A theoretical study of the intramolecular proton transfer and calculation of the nucleus independent chemical shift in juglone and some of its derivatives

Abstract

In the present study, first, the intramolecular proton transfer (IPT) process of juglone and its derivatives were theoretically investigated in the gas phase and the effect of electron-withdrawing and electron-releasing substituents in different positions of the phenyl and benzoquinone rings of juglone on the IPT process was studied in which the geometries, energies and thermodynamic functions of the compounds were obtained using density functional theory (DFT) calculations at the B3LYP/6-31+G(2d,p) level. Next, the influence of IPT on changing the aromaticity of the phenyl and benzoquinone rings was investigated. To determine the aromaticity of the rings, nuclear independent chemical shift (NICS) values were calculated for the ground state and transition state structures (GS 1 , TS and GS 2 ) using the continues set of gauge transformations (CSGT) procedure at the B3LYP/6-311+G(2d,p) level.

Electron attachment to some naphthoquinone derivatives: long‐lived molecular anion formation

“…Many quinones exhibit an interesting range of pharmacological properties, such as antibacterial, antifungal, antiviral, anti‐inflammatory, enzyme‐inhibitive, antioxidant or radical scavenging properties. Ubiquinone and vitamin K (a derivative of 1,4‐naphthoquinone) play a crucial role in the electron transfer process of the cell respiratory system of mammals . Theoretical calculations have been used only recently to characterize their electronic structures and the energetics of proton transfer and hydrogen abstraction processes, with the aim of correlating calculated quantities with their biological activities .…”