Uncertainties in Cancer Risk Coefficients for Environmental Exposure to Radionuclides. An Uncertainty Analysis for Risk Coefficients Reported in Federal Guidance Report No. 13

Pawel, David J.; Leggett, Richard W.; Eckerman, K.F.; Nelson, Christopher B.

doi:10.2172/932607

Cited by 9 publications

(10 citation statements)

References 54 publications

(63 reference statements)

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“…(321) The following categorisation of the main types of information used to develop biokinetic models and assess model reliability is taken from a paper by Leggett (2001). Investigations of the reliability of many of the biokinetic models that have been used in ICRP reports can be found in the following papers and reports: Apostoaei et al (1998); Leggett (2001); Leggett et al (1998Leggett et al ( , 2007Leggett et al ( , 2008; Harrison et al (2001Harrison et al ( , 2002; Bolch et al (2001Bolch et al ( , 2003; Skrable et al (2002); Likhtarev et al (2003); Apostoaei and Miller (2004); Sa´nchez (2007); Pawel et al (2007); and NCRP (2010).…”

Section: Uncertainties In Biokinetic Modelsmentioning

confidence: 99%

ICRP Publication 130: Occupational Intakes of Radionuclides: Part 1

Paquet¹,

et al. 2015

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This report is the first in a series of reports replacing Publications 30 and 68 to provide revised dose coefficients for occupational intakes of radionuclides by inhalation and ingestion. The revised dose coefficients have been calculated using the Human Alimentary Tract Model (Publication 100) and a revision of the Human Respiratory Tract Model (Publication 66) that takes account of more recent data. In addition, information is provided on absorption into blood following inhalation and ingestion of different chemical forms of elements and their radioisotopes. In selected cases, it is judged that the data are sufficient to make material-specific recommendations. Revisions have been made to many of the models that describe the systemic biokinetics of radionuclides absorbed into blood, making them more physiologically realistic representations of uptake and retention in organs and tissues, and excretion. The reports in this series provide data for the interpretation of bioassay measurements as well as dose coefficients, replacing Publications 54 and 78. In assessing bioassay data such as measurements of whole-body or organ content, or urinary excretion, assumptions have to be made about the exposure scenario, including the pattern and mode of radionuclide intake, physical and chemical characteristics of the material involved, and the elapsed time between the exposure(s) and measurement. This report provides some guidance on monitoring programmes and data interpretation.

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Section: Uncertainties In Biokinetic Modelsmentioning

confidence: 99%

ICRP Publication 130: Occupational Intakes of Radionuclides: Part 1

Paquet¹,

et al. 2015

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“…According to Pawel et al (2007), ''most risk coefficients for inhalation of radionuclides are determined within a factor of five or less by current information.'' This conclusion applies specifically to the risk coefficients for inhaled HTO v by the adult worker and resident (based on the assignment of the mortality risk coefficient for inhaled 3 H vapor to the narrowest of the relatively broad, semi-quantitative ''uncertainty categories'' used to address uncertainty in the risk coefficient for this radionuclide and exposure mode).…”

Section: Sensitivity Of Risk Assessment Results To Parameter Uncertaimentioning

confidence: 99%

Determination and Maintenance of de Minimis Risk for Migration of Residual Tritium (3H) From the 1969 Project Rulison Nuclear Test to Nearby Hydraulically Fractured Natural Gas Wells

Daniels

Chapman

2013

Health Physics

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The Project Rulison underground nuclear test was a proof-of-concept experiment that was conducted under the Plowshare Program in 1969 in the Williams Fork Formation of the Piceance Basin in west-central Colorado. Today, commercial production of natural gas is possible from low permeability, natural gas bearing formations like that of the Williams Fork Formation using modern hydraulic fracturing techniques. With natural gas exploration and production active in the Project Rulison area, this human health risk assessment was performed in order to add a human health perspective for site stewardship. Tritium (H) is the radionuclide of concern with respect to potential induced migration from the test cavity leading to subsequent exposure during gas-flaring activities. This analysis assumes gas flaring would occur for up to 30 d and produce atmospheric H activity concentrations either as low as 2.2 × 10 Bq m (6 × 10 pCi m) from the minimum detectable activity concentration in produced water or as high as 20.7 Bq m (560 pCi m), which equals the highest atmospheric measurement reported during gas-flaring operations conducted at the time of Project Rulison. The lifetime morbidity (fatal and nonfatal) cancer risks calculated for adults (residents and workers) and children (residents) from inhalation and dermal exposures to such activity concentrations are all below 1 × 10 and considered de minimis. The implications for monitoring production water for conforming health-protective, risk-based action levels also are examined.

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“…, and are the excess lifetime cancer risk, the annual intake of radionuclide (Bq), the average lifespan 72 yr. (life expectancy of a male and a female are 70.6 years and 73.5 years, respectively in Bangladesh [33]), and the mortality cancer risk coefficient (Bq -1 ), respectively. The values of mortality cancer risk coefficients are 9.56 × 10 −9 Bq -1 for 226 Ra, 2.45 × 10 −9 Bq -1 for 232 Th, and 5.89 × 10 −10 Bq -1 for 40 K [12,31]. The acceptable ELCR limit is 10 −3 for radiological risk in general [32,34].…”

Section: Excess Lifetime Cancer Risk (Elcr)mentioning

confidence: 94%

“…One of the reasons is the effect of radiation on the biological cells, which contributes to a greater extent to increasing cancer incidence. An effort was made to assess the excess lifetime cancer risk due to the ingestion of marine fish and crustaceans by the procedure proposed by the United States Environmental Protection Agency (USEPA) [31]. The following equation was used to calculate the excess lifetime cancer risk [12,32]:…”

Section: Excess Lifetime Cancer Risk (Elcr)mentioning

confidence: 99%

Assessment of the Levels of Pollution and of Their Risks by Radioactivity and Trace Metals on Marine Edible Fish and Crustaceans at the Bay of Bengal (Chattogram, Bangladesh)

et al. 2021

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Marine environmental pollution is a longstanding global problem and has a particular impact on the Bay of Bengal. Effluent from different sources directly enters rivers of the region and eventually flows into the Bay of Bengal. This effluent may contain radioactive materials and trace metals and pose a serious threat to the coastal environment, in addition to aquatic ecosystems. Using gamma spectrometry and atomic absorption spectrometry, a comprehensive study was carried out on the radioactivity (226Ra, 232Th, 40K, and 137Cs) and trace metal (Cd, Pb, Zn, Cu, Ni, Fe, Mn, and Cr) concentrations, respectively, in fish and crustacean species collected from the coastal belt of the Bay of Bengal (Chattogram, Bangladesh). The analysis showed a noticeable increment in the levels of different radioactive pollutants in the marine samples, although the consumption of the studied fish and crustacean species should be considered safe for human health. Anthropogenic radionuclide (137Cs) was not detected in any sample. Furthermore, the metal concentrations of a small number of trace elements (Pb, Cd, Cr) were found to be higher in most of the samples, which indicates aquatic fauna are subject to pollution. The estimated daily intake (EDI), target hazard quotient (THQ), hazard index (HI), and target cancer risk (TR) were calculated and compared with the permissible safety limits. It was found that consuming the seafood from the Bay of Bengal may cause adverse health impacts if consumption and/or means of pollution are not controlled.

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Uncertainties in Cancer Risk Coefficients for Environmental Exposure to Radionuclides. An Uncertainty Analysis for Risk Coefficients Reported in Federal Guidance Report No. 13

Cited by 9 publications

References 54 publications

ICRP Publication 130: Occupational Intakes of Radionuclides: Part 1

ICRP Publication 130: Occupational Intakes of Radionuclides: Part 1

Determination and Maintenance of de Minimis Risk for Migration of Residual Tritium (3H) From the 1969 Project Rulison Nuclear Test to Nearby Hydraulically Fractured Natural Gas Wells

Assessment of the Levels of Pollution and of Their Risks by Radioactivity and Trace Metals on Marine Edible Fish and Crustaceans at the Bay of Bengal (Chattogram, Bangladesh)

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