A targeted biocompatible organic nanoprobe for photoacoustic and near-infrared-II fluorescence imaging in living mice

Xie, Xinhui; Hu, Yili; Zhang, Chao; Song, Jialei; Zhuang, Suyang; Wang, Yuntao

doi:10.1039/c8ra08163h

Cited by 24 publications

(20 citation statements)

References 49 publications

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“…The IR1061 dye a commercial dye with high NIR-II (1064 nm) absorbance and low fluorescence quantum yield, and holds promise as a NIR-II photothermal agent but the hydrophobicity of IR1061 limits its use in biomedical applications. [31][32][33] In order to overcome this limitation, further modifications of the IR1061 are required.…”

Section: Introductionmentioning

confidence: 99%

<p>Paclitaxel/IR1061-Co-Loaded Protein Nanoparticle for Tumor-Targeted and pH/NIR-II-Triggered Synergistic Photothermal-Chemotherapy</p>

Li¹,

Qing²,

Li³

et al. 2020

IJN

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The aim of this study was to develop an "all-in-one" nanoplatform that integrates at the second near-infrared (NIR-II) region dye IR1061 and anticancer drug paclitaxel (PTX) into an apoferritin (AFN) nanocage (IR-AFN@PTX). Simultaneously, folic acid (FA), tumor target molecule, was conjugated onto IR-AFN@PTX to be IR-AFN@PTX-FA for tumortargeted and pH/NIR-II-triggered synergistic photothermal-chemotherapy. Methods: IR1061 was firstly reacted with PEG and then conjugated with AFN to be IR-AFN. Then, FA was conjugated onto the surface of IR-AFN to be IR-AFN-FA. At last, PTX was incorporated into IR-AFN-FA to fabricate a nanoplatform IR-AFN@PTX-FA. The NIR-II photothermal properties and pH/NIR-II triggered drug release were evaluated. The ability of IR-AFN@PTX-FA to target tumors was estimated using optical bioluminescence. In vitro and in vivo synergistic therapeutic effects of pH/NIR-II-triggered and tumor-targeted photothermal-chemotherapy were investigated in 4T1 tumor model. Results: IR-AFN@PTX-FA showed excellent water solubility and physiological stability, which significantly enhanced the solubility of both IR1061 and PTX. After 5 min of laser irradiation at 1064 nm, IR-AFN@PTX-FA exhibited an effective photothermal effect compared with laser irradiation at 808 nm, even when blocked with 0.6 cm thick chicken breast. Cellular uptake experiments showed IR-AFN@PTX-FA utilized clathrin-mediated and caveolae-mediated endocytosis pathways to enter 4T1 cells, and was then delivered by the endosome to the lysosome. NIR-II laser irradiation and pH could synergistically trigger PTX release, inducing significant tumor inhibition in vitro and in vivo. Conclusion: As a novel "all-in-one" nanoplatform, IR-AFN@PTX-FA was found to selectively target tumors and showed very efficient NIR-II photothermal effects and pH/NIR-II triggered drug release effects, showing a remarkable, synergistic photothermal-chemotherapy effect.

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Section: Introductionmentioning

confidence: 99%

<p>Paclitaxel/IR1061-Co-Loaded Protein Nanoparticle for Tumor-Targeted and pH/NIR-II-Triggered Synergistic Photothermal-Chemotherapy</p>

Li¹,

Qing²,

Li³

et al. 2020

IJN

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“…Despite the superiorities mentioned earlier, the development of organic molecular dyes is restricted by their susceptibility to photobleaching and diffusion and their water-immiscibility. To address these limitations, Xie and colleagues developed a targeted biocompatible organic nanoplatform [IR-PEG-folic acid (FA)] through self-assembly of elemental components in the phosphatebuffered saline (PBS) [58]. The IR-PEG-FA nanoplatform, composed of a hydrophobic organic dye IR-1061 and a hydrophilic PEG chain with an FA-targeting group (Figure 4F), exhibited excellent stability, strong NIR absorption and NIR-II emission, low cytotoxicity, and high metabolic activity, showing significantly enhanced signal contrast and brightness in PAI and NIR-II fluorescence imaging.…”

Section: Trends Trends In In Chemistry Chemistrymentioning

confidence: 99%

Development of Second Near-Infrared Photoacoustic Imaging Agents

Zhang¹,

Ning²,

Zeng³

et al. 2021

Trends in Chemistry

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“…More sophisticatedly, Xie et al demonstrated a multi-modal contrast agent after the judicious chemical modification of IR-1061 dye [101]. As depicted in Figure 19, the agent not only exhibited NIR-II imaging properties due to the commercial NIR dye (pink), but also was biocompatible due to the PEG moiety (blue) and was functionalized with a cancer-targeting folic acid moiety (orange).…”

Section: Organic Semiconducting Materials For Near-infrared Imagingmentioning

confidence: 99%

Recent Progress on Near-Infrared Photoacoustic Imaging: Imaging Modality and Organic Semiconducting Agents

et al. 2019

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Over the past few decades, the photoacoustic (PA) effect has been widely investigated, opening up diverse applications, such as photoacoustic spectroscopy, estimation of chemical energies, or point-of-care detection. Notably, photoacoustic imaging (PAI) has also been developed and has recently received considerable attention in bio-related or clinical imaging fields, as it now facilitates an imaging platform in the near-infrared (NIR) region by taking advantage of the significant advancement of exogenous imaging agents. The NIR PAI platform now paves the way for high-resolution, deep-tissue imaging, which is imperative for contemporary theragnosis, a combination of precise diagnosis and well-timed therapy. This review reports the recent progress on NIR PAI modality, as well as semiconducting contrast agents, and outlines the trend in current NIR imaging and provides further direction for the prospective development of PAI systems.

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A targeted biocompatible organic nanoprobe for photoacoustic and near-infrared-II fluorescence imaging in living mice

Abstract: We developed a targeted organic nanoprobe for both photoacoustic imaging and near-infrared-II fluorescence imaging in living mice.

Cited by 24 publications

References 49 publications

<p>Paclitaxel/IR1061-Co-Loaded Protein Nanoparticle for Tumor-Targeted and pH/NIR-II-Triggered Synergistic Photothermal-Chemotherapy</p>

<p>Paclitaxel/IR1061-Co-Loaded Protein Nanoparticle for Tumor-Targeted and pH/NIR-II-Triggered Synergistic Photothermal-Chemotherapy</p>

Development of Second Near-Infrared Photoacoustic Imaging Agents

Recent Progress on Near-Infrared Photoacoustic Imaging: Imaging Modality and Organic Semiconducting Agents

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