A Systematic Review of the Interplay Between Social Determinants and Environmental Exposures for Early-Life Outcomes

Appleton, Allison A.; Holdsworth, Elizabeth A.; Kubzansky, Laura D.

doi:10.1007/s40572-016-0099-7

Cited by 47 publications

(46 citation statements)

References 78 publications

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“…The potential long-term effects of in utero exposure to DDT/E in low- and middle-income settings where IRS is practiced, including their interaction with maternal and familial factors, such as socioeconomic status ( Appleton et al. 2016 ; Stein et al.…”

Section: Discussionmentioning

confidence: 99%

“…In our study area (Limpopo Province, South Africa), intestinal infections, influenza, and pneumonia together account for 26.2% and 23.6% of all deaths among infants under 1 y and children 1–14 y of age, respectively ( Statistics South Africa 2017 ). Moreover, early adversity factors such as poverty ( Appleton et al. 2016 ; Stein et al.…”

Section: Introductionmentioning

confidence: 99%

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Maternal Peripartum Serum DDT/E and Urinary Pyrethroid Metabolite Concentrations and Child Infections at 2 Years in the VHEMBE Birth Cohort

Huang

Eskenazi

Bornman

et al. 2018

Environ Health Perspect

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Background:Indoor residual spraying (IRS) of insecticides, conducted in low- and middle-income countries to control malaria, may result in high exposure to dichlorodiphenyltrichloroethane (DDT), its breakdown product dichlorodiphenyldichloroethylene (DDE), or pyrethroids. Animal studies suggest in utero exposure to these chemicals may increase childhood infection frequency.Objectives:We investigated associations between maternal DDT/E and pyrethroid metabolite concentration and child infection associations in an IRS setting in which susceptibility factors are common and infections are leading causes of child morbidity and mortality.Methods:Using gas chromatography–mass spectrometry, we measured serum DDT/E and urinary pyrethroid metabolite concentrations in peripartum samples from 674 women participating in the Venda Health Examination of Mother, Babies and their Environment (VHEMBE) study. Counts of persistent child fevers, otitis media, and severe sore throat between 1 and 2 y of age were ascertained from maternal interviews. Associations between DDT/E and pyrethroid metabolite concentrations and infections were estimated using zero-inflated Poisson regression. We estimated relative excess risks due to interaction (RERI) with poverty, maternal energy intake, and maternal HIV status.Results:Concentrations of DDT/E, particularly p,p′-DDE, were associated with higher rates of persistent fevers [IRR=1.21 (95% CI: 1.01, 1.46)], for a 10-fold increase in p,p′-DDE). This association was stronger among children from households below versus above the South African food poverty line [IRR=1.31 (95% CI: 1.08, 1.59) vs. IRR=0.93 (95% CI: 0.69, 1.25), respectively] and for children whose mothers had insufficient versus sufficient caloric intake during pregnancy [IRR=1.30 (95% CI: 1.07, 1.58) vs. IRR=0.96 (95% CI: 0.72, 1.28), respectively].Conclusions:In utero IRS insecticide exposure may increase childhood infection rates. This was particularly apparent among children from poorer households or whose mothers had low energy intake during pregnancy. https://doi.org/10.1289/EHP2657

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal Peripartum Serum DDT/E and Urinary Pyrethroid Metabolite Concentrations and Child Infections at 2 Years in the VHEMBE Birth Cohort

Huang

Eskenazi

Bornman

et al. 2018

Environ Health Perspect

View full text Add to dashboard Cite

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“…Since SES is both related to air pollutants17 and adverse perinatal outcomes,40 socioeconomic characteristics can act as confounders when studying the effects of air pollutants on pregnancy outcomes 41. This potential for bias likely increases with the size of the study area, since large areas are generally more socially diverse; studies in large areas allow considering a large sample size and increasing exposure contrasts, but are also more likely to suffer from confounding by SES and behaviours.…”

Section: Discussionmentioning

confidence: 99%

Is atmospheric pollution exposure during pregnancy associated with individual and contextual characteristics? A nationwide study in France

Ouidir

Lepeule

Siroux

et al. 2017

J Epidemiol Community Health

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We highlighted social inequalities in atmospheric pollutants exposure according to contextual characteristics such as urbanisation level and social deprivation and also according to individual characteristics such as education, being in a relationship and smoking status. In French urban areas, pregnant women from the most deprived neighbourhoods were those most exposed to health-threatening atmospheric pollutants.

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“…In addition, exposure to air pollution can have longer-term health effects resulting in mortality [29]. Studies have shown significant associations between exposure to particulate matter and respiratory morbidity among children [30][31][32]. A recent study indicated a biological linkage between air pollution exposure and diarrhea [2].…”

Section: Introductionmentioning

confidence: 99%

Exposure to Outdoor Particles (PM2.5) and Associated Child Morbidity and Mortality in Socially Deprived Neighborhoods of Nairobi, Kenya

et al. 2018

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Exposure to air pollution is associated with adverse health outcomes. However, the health burden related to ambient outdoor air pollution in sub-Saharan Africa remains unclear. This study examined the relationship between exposure to outdoor air pollution and child health in urban slums of Nairobi, Kenya. We conducted a semi-ecological study among children under 5 years of age from two slum areas and exposure measurements of particulate matter (PM2.5) at the village level were aligned to data from a retrospective cohort study design. We used logistic and Poisson regression models to ascertain the associations between PM2.5 exposure level and child morbidity and mortality. Compared to those in low-pollution areas (PM2.5 < 25 µg/m3), children in high-pollution areas (PM2.5 ≥ 25 µg/m3) were at significantly higher risk for morbidity in general (odds ratio (OR) = 1.25, 95% confidence interval (CI): 1.11–1.41) and, specifically, cough (OR = 1.38, 95% CI: 1.20–1.48). Exposure to high levels of pollution was associated with a high child mortality rate from all causes (IRR = 1.22, 95% CI: 1.08–1.39) and respiratory causes (IRR = 1.12, 95% CI: 0.88–1.42). The findings indicate that there are associated adverse health outcomes with air pollution in urban slums. Further research on air pollution health impact assessments in similar urban areas is required.

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A Systematic Review of the Interplay Between Social Determinants and Environmental Exposures for Early-Life Outcomes

Cited by 47 publications

References 78 publications

Maternal Peripartum Serum DDT/E and Urinary Pyrethroid Metabolite Concentrations and Child Infections at 2 Years in the VHEMBE Birth Cohort

Maternal Peripartum Serum DDT/E and Urinary Pyrethroid Metabolite Concentrations and Child Infections at 2 Years in the VHEMBE Birth Cohort

Is atmospheric pollution exposure during pregnancy associated with individual and contextual characteristics? A nationwide study in France

Exposure to Outdoor Particles (PM2.5) and Associated Child Morbidity and Mortality in Socially Deprived Neighborhoods of Nairobi, Kenya

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