A theoretical study of the antioxidant properties of phenolic acid amides investigated through the radical-scavenging and metal chelation mechanisms

Kabanda, Mwadham M.

doi:10.1007/s00217-015-2484-0

Cited by 15 publications

(4 citation statements)

References 85 publications

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“…The metalligand interaction has characteristics that represent the mix of shared interactions (strong bonds) and closed-shell interactions (weak bonds). In such systems, the value of H is usually negative and close to zero, as found for strong interactions, but with a positive value of ∇ 2 ρ, which is a characteristic of weak interactions [75,76]. Another parameter that is utilised in the characterisation of the bonding is the |V|/G ratio: |V|/G < 1 represents closed-shell interactions; |V|/G > 2 represents shared interactions; 1 < |V|/G < 2 represents interactions of intermediate character [77,78].…”

Section: Aim Analysis Of the M 2+ ···Ligand Bonding: Results In Vacuomentioning

confidence: 94%

Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution

Serobatse

Kabanda

2015

Eur Food Res Technol

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and lowest for the Fe coordination on the π system of the aromatic ring). The charge on Fe n+ decreases on coordination to the ligand. AIM analysis suggests that the strong cation···ligand interactions are more likely covalent than ionic in vacuo and entirely ionic in solution. The ability of the ligands to reduce the Fe cation coupled with the strong iron-binding properties has significant implication on their antioxidant and antimalarial activities.

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Section: Aim Analysis Of the M 2+ ···Ligand Bonding: Results In Vacuomentioning

confidence: 94%

Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution

Serobatse

Kabanda

2015

Eur Food Res Technol

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“…The potential health-promoting properties of PAs are wide and considered as health-promoting food ingredients since they occur in elevated concentrations in edible produce products such as eggplant (Solanum melongena L.), tomato (Solanum lycopersicum L.), cocoa (Theobroma cacao L.), and oat (Avena sativa L.) (Roumani et al, 2020). Their reported biological activities include hypotensive activity (Forero et al, 2016), anti-inflammatory (Kim et al, 2012), antioxidant (Kabanda, 2015), antimicrobial (Michalet et al, 2007), and anti-cancer (Rocha et al, 2012) properties together with activities protecting humans from metabolic ailments, and cardiovascular and neurodegenerative diseases (Xie et al, 2007). In the context of PAs as health promoting plant metabolite, the N1, N10-diferuloylspermidine in pineapple has potential to lower cholesterol biosynthesis via HMGCR inhibition activity.…”

Section: Discussionmentioning

confidence: 99%

In situ spatiotemporal mapping of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibitor in pineapple (Ananas comosus) fruit tissue by MALDI mass spectrometry imaging

Suarez

Juanillo

Sison³

et al. 2023

Front. Nat. Prod.

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Pineapple (Ananas comosus) fruit is a functional food that has become a part of healthy diets worldwide due to its nutrition and health benefits. Given this concept, the potential anti-hypercholesterolemic activity of pineapple fruit was assessed using in vitro HMG-CoA reductase (HMGCR) inhibition assay. Our findings show that pineapple fruit (PAF) extract showed HMGCR inhibition activity. These findings led to partial purification of PAF extract by gel filtration chromatography (GFC) whereby fraction PAF 06 exhibited 100.00% HMGCR inhibition at 10 mg/mL. Matrix assisted laser desorption ionization (MALDI) mass spectrometry profiling, HRMS, MS/MS, and dereplication identified N1, N10-diferuloylspermidine as potential HMGCR inhibitor in pineapple fruit. The MALDI mass spectrometry imaging (MSI) enabled the in situ spatiotemporal mapping of the HMGCR inhibitor, N1, N10-diferuloylspermidine, in the pineapple fruit tissue, with localization concentrated mainly in the tissue near the peel/shell and a gradual decrease towards the flesh and ovary. The MALDI MSI provided the first evidence of in situ spatial localization of N1, N10-diferuloylspermidine, a potential HMGCR inhibitor in pineapple while maintaining the cellular and structural features of the fruit tissues.

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“…Oat polyphenols have been well reported for their pharmacological benefits including antioxidant activities. The polyphenolic combination with different groups such as phenolamide tends to potentiate its action [57][58][59]. Avns have been found to exhibit antioxidant and anti-inflammatory effects in the CNS, which can be beneficial for reducing stress and neuroinflammation associated with various neurological conditions.…”

Section: Neuroprotective Role Of Avnsmentioning

confidence: 99%

Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases

Wankhede,

Kale,

Bawankule

et al. 2023

Nutrients

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Avenanthramides (Avns) and their derivatives, a group of polyphenolic compounds found abundantly in oats (Avena sativa Linn.), have emerged as promising candidates for neuroprotection due to their immense antioxidant, anti-inflammatory, and anti-apoptotic properties. Neurodegenerative diseases (NDDs), characterized by the progressive degeneration of neurons, present a significant global health burden with limited therapeutic options. The phosphoinositide 3-kinase (PI3K) signaling pathway plays a crucial role in cell survival, growth, and metabolism, making it an attractive target for therapeutic intervention. The dysregulation of PI3K signaling has been implicated in the pathogenesis of various NDDs including Alzheimer’s and Parkinson’s disease. Avns have been shown to modulate PI3K/AKT signaling, leading to increased neuronal survival, reduced oxidative stress, and improved cognitive function. This review explores the potential of Avn polyphenols as modulators of the PI3K signaling pathway, focusing on their beneficial effects against NDDs. Further, we outline the need for clinical exploration to elucidate the specific mechanisms of Avn action on the PI3K/AKT pathway and its potential interactions with other signaling cascades involved in neurodegeneration. Based on the available literature, using relevant keywords from Google Scholar, PubMed, Scopus, Science Direct, and Web of Science, our review emphasizes the potential of using Avns as a therapeutic strategy for NDDs and warrants further investigation and clinical exploration.

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A theoretical study of the antioxidant properties of phenolic acid amides investigated through the radical-scavenging and metal chelation mechanisms

Cited by 15 publications

References 85 publications

Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution

Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution

In situ spatiotemporal mapping of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibitor in pineapple (Ananas comosus) fruit tissue by MALDI mass spectrometry imaging

Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases

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