A transistor-based biosensor for the extraction of physical properties from biomolecules

Abstract

An analytical technique is proposed that uses an asymmetric double-gate field-effect transistor (FET) structure to characterize the electrical properties of biomolecules, including their permittivity and charge density. Using a simple measurement with the proposed FET structure, we are able to extract the physical properties (i.e., permittivity and charge density) of biomolecules. A reliable analytical tool for the characterization of biomolecules can be provided by the proposed FET structure without a complex measurement system. It is expected that the proposed method will be expanded into a universal analysis technique for the electrical evaluation of biomolecules in applications beyond biosensing. V

Sensing glucose concentrations at GHz frequencies with a fully embedded Biomicro-electromechanical system (BioMEMS)

“…Applications appear promising in the field of intelligent biosensors, where it enables the monolithic integration of sensing devices with intelligent functions like detection, signal analysis, electrical stimulation, data transmission, etc., in a single microchip. [1][2][3] In particular, low-cost implants for monitoring metabolites in the human body are strongly requested by medical diagnostics, with D-glucose representing the most important one. According to WHO, about 346 Â 10 6 patients worldwide suffer from diabetes, 4 i.e., are subjected to persistent deviations from glucose concentrations c g that normally should lie between 3.6 and 6.1 mM.…”

Investigation of dielectric modulated (DM) double gate (DG) junctionless MOSFETs for application as a biosensors

“…The presence of the neutral biomolecules in the nanogap cavity is simulated by introducing material having dielectric constant (K > 1) corresponding to biomolecules (for e.g. streptavidin = 2.1 [33], protein = 2.50, biotin = 2.63 [34], and APTES = 3.57 [35]) [36] in the nanogap cavities (assuming that the cavities are completely filled with biomolecules). In order to simulate the effect of charged biomolecules, negative or positive interface fixed charge (N f = ±4 Â 10 16 m À2 ) (for e.g.…”

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