthermore, we used the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality, de ned as an individual's subjective satisfaction with various aspects of sleep.…”

Section: Study Participantsmentioning

confidence: 99%

Glymphatic dysfunction and choroid plexus volume increase in older adults with poor sleep quality

Kikuta

2024

Preprint

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Objective This study aimed to explore alterations in diffusion tensor image analysis along the perivascular space (DTI-ALPS) method and choroid plexus volume (CPV), which could be biomarkers of the glymphatic system in older adults with poor sleep quality (PSQ). Methods Fifty-two Japanese older adults with Pittsburgh Sleep Quality Index (PSQI) scores > 5 (22 men and 30 women; mean age ± SD = 73.10 ± 5.67 years) and 52 healthy controls (HCs; PSQI score ≤ 5) were included. Diffusion-weighted imaging (DWI) and 3D T1-weighted images were obtained using 3T magnetic resonance imaging. The ALPS index was calculated using preprocessed diffusion-weighted imaging (DWI), and the CPV was calculated using FreeSurfer 6.0. The mean ALPS index was subsequently compared between the PSQ group and HCs by using a general linear model (GLM) adjusted for covariates, including age, sex, years of education, intracranial volume, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, and white matter lesion volume (WMLV). The CPV was also compared between the two groups by using the GLM, adjusting for the same covariates mentioned above. Next, we conducted a partial correlation analysis between the ALPS index and the CPV, Montreal Cognitive Assessment (MoCA), and PSQI scores, adjusting for all the abovementioned covariates. Results Compared with HCs, patients in the PSQ group had a significantly lower mean ALPS (p = 0.04, Cohen’s d = − 0.28) and a greater CPV (p = 0.11, Cohen’s d = 0.24). In the PSQ group, the mean ALPS score was significantly negatively correlated with the CPV (r = − 0.35, false discovery rate [FDR]-corrected p = 0.03) but was significantly positively correlated with the MoCA score (r = 0.35, FDR-corrected p = 0.03). Conclusion Older adults with PSQ exhibited a decrease in the glymphatic system and an increase in CPV.

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Section: Study Participantsmentioning

confidence: 99%

Glymphatic dysfunction and choroid plexus volume increase in older adults with poor sleep quality

Kikuta

2024

Preprint

View full text Add to dashboard Cite

show abstract

A Trial Establishment of Reference Interval of Serum Lipids Levels for the Elderly and Effects of Aging on Total Cholesterol, HDL-C, TG and LDL-C Levels.

Cited by 1 publication

References 1 publication

Glymphatic dysfunction and choroid plexus volume increase in older adults with poor sleep quality

Glymphatic dysfunction and choroid plexus volume increase in older adults with poor sleep quality

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