A trend analysis of breast cancer incidence in Sri Lanka, 2005-2019a

Weerakoon, Saddharma; Suranaga, Malvige Amila; Vidanapathirana, Janaki; Perera, Upuli

doi:10.4038/jccpsl.v27i5.8438

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The age standardized breast cancer rates of Sri Lanka women, although lower than in developed countries, has notably increased over time, form 18.4 per 100,000 population in 2005 to 33.5 in 2019 (10). Sri Lanka does not offer population screening mammography for women at average risk of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Breast cancer surveillance in BRCA positive Sri Lankan women: health equity for a high-risk group at a limited resource setting

Liyanage,

Sirisena,

Deshapriya

et al. 2023

Preprint

View full text Add to dashboard Cite

Background BRCA1 and BRCA2 pathogenic variants account for 90% of hereditary breast malignancies, incurring a lifetime breast cancer risk of 85% and 40-45% respectively, in affected individuals. Well-resourced health care settings offer genetic counselling and genetic screening for susceptible individuals, followed by intense breast cancer surveillance programmes for those identified at high risk of breast cancer. Such high standards of care are not available in countries with limited resources. This study assessed breast screening behaviors among a cohort of BRCApositive Sri Lankan women. Methods A retrospective case review of all patients diagnosed with pathogenic variants in BRCA1 and BRCA2 genes from 2015 to 2022 at the Human Genetics Unit, Faculty of Medicine, University of Colombo was carried out, followed by a telephone interview of the respondents. Patients who were not contactable, deceased, undergone bilateral mastectomy and males were excluded from the interview component of the study. Results Only 25 patients were diagnosed during the study period:14/25 women responded (6/25 deceased, 3/25 non-contactable; 2/25 excluded). 71.4% (10/14) had performed breast self-examination during the preceding month; 35.7% (5/14) had a clinical breast examination (CBE), and 50% (7/14) had undergone a screening/diagnostic mammogram during the previous year. 28.5% (4/14) underwent both mammography and CBE; 21.45% (3/14) mammogram only, 7.1% (1/14) had CBE only. 42.8%(6/14) had not under gone any surveillance(mammography or CBE). None had dual screening with mammogram and MRI. 85.71% (12/14) women expressed willingness to participate in a regular screening programme if made available. Conclusion Fifty percent of BRCA1/2 positive women in our study had not undergone annual mammographic screening, and none had undergone annual dual screening with mammography and MRI indicating inadequate breast cancer surveillance in this high-risk group.

show abstract

Section: Introductionmentioning

confidence: 99%

Breast cancer surveillance in BRCA positive Sri Lankan women: health equity for a high-risk group at a limited resource setting

Liyanage,

Sirisena,

Deshapriya

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Sri Lanka's age-standardized breast cancer rates have risen from 18.4 per 100,000 in 2005 to 33.5 in 2019 [ 11 ]. Free healthcare is offered in the state sector, and the national cancer control programme (NCCP) of Sri Lanka advocates early detection of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Breast cancer surveillance in BRCA positive Sri Lankan women: health equity for a high-risk group at a limited resource setting

Liyanage,

Sirisena,

Deshapriya

et al. 2023

BMC Women's Health

View full text Add to dashboard Cite

Background BRCA1 and BRCA2 pathogenic variants account for 90% of hereditary breast malignancies, incurring a lifetime breast cancer risk of 85% and 40–45% respectively, in affected individuals. Well-resourced health care settings offer genetic counselling and genetic screening for susceptible individuals, followed by intense breast cancer surveillance programmes for those identified at high risk of breast cancer. Such high standards of care are not available in countries with limited resources. This study assessed breast cancer surveillance behaviors among a cohort of BRCA positive Sri Lankan women. Methods A retrospective case review of all patients diagnosed with pathogenic variants in BRCA1 and BRCA2 genes from 2015 to 2022 at the Human Genetics Unit, Faculty of Medicine, University of Colombo was carried out followed by telephone interviews of the respondents. Patients who were not contactable, deceased, undergone bilateral mastectomy and males were excluded from the interview component of the study. Standard descriptive statistics were used to analyze the data using SPSS statistics version 25. Results Only 25 patients were diagnosed during the study period:14/25 women responded (6/25 deceased, 3/25 non-contactable; 2/25 excluded). 71.4% (10/14) had performed breast self-examination during the preceding month; 35.7% (5/14) had a clinical breast examination (CBE), and 50% (7/14) had undergone a screening/diagnostic mammogram during the last one year. 28.5% (4/14) had undergone both mammography and CBE; 21.45% (3/14) mammogram only, 7.1% (1/14) had CBE only. 42.8%(6/14) had not undergone any surveillance(mammography, CBE or MRI). None had dual screening with mammogram and MRI. 85.71% (12/14) women expressed willingness to participate in a regular screening programme if made available. Conclusion Fifty percent of BRCA1/2 positive women in our study had not undergone annual imaging-based surveillance by mammography or MRI, and none had undergone annual dual screening with mammography and MRI, indicating inadequate breast cancer surveillance in this high-risk group.

show abstract

A trend analysis of breast cancer incidence in Sri Lanka, 2005-2019a

Cited by 2 publications

References 0 publications

Breast cancer surveillance in BRCA positive Sri Lankan women: health equity for a high-risk group at a limited resource setting

Breast cancer surveillance in BRCA positive Sri Lankan women: health equity for a high-risk group at a limited resource setting

Breast cancer surveillance in BRCA positive Sri Lankan women: health equity for a high-risk group at a limited resource setting

Contact Info

Product

Resources

About