A theranostic system based on nanocomposites of manganese oxide nanoparticles and a pH sensitive polymer: Preparation, and physicochemical characterization

Foroushani, Marzieh Samiei; Niroumand, Nazanin; Shervedani, Reza Karimi; Kefayat, Amirhosein; Torabi, Mostafa

doi:10.1016/j.bioelechem.2019.107347

Cited by 20 publications

(10 citation statements)

References 55 publications

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“…[16][17][18]. It is reported that poly(N-isopropylacrylamide) (PNIPAM) and polyacrylic acid (PAA) microgels are typical temperature-sensitive and pH-sensitive microgels, respectively [19][20][21]. The poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAMco-PAA) microgels are biological smart polymers formed by the monomer acrylic acid (AA) and N-isopropylacrylamide (NIPAM) through the aqueous emulsion polymerization.…”

Section: Introductionmentioning

confidence: 99%

Tribological behavior of thermal- and pH-sensitive microgels under steel/CoCrMo alloy contacts

Sun

Dong

et al. 2022

Friction

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The tribological behavior of 316L stainless steel/CoCrMo alloy contacts under aqueous lubrication was investigated in this work. Three types of microgels including poly(N-isopropylacrylamide) (PNIPAM), polyacrylic acid (PAA), and poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-co-PAA) were prepared and used as lubricant additives in aqueous solutions. Tribological tests were conducted using a ball-on-disk reciprocating tribometer, over a range of temperatures, pH, and concentrations of the microgels. The PNIPAM-co-PAA microgels were proven to have excellent anti-friction and anti-wear properties, depending on the temperature and pH values of the solutions. The maximum friction coefficient coincided with the lower critical solution temperature of the PNIPAM-co-PAA microgels at 32 °C. At the same time, the friction coefficient increased with the increase in pH value of the lubricant solution with the PNIPAM-co-PAA microgels. The unique thermal- and pH-sensitive properties of the PNIPAM-co-PAA microgels provided a new strategy for controlling the friction and wear of steel/CoCrMo alloy contacts under aqueous lubrication.

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Section: Introductionmentioning

confidence: 99%

Tribological behavior of thermal- and pH-sensitive microgels under steel/CoCrMo alloy contacts

Sun

Dong

et al. 2022

Friction

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“…In this work, both in vivo and in vitro FA-conjugated nanoparticles showed better targeting to activated macrophages. The FA modification is an effective method for the targeted delivery of therapeutic agents to cells expressing FA receptors. − Moreover, the targeting effect is more obvious after the introduction of US and MB. This may be related to the fact that MB can amplify the cavitation effect of US, leading to a significant sonoporation, − which causes a significant increase in the permeability of cell membranes and vessel walls .…”

Section: Resultsmentioning

confidence: 99%

Ultrasound-Targeted Microbubble Destruction-Mediated Cell-Mimetic Nanodrugs for Treating Rheumatoid Arthritis

Guo

Wang

Huang

et al. 2023

ACS Biomater. Sci. Eng.

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Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects joints, and it can lead to disability and damage to vital organs if not diagnosed and treated in time. However, all current therapeutic agents for RA have limitations such as high dose, severe side effects, long-term use, and unsatisfactory therapeutic effects. The long-term use and dose escalation of methotrexate (MTX) may cause mild and severe side effects. To overcome the limitations, it is critical to target drug delivery to the inflamed joints. In this work, we constructed a folic acidtargeted and cell-mimetic nanodrug, MTX-loaded mesoporous silica composite nanoplatform (MMPRF), which can regulate drug release under ultrasound (US) and microbubble (MB) mediation. The targeted delivery and drug therapy were investigated through in vitro RAW264.7 cell experiments and in vivo collageninduced arthritis animal experiments. The result showed that the targeting ability to the joints of MMPRF was strong and was more significant after US and MB mediation, which can potently reduce joint swelling, bone erosion, and inflammation in joints. This work indicated that the US-and MB-mediated MMPRF not only would be a promising method for synergistic targeted treatment of RA but also may show high potential for serving as a nanomedicine for many other biomedical fields.

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“…Marzieh Samiei Foroushani et al presented a multifunctional theranostic structure constructed of manganese oxide (Mn 3 O 4 ) NPs, covered with PAA, and loaded with methotrexate targeting agent and anticancer drug. PAA, a pH-sensitive agent for loading and delivery of MTX, can improve MTX accumulation in tumor sites [ 107 ].…”

Section: Bio-conjugation With Other Materialsmentioning

confidence: 99%

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

et al. 2022

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Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that gained lots of interest in recent years. PAA nano-derivatives can be obtained by chemical modification of carboxyl groups with superior chemical properties in comparison to unmodified PAA. For example, nano-particles produced from PAA derivatives can be used to deliver drugs due to their stability and biocompatibility. PAA and its nanoconjugates could also be regarded as stimuli-responsive platforms that make them ideal for drug delivery and antimicrobial applications. These properties make PAA a good candidate for conventional and novel drug carrier systems. Here, we started with synthesis approaches, structure characteristics, and other architectures of PAA nanoplatforms. Then, different conjugations of PAA/nanostructures and their potential in various fields of nanomedicine such as antimicrobial, anticancer, imaging, biosensor, and tissue engineering were discussed. Finally, biocompatibility and challenges of PAA nanoplatforms were highlighted. This review will provide fundamental knowledge and current information connected to the PAA nanoplatforms and their applications in biological fields for a broad audience of researchers, engineers, and newcomers. In this light, PAA nanoplatforms could have great potential for the research and development of new nano vaccines and nano drugs in the future.

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A theranostic system based on nanocomposites of manganese oxide nanoparticles and a pH sensitive polymer: Preparation, and physicochemical characterization

Cited by 20 publications

References 55 publications

Tribological behavior of thermal- and pH-sensitive microgels under steel/CoCrMo alloy contacts

Tribological behavior of thermal- and pH-sensitive microgels under steel/CoCrMo alloy contacts

Ultrasound-Targeted Microbubble Destruction-Mediated Cell-Mimetic Nanodrugs for Treating Rheumatoid Arthritis

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

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