A tool to predict suicidal ideation and behavior in bipolar disorder: The Concise Health Risk Tracking Self-Report

Reilly-Harrington, Noreen A.; Shelton, Richard C.; Kamali, Masoud; Rabideau, Dustin J.; Shesler, Leah W.; Trivedi, Madhukar H.; McElroy, Susan L.; Sylvia, Louisa G.; Bowden, Charles L.; Ketter, Terence A.; Calabrese, Joseph R.; Thase, Michael E.; Bobo, William V.; Deckersbach, Thilo; Tohen, Mauricio; McInnis, Melvin G.; Kocsis, James H.; Gold, Alexandra K.; Singh, Vishal; Finkelstein, Daniel; Kinrys, Gustavo; Nierenberg, Andrew A.

doi:10.1016/j.jad.2015.12.036

Cited by 23 publications

(25 citation statements)

References 34 publications

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“…This study analyzed for the first time the original structure of the CHRT‐SR 12 with its two subscales and one Total Score. Factor analysis results were similar to those previously reported (Ostacher et al., ; Reilly‐Harrington et al., ; Trivedi et al., ). Trivedi et al., initially reported a 3‐factor structure when testing the CHRT 12 in a sample of patients with MDD: hopelessness, perceived lack of social support, and suicidal thoughts.…”

Section: Discussionsupporting

confidence: 90%

“…() and Reilly‐Harrington et al. () reported a 3‐factor structure when working with a sample of bipolar outpatients, with the last testing a 14‐item version of the CHRT. Consistent with our findings, all previous analyses reported a Suicidal Thoughts factor comprised of the last three items of the scale.…”

Section: Discussionmentioning

confidence: 99%

“…The psychometric properties of the CHRT 12 were first described in an outpatient sample with nonpsychotic Major Depressive Disorder (MDD) receiving pharmacological treatment (Trivedi et al., ). Additionally, the psychometrics has also been reported in outpatients with bipolar disorder receiving pharmacological or nonpharmacological treatment (Ostacher et al., ; Reilly‐Harrington et al., ). This report is the first to address the psychometric properties and the sensitivity of the CHRT 12 to change over 12 weeks in the acute phase treatment of a large representative sample of depressed outpatients.…”

Section: Introductionmentioning

confidence: 99%

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The Concise Health Risk Tracking Self‐Report (CHRT‐SR) assessment of suicidality in depressed outpatients: A psychometric evaluation

Garza

Rush²,

Killian

et al. 2018

Depress Anxiety

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Clinical TrialsCombining Medications to Enhance Depression Outcomes (COMED) https://clinicaltrials.gov/ct2/show/NCT00590 863?term=CO-MED&rank=1 NCT00590863 Background: The 12-item Concise Health Risk Tracking Self-Report (CHRT-SR 12 ) is a brief, selfreport measure that systematically assesses both suicidal thinking and associated thoughts that may indicate the propensity for suicidal acts. It can be used as a tool to both assess risk and guide treatment interventions targeting associated cognitions.Methods: This report used acute treatment data from a clinically representative sample of outpatients with nonpsychotic major depressive disorder (N = 665) participating in the Combining Medications to Enhance Depression Outcomes trial, who received up to 12 weeks of escitalopram, escitalopram plus bupropion SR, or venlafaxine XR plus mirtazapine. Outcome assessors and patients were masked to treatment.Results: Factor analysis of CHRT-SR 12 confirmed that the 12 items have higher order structure with two subscales (Propensity, Suicidal Thoughts) and a total score. Internal consistencies were acceptable for both subscales and total score. All three scales were modestly correlated with overall depression severity (r = 0.54 to r = 0.21) and highly discriminating among patients grouped by suicide item ratings on three different depressive symptom ratings. The three scales also distinguished change over the acute phase treatment for those with different levels of baseline suicidal ideation (measured by 30-item Inventory of Depressive Symptomatology (item 18) and for those with change in suicidal ideation (baseline to last visit). Conclusions:The CHRT-SR 12 has good to excellent psychometric properties and is sensitive to change in suicidal thinking and propensity toward suicidal behavior in outpatients with major depressive disorder. It allows for the monitoring of thoughts and feelings associated with increased suicidal risk as well as levels of thoughts about suicide. K E Y W O R D SConcise Health Risk Tracking Scale (CHRT-SR), depression, psychometrics, suicidal ideation, suicidality, suicide risk

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Concise Health Risk Tracking Self‐Report (CHRT‐SR) assessment of suicidality in depressed outpatients: A psychometric evaluation

Garza

Rush²,

Killian

et al. 2018

Depress Anxiety

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“…= 10.5) were higher than in prior CHRT studies in out-patients (mean = 23.7–25.3) (Ostacher et al . 2015; Reilly-Harrington et al . 2016).…”

Section: Resultsmentioning

confidence: 99%

Psychological interventions to reduce suicidality in high-risk patients with major depression: a randomized controlled trial

et al. 2016

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Background Positive psychological constructs have been associated with reduced suicidal ideation, and interventions to cultivate positive feelings have the potential to reduce suicide risk. This study compares the efficacy of a 6-week, telephone-based positive psychology (PP) intervention against a cognition-focused (CF) control intervention among patients recently hospitalized for depression and suicidal ideation or behavior. Method A total of 65 adults with a current major depressive episode reporting suicidal ideation or a recent suicide attempt were enrolled from participating in-patient psychiatric units. Prior to discharge, participants were randomized to the PP (n = 32) or CF (n = 33) intervention. In both interventions, participants received a treatment manual, performed weekly PP (e.g. gratitude letter) or CF (e.g. recalling daily events) exercises, and completed weekly one-on-one telephone sessions over 6 weeks. Between-group differences in hopelessness (primary outcome), depression, suicidality and positive psychological constructs at 6 and 12 weeks were tested using mixed-effects models accounting for intensity of post-hospitalization psychiatric treatment. Results Compared with PP, the CF intervention was associated with significantly greater improvements in hopelessness at 6 weeks (β = −3.15, 95% confidence interval −6.18 to −0.12, effect size = −0.84, p = 0.04), but not 12 weeks. Similarly, the CF intervention led to greater improvements in depression, suicidal ideation, optimism and gratitude at 6 and 12 weeks. Conclusions Contrary to our hypothesis, the CF intervention was superior to PP in improving hopelessness, other suicide risk factors and positive psychological constructs during a key post-discharge period among suicidal patients with depression. Further study of this CF intervention is warranted in populations at high suicide risk.

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“…Suicide risk assessment is challenging for several reasons. Conventional approaches to risk assessment, for example, suicidal risk scales (Linehan, Comtois, Brown, Heard, & Wagner, ; Nock, Holmberg, Photos, & Michel, ; Reilly‐Harrington et al., ) rely on patient's self‐reporting, but individuals who are truly suicidal often do not share that information. Besides, none of the suicidal risk scales have shown reliable efficiency in determining the suicidal risk, and few have been tested on their predictive ability for suicidal behavior (Roos, Sareen, & Bolton, ).…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA expression in peripheral blood mononuclear cells and suicide risk in Chinese patients with major depressive disorder

et al. 2017

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Background WHO stated that nearly one million people commit suicide every year worldly, and 40% of the suicide completer suffered from depression. The primary aim of this study was to explore the association between long noncoding RNAs (lncRNAs) expression in peripheral blood mononuclear cells (PBMCs) and suicide risk of patients with major depressive disorder (MDD).MethodsUsing Human LncRNA 3.0 microarray profiling which includes 30,586 human lncRNAs and RT‐PCR, six down‐regulated lncRNAs were identified differentially expressed in MDD patients. According to suicidal ideation and suicidal attempt, the suicide risk of MDD patients was classified into suicidal ideation versus no suicidal ideation groups, and past attempt versus no past attempt groups, respectively. The expression of six lncRNAs in MDD patients and controls were examined by RT‐PCR.ResultsThe expression of six lncRNAs had significant differences between no suicidal ideation, suicidal ideation, and controls; corresponding lncRNAs associated with suicidal attempt had remarkable differences between no past attempt, past attempt, and controls. Additionally, only the expression of lncRNAs in suicidal ideation group and past attempt group markedly declined compared with controls.ConclusionsThis study indicated that the expression of six down‐regulated lncRNAs had a negative association with suicide risk in MDD patients, and the expression of lncRNAs in PBMCs could have the potential to help clinician judge the suicide risk of MDD patients to provide timely treatment and prevent suicide.

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A tool to predict suicidal ideation and behavior in bipolar disorder: The Concise Health Risk Tracking Self-Report

Cited by 23 publications

References 34 publications

The Concise Health Risk Tracking Self‐Report (CHRT‐SR) assessment of suicidality in depressed outpatients: A psychometric evaluation

The Concise Health Risk Tracking Self‐Report (CHRT‐SR) assessment of suicidality in depressed outpatients: A psychometric evaluation

Psychological interventions to reduce suicidality in high-risk patients with major depression: a randomized controlled trial

Long noncoding RNA expression in peripheral blood mononuclear cells and suicide risk in Chinese patients with major depressive disorder

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