A Threat of the Klebsiella Pneumoniae Carbapenemase–Producing Strains Among Transplant Recipients

Klebsiella necrotizing soft tissue infections in liver transplant recipients: a case series

“…The emergence of CRKP in the last decade has become increasingly concerning and is now viewed as a public health threat . CRKP infections in the SOT population have now been reported worldwide and have been associated with poor clinical outcomes including allograft rejection and high mortality . Therefore, the importance of implementing key infection control measures to prevent transmission of CRE cannot be understated.…”

Carbapenem-resistant Enterobacteriaceae in special populations: Solid organ transplant recipients, stem cell transplant recipients, and patients with hematologic malignancies

“…Furthermore, CRE infections in liver transplant recipients have been reported as the index cases of CRE in hospital outbreaks. 32,87 In 2012, the Centers for Disease Control and Prevention (CDC) published a toolkit providing guidance on the prevention of CRE in healthcare facilities. Updated recommendations in November 2015 included optimizing compliance with hand hygiene and contact precautions, healthcare personnel education, minimizing the use of indwelling devices such as central venous catheters, endotracheal tubes, and urinary catheters, antimicrobial stewardship, environmental cleaning, patient and staff cohorting, screening contacts of CRE patients, active surveillance, and chlorhexidine bathing.…”

“…Such measures have been successful in controlling outbreaks of CRE in liver transplantation units. 87,88 The update also stressed the importance of inter-facility communication, 89 which was shown to be a critical component of successful management of organ transplant recipients from a donor infected with CRKP. 43 Following the 2 recent CRE outbreaks related to contaminated duodenoscopes in the United States and during which one kidney-pancreas transplant recipient died, 90,91 the CDC has also provided guidance on surveillance for bacterial contamination of duodenoscopes after reprocessing.…”

Molecular Analysis of Carbapenem-resistant Strains of Pseudomonas aeruginosa Isolated From Patients Hospitalized in Various Transplantation Wards Between 2008 and 2011

“…However, the increasing use of carbapenems results in the continuous increase in the number of carbapenem-resistant strains. In Enterobacteriaceae, these resistance-inducing enzymes include both metalloenzymes, and the serine KPC-type carbapenemases [8]. Of the CRPA strains analyzed as part of our study, 68% strains showed the presence of VIM carbapenemase, which has been the most commonly isolated carbapenemase in Poland thus far.…”