A systematic review of the association between obesity and asthma in children

Liu, Pei Ching; Kieckhefer, Gail M.; Gau, Bih‐Shya

doi:10.1111/jan.12129

Cited by 37 publications

(37 citation statements)

References 84 publications

(194 reference statements)

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“…Obesity is more common among asthmatic children, [27][28][29] and recent data suggest that obesity might also play a role in the development of AD. [30][31][32] However, these studies were primarily in school-aged children and used body mass index (BMI) as a proxy for adiposity.…”

mentioning

confidence: 98%

Neonatal adiposity increases the risk of atopic dermatitis during the first year of life

O’Donovan

Hourihane

Murray

et al. 2016

Journal of Allergy and Clinical Immunology

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mentioning

confidence: 98%

Neonatal adiposity increases the risk of atopic dermatitis during the first year of life

O’Donovan

Hourihane

Murray

et al. 2016

Journal of Allergy and Clinical Immunology

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“…Obesity has become an acute focal point of research, as it is a strong risk factor for various diseases. These include CVD, diabetes, asthma, orthopaedic diseases and some forms of cancers (3)(4)(5)(6)(7) , not to mention the social stigma and low self-esteem that obese individuals may suffer (3) .…”

Section: Overweight and Obesitymentioning

confidence: 99%

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

2016

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Obesity is a risk factor for asthma, and obese asthmatics have lower disease control and increased symptom severity. Several putative links have been proposed, including genetics, mechanical restriction of the chest and the intake of corticosteroids. The most consistent evidence, however, comes from studies of cytokines produced by the adipose tissue called adipokines. Adipokine imbalance is associated with both proinflammatory status and asthma. Although reverse causation has been proposed, it is now acknowledged that obesity precedes asthma symptoms. Nevertheless, prenatal origins of both conditions complicate the search for causality. There is a confirmed role of neuro-immune cross-talk mediating obesityinduced asthma, with leptin playing a key role in these processes. Obesity-induced asthma is now considered a distinct asthma phenotype. In fact, it is one of the most important determinants of asthma phenotypes. Two main subphenotypes have been distinguished. The first phenotype, which affects adult women, is characterised by later onset and is more likely to be non-atopic. The childhood obesity-induced asthma phenotype is characterised by primary and predominantly atopic asthma. In obesity-induced asthma, the immune responses are shifted towards T helper (Th) 1 polarisation rather than the typical atopic Th2 immunological profile. Moreover, obese asthmatics might respond differently to environmental triggers. The high cost of treatment of obesity-related asthma, and the burden it causes for the patients and their families call for urgent intervention. Phenotype-specific approaches seem to be crucial for the success of prevention and treatment.

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“…Most of the authors have found the existence of association between obesity and asthma in children as well [14][15][16][17][18]. However, this opinion is not shared by everyone.…”

mentioning

confidence: 99%

Relative Body Mass Index as a New Tool for Nutritional Status Assessment in Children and Adolescents with Bronchial Asthma

Eliseeva¹,

Геппе²,

Ignatov³

et al. 2017

Sovrem Tehnol Med

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The aim of the investigation was to estimate the possibilities of using relative body mass index (RBMI) for determining age-and gender-specific aspects of nutritional status in children and adolescents with bronchial asthma (BA) of different severity degrees.Materials and Methods. The study involved 887 children and adolescents with BA of different severities, aged 5-17 years (61-215 months), of them 655 were boys. Their body mass index (BMI) was evaluated based on the Z-score criterion and nutritional status was determined as recommended by the World Health Organization (WHO). To unify nutritional status assessment in patients of different age and gender groups, there was introduced RBMI representing the ratio of the patient's BMI to gender-and age-specific median BMI value presented in the WHO reference data.Results. Nutritional status and its relation to BA were studied in children and adolescents using two parameters: the standard nutritional status indicator based on BMI Z-scores as recommended by WHO, and a new parameter, RBMI, representing the ratio of the patient's BMI to gender-and age-specific median BMI value recommended by WHO. No significant nutritional status differences were found in the studied sample of patients with various degrees of BA severity. There was revealed a tendency to a decrease in the proportion of children with normal body weight and an increase in the proportion of overweight children as BA severity increased, χ 2 =26.82; р=0.08. Conclusion. Using RBMI for assessment of BA patients makes it possible to significantly facilitate clinical data analysis and obtain new data unavailable when standard parameters are applied.Key words: bronchial asthma; nutritional status of children; obesity in asthma; body mass index; relative body mass index.

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A systematic review of the association between obesity and asthma in children

Cited by 37 publications

References 84 publications

Neonatal adiposity increases the risk of atopic dermatitis during the first year of life

Neonatal adiposity increases the risk of atopic dermatitis during the first year of life

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

Relative Body Mass Index as a New Tool for Nutritional Status Assessment in Children and Adolescents with Bronchial Asthma

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