A transcranial doppler study in interictal migraine and tension‐type headache

Arjona, Antonio; Torres, Luis Ángel Pérula de; Serrano-Castro, Pedro J.; Guardado-Santervás, P; Olivares, J.; Rubí-Callejón, J

doi:10.1002/jcu.20350

Cited by 19 publications

(27 citation statements)

References 27 publications

(30 reference statements)

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“…It is known that ischemic cerebral infarction preferentially affects the posterior cerebral artery distribution in migraine patients (5). However, the vast majority of known studies have evaluated cerebral endothelial function just in the anterior cerebral circulation (9)(10)(11)(12)(13)(14)(15). Hyperreactivity, hyporeactivity, and no difference in reactivity were observed.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the previous studies that evaluated the reactivity of cerebral arteries in migraine patients were performed by measuring changes in the partial arterial pressure of carbon dioxide (CO 2 ) (9)(10)(11)(12)(13)(14)(15). But only a few have specifically compared endothelial function in both cerebral circulations in migraine patients compared to healthy subjects (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

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Cerebrovascular reactivity to l-arginine in the anterior and posterior cerebral circulation in migraine patients

Perko¹,

Oblak²,

Šabovič

et al. 2011

Acta Neurologica Scandinavica

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OBJECTIVE - Cerebral infarction preferentially affects the posterior cerebral artery distribution in migraine patients. The results obtained from the few known studies that have compared the anterior and posterior cerebral endothelial function are contradictory. To the best of our knowledge, cerebrovascular reactivity to L-arginine (CVR), measured by transcranial Doppler sonography (TCD), has not been previously used to determine the posterior cerebral endothelial function in migraine patients with (MwA) and without aura (MwoA). MATERIALS AND METHODS - Forty migraine patients without comorbidities (20 MwA, 20 MwoA) and 20 healthy subjects were included. By employing strict inclusion criteria, we avoided the possible vascular risk factors. Mean arterial velocity in the middle cerebral artery (MCA) and the posterior cerebral artery (PCA) was measured by TCD before and after infusion of L-arginine, and CVR to L-arginine was then calculated. RESULTS - All migraine patients had lower CVR to L-arginine in PCA (P = 0.002) and similar in MCA (P = 0.29) compared to healthy subjects. This difference was also present in MwA and MwoA compared to healthy subjects (P = 0.003). CONCLUSIONS - Lower CVR to L-arginine in PCA in migraine patients could associate migraine and cerebral infarcts that are more common in the posterior cerebral artery distribution.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cerebrovascular reactivity to l-arginine in the anterior and posterior cerebral circulation in migraine patients

Perko¹,

Oblak²,

Šabovič

et al. 2011

Acta Neurologica Scandinavica

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“…Migraine and episodic tension-type headaches may also relate to vascular changes of CBF (5, 6, 8, 10). Nowak et al (19) found that children with migraines and chronic-type headaches had increased CBFV during visual stimulation, due to increased cerebrovasodilation.…”

Section: Discussionmentioning

confidence: 99%

Increased Pulsatile Cerebral Blood Flow, Cerebral Vasodilation, and Postsyncopal Headache in Adolescents

Ocon

Messer

Medow

et al. 2011

The Journal of Pediatrics

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Objective We hypothesize that following a sudden decrease in cerebral blood flow velocity (CBFV) in adolescents at faint, rapid hyperemic pulsatile CBFV occurs upon the return to the supine position, and is associated with post-syncopal headache. Study design This case-control study involved 16 adolescent subjects with history of fainting and headaches. We induced faint during 70° tilt-table testing and measured mean arterial pressure (MAP), heart rate (HR), end-tidal CO2, and CBFV. Fifteen control subjects were similarly evaluated with a tilt but did not faint, and comparisons with fainters were made at equivalent defined time points. Results Baseline values were similar between groups. Upon fainting, MAP decreased 49% in fainters vs. 6% in controls (P<0.001). HR decreased 15% in fainters and increased 35% in controls (P<0.001). In fainters, cerebrovascular critical closing pressure increased markedly resulting in reduced diastolic (-66%) and mean CBFV (-46%) at faint; systolic CBFV was similar to controls. Pulsatile CBFV (systolic – diastolic CBFV) increased 38% in fainters, driving flow-mediated dilation of cerebral vessels. Returning to supine, fainters’ CBFV exhibited increased systolic and decreased diastolic flows compared with controls (P<0.02). Conclusion Increased pulsatile CBFV during and following faint may cause post-syncopal cerebral vasodilation and headache.

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“…Studying neural adaptation through refractory effects may also be of interest in certain disease states of the brain including epilepsy (8), headache disorders (9), and vascular dementia (10). To be useful in investigating these diseases, fMRI must provide insight into individual patient data (i.e., at the single-subject level).…”

mentioning

confidence: 99%

Quantifying hemodynamic refractory bold effects in normal subjects at the single‐subject level using an inverse logit fitting procedure

Descamps

Vandemaele

Reyngoudt

et al. 2011

Magnetic Resonance Imaging

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Purpose: To evaluate whether hemodynamic refractory effects provoked by repeated visual stimulation can be detected and quantified at the single-subject level using a recently described hemodynamic response function (HRF) fitting algorithm. Materials and Methods:Hemodynamic refractory effects were induced with an easily applicable functional MRI (fMRI) paradigm. A fitting method with inverse logit (IL) functions was applied to quantify net HRFs at the singlesubject level with three interstimulus intervals (ISI; 1, 2, and 6 s). The model yielded amplitude, latencies, and width for each HRF.Results: HRF fitting was possible in 44 of 51 healthy volunteers, with excellent goodness-of-fit (R 2 ¼ 0.9745 6 0.0241). Refractory effects were most pronounced for the 1-s ISI (P < 0.001) and had nearly disappeared for the 6-s ISI.Conclusion: Quantifying refractory effects in individuals was possible in 86.3% of normal subjects using the IL fitting algorithm. This setup may be suitable to explore such effects in individual patients.

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A transcranial doppler study in interictal migraine and tension‐type headache

Abstract: Our findings support the arteriolar vasodilatation theory in migraine without aura.

Cited by 19 publications

References 27 publications

Cerebrovascular reactivity to l-arginine in the anterior and posterior cerebral circulation in migraine patients

Cerebrovascular reactivity to l-arginine in the anterior and posterior cerebral circulation in migraine patients

Increased Pulsatile Cerebral Blood Flow, Cerebral Vasodilation, and Postsyncopal Headache in Adolescents

Quantifying hemodynamic refractory bold effects in normal subjects at the single‐subject level using an inverse logit fitting procedure

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