A Topical Desiccant Agent in Association with Manual Debridement in the Initial Treatment of Peri-Implant Mucositis: A Clinical and Microbiological Pilot Study

Abstract

In patients presenting mucositis, effective sub-gingival debridement is crucial to prevent peri-implantitis. The aim of this randomized study was to assess the three-month (T1) effects of a locally delivered liquid desiccant agent with molecular hygroscopic properties, in association with manual debridement, at sites with peri-implant mucositis. Twenty-three patients presenting at least one implant with no radiographically detectable bone loss, a pocket probing depth (PPD) ≥ 4 mm, and bleeding on probing (BOP), were included. At baseline (T0), patients were randomly assigned to receive the aforementioned desiccant agent before debridement (Test-Group), or a Chlorhexidine 1% disinfectant gel after debridement (Control-Group). Treatments were repeated after seven and 14 days. Peri-implant soft tissue assessment [PPD, BOP, Modified Bleeding Index (mBI), Visible Plaque Index (VPI), and Modified Plaque Index (mPLI)] and microbial sampling were performed at T0 and T1. At T1 the Test-Group presented significantly greater reductions for BOP, mBI, VPI, and mPLI. Concerning the deepest sites of the treated implants, both groups showed statistically significant reductions for BOP and mBI between T0 and T1. Furthermore, the Test-Group exhibited a significant decrease in anaerobic bacteria. Despite these valid outcomes, a complete resolution of the inflammatory conditions was not achieved by any of the groups.

Regenerative Endodontic Therapy using a New Antibacterial Root Canal Cleanser in necrotic immature permanent teeth: Report of two cases treated in a single appointment

“…20,21 It was successfully used for the treatment of chronic periodontitis to enhance the efficacy of traditional therapy (scaling and root planing), and it reduces pathogens of periodontal socket biofilm. 22,23 Consistent results were described in a case report for the treatment of an acute periodontal abscess. 24 The present report describes 2 regenerative endodontic treatment using HYBENX® cleanser as antibiofilm agent in two immature necrotic teeth with periapical radiolucency.…”

Preliminary Phytochemical Analysis of Berberis goudotii Triana & Planch. ex Wedd. (Berberidaceae) with Anticariogenic and Antiperiodontal Activities

“…One of them is a drying agent that allows for easier biofilm removal. It is a safe technique, which diminishes bacterial load, thus reducing inflammation in periodontitis treatment [20][21][22]. Likewise, other studies propose herbal chlorhexidine in post-surgery protocols, as biofilm inhibitors, providing comfort to the patient after surgery [23].…”

Clinical Efficacy of Single Application Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis

“…These acids form a strong bond with water available in the biofilm matrix, which rapidly detaches, destroys, and eradicates the biofilm itself. A preliminary study that utilized this desiccant with ultrasonic mechanical debridement found greater bacterial load reduction and enhanced effectiveness of mechanical debridement [ 77 ].…”