A szexuális funkciózavar és a metabolikus szindróma                     kapcsolata

Zsoldos, Márta; Pajor, Attila; Pusztafalvi, Henriette

doi:10.1556/650.2019.31235

Cited by 11 publications

(4 citation statements)

References 45 publications

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“…For example, GO terms included “regulation of primary metabolic process” “regulation of cellular metabolic process” and “cellular response to stress”. Literature verification showed that the above pathways were related to the pathological mechanism of DMED ( Matfin et al, 2005 ; Zsoldos et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Identification of miRNA Signature Associated With Erectile Dysfunction in Type 2 Diabetes Mellitus by Support Vector Machine-Recursive Feature Elimination

Zhao

Zhong

et al. 2021

Front. Genet.

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Diabetic mellitus erectile dysfunction (DMED) is one of the most common complications of diabetes mellitus (DM), which seriously affects the self-esteem and quality of life of diabetics. MicroRNAs (miRNAs) are endogenous non-coding RNAs whose expression levels can affect multiple cellular processes. Many pieces of studies have demonstrated that miRNA plays a role in the occurrence and development of DMED. However, the exact mechanism of this process is unclear. Hence, we apply miRNA sequencing from blood samples of 10 DMED patients and 10 DM controls to study the mechanisms of miRNA interactions in DMED patients. Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR-342–3p), called DMEDSig-4. Subsequently, we correlated DMEDSig-4 with clinical factors and further verified the ability of these miRNAs to classify samples. Finally, we functionally verified the relationship between DMEDSig-4 and DMED by pathway enrichment analysis of miRNA and its target genes. In brief, our study found four key miRNAs, which may be the key influencing factors of DMED. Meanwhile, the DMEDSig-4 could help in the development of new therapies for DMED.

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Section: Resultsmentioning

confidence: 99%

Identification of miRNA Signature Associated With Erectile Dysfunction in Type 2 Diabetes Mellitus by Support Vector Machine-Recursive Feature Elimination

Zhao

Zhong

et al. 2021

Front. Genet.

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“…Erectile dysfunction (ED), defined as the inability to attain and/or maintain an erection satisfactorily during sexual acts, affects about 50% of men in the United States and approximately 322 million men worldwide [196]. The pathological alterations underlying ED have many of the same risk factors as MetS, including hypertension, dyslipidemia, physical inactivity, and visceral obesity [197]. NAFLD is recognized as the hepatic manifestation of MetS, therefore several studies evaluated its possible correlation with ED, identifying NAFLD as a risk factor for the presence of ED [198].…”

Section: Resultsmentioning

confidence: 99%

“…EndocrinopathiesPolycystic ovarian syndromeHypothyroidismObesity and IR are common risk factors for both PCOS and NAFLD [207,208,209,210]. The prevalence of NAFLD is higher in patients with hypothyroidism; furthermore, low thyroid function seems to worsen the progression of liver damage, while replacement therapy may improve liver function [187,188,189,194,195,196,197]. Emerging LinkagesOsteoporosisNAFLD is associated with a 2.5-fold risk of osteoporotic fractures [122,124,125].…”

Section: Table A1mentioning

confidence: 99%

NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

Rosato

Masarone

Dallio

et al. 2019

IJERPH

100

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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and its incidence is definitely increasing. NAFLD is a metabolic disease with extensive multi-organ involvement, whose extra-hepatic manifestations include type 2 diabetes mellitus, cardiovascular disease, obstructive sleep apnea, chronic kidney disease, osteoporosis, and polycystic ovarian syndrome. Recently, further evidence has given attention to pathological correlations not strictly related to metabolic disease, also incorporating in this broad spectrum of systemic involvement hypothyroidism, psoriasis, male sexual dysfunction, periodontitis, and urolithiasis. The most common cause of mortality in NAFLD is represented by cardiovascular disease, followed by liver-related complications. Therefore, clinicians should learn to screen and initiate treatment for these extra-hepatic manifestations, in order to provide appropriate multidisciplinary assessments and rigorous surveillance. This review evaluates the current evidence regarding extra-hepatic associations of NAFLD, focusing on the pathogenic hypothesis and the clinical implications.

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“…One of the limitations of our study is the absence of data regarding VLS stages. Some studies showed that advanced age, postmenopausal state, low educational status, singleness, physical and psychological health problems, negative sexual experiences were predictors of sexual dysfunction [27][28][29]. There is a strong relationship between sexual satisfaction and menopausal state [27].…”

Section: Limitationsmentioning

confidence: 99%

The effect of vulvar lichen sclerosus on quality of life and sexual functioning

Helvacıoğlu¹,

Topkarcı²,

Helvacıoğlu³

et al. 2021

Journal of Surgery and Medicine

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Background/Aim: Vulvar lichen sclerosus (VLS) is a chronic inflammatory condition that has the potential to cause sexual dysfunction and reduction in patients' life quality. We aimed to evaluate the quality of life and sexual function in female patients with VLS. Methods: This prospective case-control study was conducted with women who presented to the gynecology clinic with a biopsy-proven diagnosis of VLS or for routine gynecological check-ups between June 2017-January 2018. The patients were grouped according to the presence or absence of VLS. Effects of VLS on quality of life and sexual functions were analyzed with the Dermatology Life Quality Index (DLQI) and Female Sexual Function Index (FSFI) questionnaires. Results: A total of 86 women were included in this study. Thirty-seven VLS patients were compared with 49 patients without VLS. The total DLQI scores of the VLS and control groups were 6.14 (6.87) and 1.92 (2.41), respectively (P=0.001), and the total FSFI scores, 15.42 and 24.22, respectively (P<0.001). Subgroup analyses revealed that the two groups significantly differed in terms of sexual desire, arousal, orgasm, satisfaction, and pain (P<0.001), but not in terms of lubrication (P=0.741). Conclusion:Vulvar lichen sclerosus negatively affects the quality of life and sexual function. Questionnaires such as DLQI and FSFI are useful tools for the assessment of sexual function and quality of life in these patients. Since these patients may be hesitant to report their sexual problems, healthcare professionals should interrogate them in this regard during the early stages of management.

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A szexuális funkciózavar és a metabolikus szindróma kapcsolata

Cited by 11 publications

References 45 publications

Identification of miRNA Signature Associated With Erectile Dysfunction in Type 2 Diabetes Mellitus by Support Vector Machine-Recursive Feature Elimination

Identification of miRNA Signature Associated With Erectile Dysfunction in Type 2 Diabetes Mellitus by Support Vector Machine-Recursive Feature Elimination

NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

The effect of vulvar lichen sclerosus on quality of life and sexual functioning

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