A temporal trend study (1972–2008) of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in pooled human milk samples from Stockholm, Sweden

Sundström, Maria; Ehresman, David J.; Bignert, Anders; Butenhoff, John L.; Olsen, Geary W.; Chang, Shu‐Ching; Bergman, Åke

doi:10.1016/j.envint.2010.08.014

Cited by 137 publications

(93 citation statements)

References 27 publications

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“…This relative trend was similar to what was observed in Norwegian males, where a significant change-point was observed in 1993 [92]. The shape of these two human temporal trends [92,137] closely mirrors the trend in annual production volumes of PFOS reported by Paul et al [5] and as plotted in our associated review protocol [9]. Three datasets from Swedish dietary items [99] were also analyzed for change points, but no change points were detected.…”

Section: Pfos Change Point Analysismentioning

confidence: 54%

“…Among datasets with a significant change point, only 2 of 8 showed a significant increasing trend prior to the change point [92,137], while 6 of 8 showed no significant trend before the change point, but all of these were statistically underpowered. The two datasets showing an increasing trend prior to the change point were also the datasets with the oldest archived samples; showing an increasing trend in adult male serum from Norway between 1978 and 1993 [92] and in primiparous female serum from Stockholm, Sweden between 1972 and 1988 [137]. Consistently, all of the studies with a change point (8/8) showed a significant decreasing trend for PFOA after the change point.…”

Section: Pfoa (C8 Pfca)mentioning

confidence: 99%

“…Nine of these twelve datasets (75%), all in Europe, had a significant change point and most change points were detected between 1998 and 2003. The earliest change point for PFOS was in 1988 for pooled breast milk samples from primiparous women in Stockholm [137], where the trend went from significantly increasing (pre 1988) to significantly decreasing (post 1988). Visual inspection of the data suggested a levelling off of concentrations between 1988 and 2000 before a stronger decline occurred.…”

Section: Pfos Change Point Analysismentioning

confidence: 99%

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What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

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163

122

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Background: There is a concern that continued emissions of man-made per-and polyfluoroalkyl substances (PFASs) may cause environmental and human health effects. Now widespread in human populations and in the environment, several PFASs are also present in remote regions of the world, but the environmental transport and fate of PFASs are not well understood. Phasing out the manufacture of some types of PFASs started in 2000 and further regulatory and voluntary actions have followed. The objective of this review is to understand the effects of these actions on global scale PFAS concentrations.Methods: Searches for primary research studies reporting on temporal variations of PFAS concentrations were performed in bibliographic databases, on the internet, through stakeholder contacts and in review bibliographies. No time, document type, language or geographical constraints were applied in the searches. Relevant subjects included human and environmental samples. Two authors screened all retrieved articles. Dual screening of 10% of the articles was performed at title/abstract and full-text levels by all authors. Kappa tests were used to test consistency. Relevant articles were critically appraised by four reviewers, with double checking of 20% of the articles by a second reviewer. Meta-analysis of included temporal trends was considered but judged to not be appropriate. The trends were therefore discussed in a narrative synthesis.

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Section: Pfos Change Point Analysismentioning

confidence: 54%

Section: Pfoa (C8 Pfca)mentioning

confidence: 99%

Section: Pfos Change Point Analysismentioning

confidence: 99%

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What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

Self Cite

163

122

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“…PFHxS have been detected in human umbilical blood, serum and breast milk (Kärrman et al, 2007, Monroy et al, 2008, Sundstrom et al, 2011, Glynn et al, 2012. Concentrations of PFHxS found in breast milk ranges from 0.04 ng/mL to 0.1 ng/mL (So et al, 2006, Kärrman et al, 2010.…”

Section: Introductionmentioning

confidence: 99%

A single neonatal exposure to perfluorohexane sulfonate (PFHxS) affects the levels of important neuroproteins in the developing mouse brain

Lee

Viberg

2013

NeuroToxicology

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A single neonatal exposure to perfluorohexane sulfonate (PFHxS) affects the levels of important neuroproteins in the developing mouse brain. , 37: 190-196 Neurotoxicology AbstractPerfluorohexane sulfonate (PFHxS) is an industrial chemical and belongs to the group of perfluorinated compounds (PFCs). It has recently been shown to cause developmental neurobehavioral defects in mammals. These compounds are commonly used in products such as surfactant and protective coating due to their ability to repel water-and oil stains. PFCs are globally found in the environment as well as in human umbilical cord blood, serum and breast milk. In a previous study on other well-known PFCs i.e. PFOS and PFOA, it was shown that neonatal exposure caused altered neuroprotein levels in the hippocampus and cerebral cortex in neonatal male mice. The present study show that neonatal exposure to PFHxS, during the peak of the brain growth spurt, can alter neuroprotein levels e.g. CaMKII, GAP-43, synaptophysin and tau, which are essential for normal brain development in mice. This was measured for both males and females, in hippocampus and cerebral cortex. The results suggest that PFHxS may act as a developmental neurotoxicant and the effects are similar to that of PFOS and PFOA, but also to other substances such as PCBs, PBDEs and Bisphenol A.

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“…Due to the extraordinary stability of the carbon-fluorine bond, these compounds are resistant to chemical, biological and thermal degradation. Therefore, PFAAs have been found in environments and accumulate in the bodies of humans and wildlife (Giesy and Kannan, 2002;Sundström et al, 2011;Raymer et al, 2012;Houde et al, 2006). A number of studies have demonstrated the adverse effects of PFAAs on experimental animals, mostly of PFOA and PFOS (Lau et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Cellular target recognition of perfluoroalkyl acids: In vitro evaluation of inhibitory effects on lysine decarboxylase

Wang

Yang

et al. 2014

Science of The Total Environment

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A temporal trend study (1972–2008) of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in pooled human milk samples from Stockholm, Sweden

Cited by 137 publications

References 27 publications

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

A single neonatal exposure to perfluorohexane sulfonate (PFHxS) affects the levels of important neuroproteins in the developing mouse brain

Cellular target recognition of perfluoroalkyl acids: In vitro evaluation of inhibitory effects on lysine decarboxylase

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