A tale of two Hippo pathway modules

Abstract

The Hippo pathway is an evolutionarily conserved pathway with crucial roles in development, organ size control, tissue homeostasis and cancer. Over two decades of research have elucidated the core Hippo pathway kinase cascade, but its precise organization has not been fully understood. In this issue of The EMBO Journal, Qi et al (2023) report a new model of two modules for the Hippo kinase cascade, providing new insights into this long‐standing question.