A systemic biokinetic model for polonium

Leggett, R. W.; Eckerman, K.F.

doi:10.1016/s0048-9697(00)00858-5

Cited by 59 publications

(68 citation statements)

References 27 publications

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“…A comprehensive approach to estimating doses received by Rocketdyne employees has been described (5). Briefly, lifetime occupational doses from all places of employment were sought, and radiation doses from intakes of 14 different radionuclides were calculated for 16 organs or tissues using current biokinetic models of the International Commission on Radiation Protection (ICRP) or 41,169 a 3.6% of the non-radiation workers had been monitored elsewhere.…”

Section: Dose Reconstructionmentioning

confidence: 99%

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Updated Mortality Analysis of Radiation Workers at Rocketdyne (Atomics International), 1948–2008

et al. 2011

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Updated analyses of mortality data are presented on 46,970 workers employed 1948-1999 at Rocketdyne (Atomics International). Overall, 5,801 workers were involved in radiation activities, including 2,232 who were monitored for intakes of radionuclides, and 41,169 workers were engaged in rocket testing or other non-radiation activities. The worker population is unique in that lifetime occupational doses from all places of employment were sought, updated and incorporated into the analyses. Further, radiation doses from intakes of 14 different radionuclides were calculated for 16 organs or tissues using biokinetic models of the International Commission on Radiation Protection (ICRP). Because only negligible exposures were received by the 247 workers monitored for radiation activities after 1999, the mean dose from external radiation remained essentially the same at 13.5 mSv (maximum 1 Sv) as reported previously, as did the mean lung dose from external and internal radiation combined at 19.0 mSv (maximum 3.6 Sv). An additional 9 years of follow-up, from December 31,1999 through 2008, increased the person-years of observation for the radiation workers by 21.7% to 196,674 (mean 33.9 years) and the number of cancer deaths by 50% to 684. Analyses included external comparisons with the general population and the computation of standardized mortality ratios (SMRs) and internal comparisons using proportional hazards models and the computation of relative risks (RRs). A low SMR for all causes of death (SMR 0.82; 95% CI 0.78-0.85) continued to indicate that the Rocketdyne radiation workers were healthier than the general population and were less likely to die. The SMRs for all cancers taken together (SMR 0.88; 95% CI 0.81-0.95), lung cancer (SMR 0.87; 95% CI 0.76-1.00) and leukemia other than chronic lymphocytic leukemia (CLL) (SMR 1.04; 95% 0.67-1.53) were not significantly elevated. Cox regression analyses revealed no significant dose-response trends for any cancer. For all cancers excluding leukemia, the RR at 100 mSv was estimated as 0.98 (95% CI 0.82-1.17), and for all leukemia other than CLL it was 1.06 (95% CI 0.50-2.23).

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Section: Dose Reconstructionmentioning

confidence: 99%

“…updated versions of those models proposed for use in upcoming ICRP documents (2,5,6). The radionuclides with documented intakes included isotopes of uranium, plutonium, americium, calcium, cesium, cerium, zirconium, thorium, polonium, promethium, iodine, zinc, strontium and hydrogen (tritium).…”

mentioning

confidence: 99%

Updated Mortality Analysis of Radiation Workers at Rocketdyne (Atomics International), 1948–2008

et al. 2011

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“…The systemic biokinetics of polonium has been studied in accidentally exposed persons, in controlled experiments involving a few unhealthy human subjects, and in several types of laboratory animals including non-human primates and dogs (ICRP 1993, Leggett andEckerman 2001). The urinary excretion rate of polonium appears to be species dependent, resulting in a species-dependent removal half-time from the body.…”

Section: Poloniummentioning

confidence: 99%

Uncertainties in Cancer Risk Coefficients for Environmental Exposure to Radionuclides. An Uncertainty Analysis for Risk Coefficients Reported in Federal Guidance Report No. 13

Pawel¹,

Leggett²,

Eckerman³

et al. 2007

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“…In addition, various authors had attempted to identify chelating agents of high efficacy, some with variable degrees of success [6][7][8][9][10][11]. Lengthy and comprehensive reviews devoted to polonium-including a report on its biokinetics-and articles specifically about 210 Po were generally directed toward specialists in health physics [12][13][14][15]. Few of these articles appeared in the medical literature and public health officials had a limited understanding about the toxicity of polonium.…”

Section: Isotope Identificationmentioning

confidence: 99%

The Polonium-210 Public Health Assessment: The Need for Medical Toxicology Expertise in Radiation Terrorism Events

Nemhauser

2010

J. Med. Toxicol.

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A systemic biokinetic model for polonium

Cited by 59 publications

References 27 publications

Updated Mortality Analysis of Radiation Workers at Rocketdyne (Atomics International), 1948–2008

Updated Mortality Analysis of Radiation Workers at Rocketdyne (Atomics International), 1948–2008

Uncertainties in Cancer Risk Coefficients for Environmental Exposure to Radionuclides. An Uncertainty Analysis for Risk Coefficients Reported in Federal Guidance Report No. 13

The Polonium-210 Public Health Assessment: The Need for Medical Toxicology Expertise in Radiation Terrorism Events

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