A test microchip for evaluation of hermetic packaging technology for biomedical prosthetic implants

Abstract

Abstract-The development of a test chip that will be used to evaluate a hermetic and biocompatible package for the driving CMOS circuitry of a retinal prosthesis is described. The package design is estimated to be about 2 x 2 x 0.3 mm 3 and will be formed by conformal layers of parylene and a metal (e.g. titanium) as inner and outer protections, respectively. The test chip has been specifically designed for evaluation of the packaging technology. It consists of many blocks of analog and digital components as well as relative humidity and temperature sensors. The test chip has more probe points than a typical chip, allowing a more thorough evaluation of circuit behavior during the testing. This chip will first be coated in a layer of parylene C and soaked in heated isotonic saline for an extended period of time. Every block in the chip will then be tested for functionality using the surface probe points. The next step is to coat the surface of another test chip with parylene and a metal and repeat these soak tests. The results will then be analyzed and mean time-to-failure for the different samples will then be computed. Using the accelerated testing paradigm, these results will then be extrapolated to mean time-to-failure in the operating intraocular environment. Parylene test structures have already undergone an accelerated lifetime test and results have been analyzed.

Electrically-evoked Neural Activities of rd1 Mice Retinal Ganglion Cells by Repetitive Pulse Stimulation

“…Various efforts toward implementation of visual prosthetic device have involved development of suitable electrodes, circuitry, packaging, and surgical implantation techniques (Hesse et al, 2000;Kazemi et al, 2004;Seo et al, 2004;Sivaprakasam et al, 2005).…”

Advancement in Nanostructure-Based Tissue-Engineered Biomaterials for Retinal Degenerative Diseases

“…It has a low permeability, high tensile strength, moisture and dielectric barrier properties. Among the most commonly used parylenes is parylene C, it is inert, clear, hydrophobic and biocompatible [140].…”

Reliability Enhancement of ACF Joined Flip Chips with Parylene C as a Protective Coating

“…Typically especially in implantable applications metal casings are used, and only flexible parts of the devices are coated with some polymer [3]. However, in applications with limited implantation time, also polymer materials are used [4]. The challenge in the use of polymers as protective coating materials lies in the non-hermetic shield that they are giving.…”