Long noncoding <scp>RNA</scp> expression in peripheral blood mononuclear cells and suicide risk in Chinese patients with major depressive disorder

Cui, Xia; Niu, Wei; Kong, Lingming; He, Mingjun; Jiang, Kunhong; Chen, Shengdong; Zhong, Aihua; Li, Wanshuai; Lu, Jim; Zhang, Liyi

doi:10.1002/brb3.711

Cited by 29 publications

(23 citation statements)

References 44 publications

(40 reference statements)

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“…Moreover, PSORS1C3 is a known psoriasis susceptibility gene further supporting a role in immune system regulation [34]. Futhermore, a recent study identified six lncRNAs (see Table 2) whose expression was downregulated in peripheral blood samples of MDD patients with SI [99] . Finally, Punzi et al showed that the expression of an uncharacterized lncRNA, LOC285758, is significantly increased in violent suicide cases compared to non-violent suicide cases [100].…”

Section: Non-coding Rnas and Their Role In Sbmentioning

confidence: 94%

Deciphering the Epigenetic Landscape of Suicidal Behaviour: A Review of Current Findings, Caveats and Future Directions

Policicchio¹,

Dempster²,

Murphy³

2018

obm genet

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Suicide is the second leading cause of death globally among young people and the tenth leading cause of death across all ages. Approximately 800,000 people die by suicide every year representing a significant global health burden. Despite this burden, the molecular pathology of suicide remains poorly understood. A number of recent studies have shown that epigenetic alterations are associated with suicidal behaviour. These epigenetic mechanisms, which act to regulate gene expression via modifications to DNA, histone proteins and chromatin, change with age and in response to specific environmental and psychosocial factors-providing a mechanism for the interaction between genotype and the environment. The present review briefly outlines the main epigenetic mechanisms involved in gene regulation and discusses recent findings of epigenetic alterations in suicidal behaviour, their caveats and the future direction of this emerging field of research.

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Section: Non-coding Rnas and Their Role In Sbmentioning

confidence: 94%

Deciphering the Epigenetic Landscape of Suicidal Behaviour: A Review of Current Findings, Caveats and Future Directions

Policicchio¹,

Dempster²,

Murphy³

2018

obm genet

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“…TEs represent important sources of epigenetic regulation (Mustafin, Khusnutdinova, 2017), thus providing their study as a promising direction for identifying the mechanisms of SB development. A differential expression of six lncRNAs (TCONS_00019174, ENST00000566208, NONHSAG045500, ENST00000517573, NONHSAT034045, and NONHSAT142707) was observed in peripheral blood leukocytes of patients with SB and MDD (Cui et al, 2017), while 23 different lncRNAs were differentially expressed in the brains of individuals with completed suicide (Zhou et al, 2018) compared to the control group. Protein-encoding genes localized distally from lncRNAs identified in these studies are involved in the organization of the cytoskeleton and plasmatic membrane, cell adhesion, DNA binding and regulation of dendrite development (Zhou et al, 2018).…”

Section: The Role Of Long Non-coding Rnasmentioning

confidence: 97%

“…These results promote further research of lncRNAs, which makes it possible to develop effective methods for SB prevention and therapy. Analysis of lncRNAs differentially expressed in SB (TCONS_00019174, ENST00000566208, NONHSAG045500, ENST00000517573, NONHSAT034045, and NONHSAT142707) has been proposed as a potential diagnostic and therapeutic SB biomarker for the prevention of suicidal attempts in MDD patients (Cui et al, 2017). The changes in miRNA expression identified in the brain of individuals with completed suicide can represent the basis for both clarifying SB pathogenesis and developing a targeted SB therapy (Maussion et al, 2012;Smalheiser et al, 2012;.…”

Section: Prospects For Epigenetic Studies Of Suicidal Behaviormentioning

confidence: 99%

“…Every 40 seconds in the world 1 individual dies from suicide . According to the WHO, about 1 million individuals commit suicide every year (Cui et al, 2017), and the global prevalence of suicide is 11.4 per 100,000 individuals (Lutz et al, 2017). Suicidal behavior (SB) is a generic term used to denote risk, attempts and committed suicide (Bani-Fatemi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Epigenetics of suicidal behavior

et al. 2019

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Suicide is the second leading cause of death among young people and therefore being a serious global problem worldwide. The study of genetic and epigenetic factors in the development of suicidal behavior plays an important role in the development of advanced methods of diagnosis and treatment of this pathology. The role of hereditary factors in the development of suicidal behavior is estimated at 30–55 %, with a pronounced comorbidity with other psychopathologies. The study of genetic liability to suicidal behavior is based on molecular-genetic methods including association and linkage analyses, chip gene expression arrays, and genome-wide association studies. Published data identified multiple genes including those involved in the functioning of serotonergic (SLC6A4, TPH, 5-HT1A), hypothalamic-pituitary-adrenal systems (FKBP5) and polyamines (SAT and OATL1) associated with suicidal behavior. However, the diversity of interacting genetic loci complicates the interpretation of the development of a complex phenotype of pathology and prevents the association from being detected. To solve this problem and interpret the missing relationship between the environment and the genome, promising results were obtained from a study of epigenetic factors, which affected the expression of a number of candidate genes involved in brain functioning in suicidal behavior. The analysis of a brain obtained from suicide victims, representing a unique tool for the analysis of modified genomic processes, revealed a wide range of reprogramming patterns of DNA methylation in promoters of the genes of polyamine (OAZ1, OAZ2, AMD1, ARG2, SKA2), serotonergic (SLC6A4) and GABAergic (GABRA1) systems, HPA-axis (GR, NR3C1), tyrosine kinase (TrkB) receptors, brain-derived neurotrophic factor (BDNF). The role of histone modifications in distinct genes (Cx30, Cx43, TrkB.T1) and the expression of specific long noncoding RNAs and microRNAs in the development of suicidal behavior, which is promising for the development of diagnostic algorithms and target therapy, is discussed.

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“…Our previous studies showed that 6 lncRNAs (TCONS_00019174, ENST00000566208, NONHSAG045500, ENST00000517573, NONHSAT034045, and NONHSAT142707) had diagnostic value, therapeutic evaluation, differential diagnosis, and participated in many functions in the central nervous system [ 19 ]. The expression of 6 lncRNAs was significantly correlated with suicide risk [ 20 ]. This study aimed to investigate whether 3 candidate differentially expressed lncRNAs (NONHSAT142707, NONHSAG045500, ENST00000517573) in MDD, which have much higher expression in the brain, can internalize SERT and reduce SERT-binding sites through mediating SERT mRNA levels in SK-N-SH cells.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Antidepressant Potential of NONHSAG045500 in Regulating Serotonin Transporter in Major Depressive Disorder

et al. 2018

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BackgroundMajor depressive disorder (MDD) is a chronic, life-threatening, highly disabling disease. Standardized treatment with fewer adverse effects, quick onset, and long-term maintenance of the effects of brief treatment for MDD is always being pursued. Long non-coding RNAs (lncRNAs) are highly expressed in the central nervous system and are involved in the occurrence and development of neurodegenerative and psychiatric diseases. This study aimed to investigate whether the overexpression and interference of 3 differentially down-regulated lncRNAs (NONHSAT142707, NONHSAG045500, and ENST00000517573) in MDD can affect the expression of central neurotransmitter serotonin (5-hydroxytryptamine) transporter (SERT) in vitro.Material/MethodsFirst, we synthesized and validated the effect of 3 lncRNA plasmids and small interfering RNAs (siRNAs); next, we transfected the plasmids and siRNAs that caused significant overexpression or interference in SK-N-SH cells, and tested the expression of SERT by qRT-PCR.ResultsThe results showed that 3 lncRNA plasmids and siRNAs2 caused overexpression and interference, respectively. Only the overexpression of NONHSAG045500 could significantly inhibit the expression of SERT; interference with NONHSAG045500 could significantly strengthen the expression of SERT.ConclusionsThis study indicated that the expression of SERT could be regulated by up-regulating or down-regulating NONHSAG045500 expression and suggested that NONHSAG045500 could potentially be established as a new therapeutic target of MDD. Future work may be needed to definitively determine the correlation between NONHSAG045500 and SERT in vivo.

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Long noncoding RNA expression in peripheral blood mononuclear cells and suicide risk in Chinese patients with major depressive disorder

Cited by 29 publications

References 44 publications

Deciphering the Epigenetic Landscape of Suicidal Behaviour: A Review of Current Findings, Caveats and Future Directions

Deciphering the Epigenetic Landscape of Suicidal Behaviour: A Review of Current Findings, Caveats and Future Directions

Epigenetics of suicidal behavior

Therapeutic Antidepressant Potential of NONHSAG045500 in Regulating Serotonin Transporter in Major Depressive Disorder

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