A systematic review on the cardiovascular pharmacology of Emblica officinalis Gaertn.

Hashem-Dabaghian, Fataneh; Ziaee, Mojtaba; Ghaffari, Samad; Nabati, Farzaneh; Kianbakht, S

doi:10.15171/jcvtr.2018.20

Cited by 30 publications

(20 citation statements)

References 34 publications

(11 reference statements)

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“…Components of CP— Amla, Neelkamal, Punarnawa, Pushkarmul, Kachur, Vasa, Bala, Sarivan, Pithawan, Barikateri and Gokshur —are well-recognized in their ability to rejuvenate and restore the cardiovascular system functions [92,93]. Amla has shown antiatherogenic, anticoagulant, hypolipidemic, antihypertensive, antioxidant, antiplatelet, and vasodilatory effects, as well as lipid deposition inhibitory properties [125]. In rat models, Punarnawa increased the reduced level of glutathione (GSH), superoxide dismutase (SOD) catalase (CAT) and decreased the elevated level of malondialdehyde (MDA) in cardiac tissue [126].…”

Section: Health Benefitsmentioning

confidence: 99%

Chyawanprash: A Traditional Indian Bioactive Health Supplement

et al. 2019

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Chyawanprash (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging. Chyawanprash is formulated by processing around 50 medicinal herbs and their extracts, including the prime ingredient, Amla (Indian gooseberry), which is the world’s richest source of vitamin C. Chyawanprash preparation involves preparing a decoction of herbs, followed by dried extract preparation, subsequent mixture with honey, and addition of aromatic herb powders (namely clove, cardamom, and cinnamon) as standard. The finished product has a fruit jam-like consistency, and a sweet, sour, and spicy flavor. Scientific exploration of CP is warranted to understand its therapeutic efficacy. Scattered information exploring the therapeutic potential of CP is available, and there is a need to assemble it. Thus, an effort was made to compile the scattered information from ancient Ayurvedic texts and treatises, along with ethnobotanical, ethnopharmacological, and scientifically validated literature, that highlight the role of CP in therapeutics. Citations relevant to the topic were screened.

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Section: Health Benefitsmentioning

confidence: 99%

Chyawanprash: A Traditional Indian Bioactive Health Supplement

et al. 2019

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“…EO is rich in phenols (gallic acids, methyl gallate, ellagic acid, and trigalloyl glucose) and flavonoids (quercetin and kaempferol) [ 13 ]. Previous studies suggest that taking polyphenol-rich foods can have good effects on cardiovascular diseases including hypertension and endothelial and platelet functions [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a systematic review of Hashem-Dabaghian et al in 2018, the cardiovascular effects of this plant had been investigated [ 13 ]. According to the results of this review, EO has antiatherogenic, antihypertensive, anti-inflammatory, antioxidant, antiplatelet, vasodilator, and lipid deposition inhibitory effects.…”

Section: Introductionmentioning

confidence: 99%

A Randomized, Triple‐Blind, Placebo‐Controlled, Add‐On Clinical Trial to Evaluate the Efficacy of Emblica officinalis in Uncontrolled Hypertension

Ghaffari

Navabzadeh

Ziaee

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Introduction. Emblica officinalis (EO) has some cardiovascular effects, and there are some animal studies that show its antihypertensive effect. This study was conducted to determine the effect of combination of EO with standard therapy on the systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with uncontrolled hypertension. Materials and Methods. This was a randomized, triple-blind, placebo-controlled, 8-week study. Ninety-two patients with uncontrolled hypertension despite taking hypotensive drugs were randomly assigned into two groups to take EO (500 mg/TDS after meal) or placebo in combination with standard antihypertensive drugs. After 2, 4, 6, and 8 weeks of intervention, SBP and DBP and heart rate (HR) were measured. Data were analyzed by SPSS software using repeated measures ANOVA. Results. Eighty-one patients (41 in the drug group and 40 in the placebo group) completed the study for 8 weeks and were analyzed. The mean ± standard deviation of age was 53.64 ± 10.01 years. SBP decreased as 15.6 ± 8.23% in the EO group and 6.3 ± 7.49% in the placebo group ( P < 0.001 ). DBP decreased as 12.3 ± 7.87% and 3.88 ± 7.98%, respectively ( P < 0.001 ). Time effect was not significant, but the group effect was significant (F = 13.875, P = 0.001 for systolic BP and F = 18.948, P < 0.001 for diastolic BP). No side effects were reported during the study. Conclusion. Eight-week combination therapy of EO with standard antihypertensive drugs significantly reduced the SBP and DBP more than placebo in patients with uncontrolled hypertension.

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“…Ingredients of CP such as Phyllanthus Emblica, Boerhavia diffusa, Inula racemose, Curcuma zedoaria, Sida cordifolia, Solanum virginianum and Tribulus Terrestris are well-known to revitalize and reinstate the functions of the cardiovascular system. Amlalki, the prime drug of CP, exhibits hypolipidemic, anticoagulant, antiatherogenic, antiplatelet, antihypertensive and vasodilatory effects (Hashem-Dabaghian et al, 2018).…”

Section: A Possible Role Of Chyawanprash In Management Of Covid-19mentioning

confidence: 99%

Chyavanprash: Choice of Drug for immunity boosting and health supplements during COVID -19 pandemic

Rathi

Ade

et al. 2020

ijrps

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Chyavanprash a known Ayurvedic formulation formulated by sage Chyavan to impart youth, charm, strength & prolonged life. It is very much valued for possessing numerous health benefits with respect to the preventive, curative and promotive aspects of health. Chyavanprash can be consumed throughout the year. Several scientific evidences support its wholesome and safe healthy tonic status that is favorable for all age groups and genders alike. In modern days, it has gained mammoth popularity throughout the world. CP is prepared with Amalaki (Emblica officinalis) as a prime drug with other nutrient rich herbs help to preserve stamina, strength and vitality. Various pre clinical (in vivo & in vitro), Experimental, Analytical and clinical studies conducted on CP and its individual components revealed its various pharmacological activities most of which are suggestive of immunity enhancer and health supplements. Hence an attempt is made in the present paper to find out and explore the scientific evidences based on therapeutic potential of CP with respect to immunity and health supplements and make evidences available to the common people to combat the COVID-19 menace effectively.

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A systematic review on the cardiovascular pharmacology of Emblica officinalis Gaertn.

Cited by 30 publications

References 34 publications

Chyawanprash: A Traditional Indian Bioactive Health Supplement

Chyawanprash: A Traditional Indian Bioactive Health Supplement

A Randomized, Triple‐Blind, Placebo‐Controlled, Add‐On Clinical Trial to Evaluate the Efficacy of Emblica officinalis in Uncontrolled Hypertension

Chyavanprash: Choice of Drug for immunity boosting and health supplements during COVID -19 pandemic

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