A thermosensitive chitosan-based hydrogel barrier for post-operative adhesions' prevention

Peritoneal adhesion prevention by a biodegradable hyaluronic acid-based hydrogel formed in situ through a cascade enzyme reaction initiated by contact with body fluid on tissue surfaces

“…One involves initiation of hydrogelation by mixing multiple cross-linkable precursor solutions immediately before application [8][9][10][11]. The other type initiates hydrogelation on the surface of the administered surface [12][13][14]. This system is simpler than the former type.…”

“…For preformed solid films and membranes, it is difficult to cover injured surfaces with a complex geometry and extensive survey surface. A recent promising approach employs in situ cross-linkable hydrogels that can form hydrogels when applied in situ [8][9][10][11][12][13][14]. This strategy has advantages over approaches using polymer solutions and preformed solid films.…”

“…Recently, barrier-based approaches have attracted significant attention to prevent peritoneal adhesions. Polymer solutions [4,5], preformed solid films and membranes [6,7], and hydrogels [8][9][10][11][12][13][14][15][16] have been investigated for these approaches. Polymer solutions are useful to cover injured surfaces even with a complex geometry.…”

A Comparative Study of the Preventive Effects of Mitomycin C and Chitosan on Intraarticular Adhesion after Knee Surgery in Rabbits

“…Chitosan can inhibit fibroblast proliferation, decrease the fibroblast migration rate, and induce fibroblasts to secrete collagenase. Thus, the synthesis of collagenous fiber slows down and the collagen degradation takes place which is helpful in reducing fibrous tissue adhesion [19,20]. In addition, chitosan fills in tissue wounds, reduces hemorrhage at wound surface, prevents joint bleeding and hemorrhage organization as well as inhibits intraarticular adhesion [21,22].…”

Preparation of Chitosan Beads for Trypsin Immobilization

“…As enzyme immobilization matrices, chitosanbased materials are used in the form of powders (23), flakes and gels of different geometrical configurations (37,40). Preparation of chitosan gels is promoted by the fact that chitosan dissolves in dilute solutions of organic acids (formic, acetic and citric acids) to form viscous solutions that precipitate in high pH solution and form waterinsoluble complexes.…”