A tethering system for intravenous and intragastric drug administration in the baboon

Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboons

“…The baboons had been implanted with IG catheters using methods described previously (Lukas et al 1982), and had participated in a study evaluating the effects of acute doses of GHB and potential antagonists (Goodwin et al in press) before beginning the current study. Prior to that study, baboons HA and PF were experimentally naive.…”

The adenosine receptor antagonist CGS15943 reinstates cocaine-seeking behavior and maintains self-administration in baboons

“…The catheter was protected by a tether/harness/vest system that permitted the baboon free movement inside the cage. Procedures for the catheter implant surgery and description of the tether/harness/vest system have been described previously (Lukas et al 1982). The catheters for AD, ZA, JP and DM were implanted 2-3 weeks before cocaine or food self-administration training for the current study (see below).…”

Relation between discriminative and reinforcing effects of midazolam, pentobarbital, chlordiazepoxide, zolpidem, and imidazenil in baboons

“…Each baboon was fitted with a vest and tether. This equipment and the pump system used to deliver drug were described in Lukas et al (1982). Control of experimental conditions and data collection was by computers programmed in state notation.…”