A thermo/pH/magnetic-responsive nanogel based on sodium alginate by modifying magnetic graphene oxide: Preparation, characterization, and drug delivery

Sang, Golnaz; Bardajee, Ghasem Rezanejade; Mirshokraie, Ahmad; Didehban, Khadijeh

doi:10.1007/s13726-017-0592-3

Cited by 23 publications

(7 citation statements)

References 27 publications

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“… 48 Superparamagnetism, which is the ability to become magnetized when a magnetic field is applied but has no permanent magnetization (remanence) after the magnetic field is removed, plays a crucial role for many important applications such as drug delivery, magnetically targeted therapy, magnetic resonance imaging, magnetic separation, etc. 46 , 49 At the plateau, i.e., an applied magnetic field of ∼2.3–20 kOe range, the induced magnetization in the superparamagnetic hydrogel, PAAVSA/Fe 3 O 4 , is found to be about 1.4–1.8 emu/g at room temperature, which is very much compatible for the above-mentioned applications. 46 , 49 However, at room temperature, the pristine Fe 3 O 4 nanoparticles exhibit induced magnetization of 41.3–57.7 emu/g at the plateau (at H ∼2.3–20 kOe), which is consistent with the reported results in the literature.…”

Section: Results and Discussionmentioning

confidence: 84%

“… 46 , 49 At the plateau, i.e., an applied magnetic field of ∼2.3–20 kOe range, the induced magnetization in the superparamagnetic hydrogel, PAAVSA/Fe 3 O 4 , is found to be about 1.4–1.8 emu/g at room temperature, which is very much compatible for the above-mentioned applications. 46 , 49 However, at room temperature, the pristine Fe 3 O 4 nanoparticles exhibit induced magnetization of 41.3–57.7 emu/g at the plateau (at H ∼2.3–20 kOe), which is consistent with the reported results in the literature. 50 The results indicate a reduction in saturation magnetization of PAAVSA/Fe 3 O 4 with respect to that of pristine Fe 3 O 4 , which mainly results from the embedded and dispersed Fe 3 O 4 nanoparticles in the PAAVSA/Fe 3 O 4 system, and the reduction amount implies that the system contains about 3 wt % Fe 3 O 4 nanoparticles.…”

Section: Results and Discussionmentioning

confidence: 84%

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Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

2020

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Superparamagnetism has been widely used for many biomedical applications, such as early detection of inflammatory cancer and diabetes, magnetic resonance imaging (MRI), hyperthermia, etc., whereas incorporation of superparamagnetism in stimulus-responsive hydrogels has now gained substantial interest and attention for application in these fields. Recently, pH-responsive superparamagnetic hydrogels showing the potential use in disease diagnosis, biosensors, polymeric drug carriers, and implantable devices, have been developed based on the fact that pH is an important environmental factor in the body and some disease states manifest themselves by a change in the pH value. However, improvement in pH sensitivity of magnetic hydrogels is a dire need for their practical applications. In this study, we report the distinctly high pH sensitivity of new synthesized dual-responsive magnetic hydrogel nanocomposites, which was accomplished by copolymerization (free-radical polymerization) of two pH-sensitive monomers, acrylic acid (AA) and vinylsulfonic acid (VSA) with an optimum ratio, in the presence of presynthesized superparamagnetic iron oxide nanoparticles (Fe 3 O 4 (OH) x ). The monomers contain pH-sensitive functional groups (COO – and SO 3 – for AA and VSA, respectively), and they have also been widely used as biomaterials because of the good biocompatibility. The pH sensitivity of the superparamagnetic hydrogel, poly(acrylic acid- co -vinylsulfonic acid), PAAVSA/Fe 3 O 4 , was investigated by swelling studies at different pH values from pH 7 to 1.4. Distinct pH reversibility of the system was also demonstrated through swelling/deswelling analysis. Thermal stability, chemical configuration, magnetic response, and structural properties of the system have been explored by suitable characterization techniques. Furthermore, the study reveals a pH-responsive significant change in the overall morphology and packing fraction of iron oxide nanoparticles in PAAVSA/Fe 3 O 4 via energy-dispersive X-ray (EDX) elemental mapping with the field emission scanning electron microscopy (FESEM) study (for freeze-dried PAAVSA/Fe 3 O 4 , swelled at different pH values), implying a drastic change in susceptibility and induced saturation magnetization of the system. These important features could be easily utilized for the purpose of diagnosis using magnetic probe and/or impedance analysis techniques.

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Section: Results and Discussionmentioning

confidence: 84%

Section: Results and Discussionmentioning

confidence: 84%

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

2020

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“…A novel magnetic thermal/pH-responsive nanogels (PNIPAM- co -PAA)/SA-MGO) were prepared by grafting AA and NIPAM onto sodium AG to modify magnetic graphene oxide, which can be applied for drug (DOX) delivery . The DOX-loaded triple-responsive nanogel exhibited excellent reversible transmittance changes with magnetic field, temperature, and pH.…”

Section: Multiresponsive Nanogels For Cancer Therapymentioning

confidence: 99%

Strategic Design of Intelligent-Responsive Nanogel Carriers for Cancer Therapy

Wang

Gao

Fan

et al. 2021

ACS Appl. Mater. Interfaces

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Owing to the distinctive constituents of tumor tissue from those healthy organs, nanomedicine strategies show significant potentials in smart drug delivery. Nowadays, stimuli-responsive nanogels are playing increasingly important roles in the application of cancer therapy because of their sensitivity to various internal or external physicochemical stimuli, which exhibit site-specific and markedly enhanced drug release. Besides, nanogels are promising as drug carriers because of their porous structures, good biocompatibility, large surface area, and excellent capability with drugs. Taking advantage of multiresponsiveness, recent years have witnessed the rapid evolution of stimulus-responsive nanogels from monoresponsive to multiresponsive systems; however, there lacks a comprehensive review summarizing these reports. In this Review, we discuss the properties, synthesis, and characterization of nanogels. Moreover, tumor microenvironment and corresponding designing strategies for stimuli-response nanogels, both exogenous (temperature, magnetic field, light) and endogenous (pH, biomolecular, redox, ROS, pressure, hypoxia) are summarized on the basis of the recent advances in multistimuli-responsive nanogel systems. Nanogel and two-dimensional material composites show excellent performance in the field of constructing multistimulus-responsive nanoparticles and precise intelligent drug release integrated system for multimodal cancer diagnosis and therapy. Finally, potential progresses and suggestions are provided for the further design of hybrid nanogels based on emerging two-dimensional materials.

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“…6,7 Nanoparticles as carrier systems have great potential for treating tuberculosis (TB). 8,9 Their high carrier capacity, great stability, and feasibility of variable ways of administration, including oral application and inhalation, which can be mentioned as the most significant scientific benefits of nanoparticles used as drug carriers. 10,11 Moreover, nanoparticles can be planned to create a sustained drug release.…”

Section: Introductionmentioning

confidence: 99%

Molecular Dynamics Simulation, Characterization and In Vitro Drug Release of Isoniazid Loaded Poly-ε-caprolactone Magnetite Nanocomposite

et al. 2020

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Background: This study reports on the development of a controlled-release isoniazid (INH) drug delivery system using poly-є-caprolactone (PCL) functionalized magnetite-nanoparticles (MNPs), as a theoretical potential tool for tuberculosis (TB) chemotherapy. Method: The magnetite Fe3O4 core was fabricated by the co-precipitation method and coated with PCL by emulsion polymerization. INH was loaded onto the PCL-MNP surface to shape an INH-PCL-MNP nanocomposite. Deposing the INH on the nanocomposite surface was demonstrated through the molecular dynamics simulations. To investigate the stability of the polymer, the root-mean-square deviation (RMSD) and the radius of gyration (Rg) were calculated. The composite was characterized by Scanning electron microscopy (SEM) and X-Ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). Mycobacterium tuberculosis was used to assess the antimicrobial activity of the nanoparticles. The drug loading efficiency, drug content, and in-vitro release behavior of the INH-PCL-MNPs were evaluated by UV–Vis spectrophotometry. Results: RMSD of PCL show that the structure of polymer after 40 ns is stable. INH molecules interested to spend more time close to the polymer. Rg of PCL indicated that PCL folded and radius of gyration changed near 1nm. The drug loading efficiency and drug content of the NPs were 720±46 mg/g and 69.3±3.8 (%), respectively. The compound showed a strong level of activity in-vitro. The amount of drug release at all times was above the minimum inhibitory concentration (MIC) (6 μg/ml). Conclusion: INH-PCL-MNP nanocomposite have been effectively used as a potential tool to treat TB infections and a magnetic drug carrier system.

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A thermo/pH/magnetic-responsive nanogel based on sodium alginate by modifying magnetic graphene oxide: Preparation, characterization, and drug delivery

Cited by 23 publications

References 27 publications

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

Strategic Design of Intelligent-Responsive Nanogel Carriers for Cancer Therapy

Molecular Dynamics Simulation, Characterization and In Vitro Drug Release of Isoniazid Loaded Poly-ε-caprolactone Magnetite Nanocomposite

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