A Systematic Review of the Acute Effects of Hemodialysis on Skeletal Muscle Perfusion, Metabolism, and Function

Almushayt, Shatha J.; Hussain, Samia; Wilkinson, Daniel J.; Selby, Nicholas M.

doi:10.1016/j.ekir.2019.12.012

Cited by 9 publications

(6 citation statements)

References 48 publications

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“…Another protein that is inhibited by HMB is caspase 3 ( CASP3 ) [ 10 ]. This protein has not only a positive effect on DMD [ 63 ] but also enhances some biological processes such as apoptosis and protein degradation [ 63 , 64 , 65 ] ( Figure 3 ).…”

Section: Common Pathwaysmentioning

confidence: 99%

Does β-Hydroxy-β-Methylbutyrate Have Any Potential to Support the Treatment of Duchenne Muscular Dystrophy in Humans and Animals?

Gorji,

Ostaszewski,

Urbańska

et al. 2023

Biomedicines

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Skeletal muscle is the protein reservoir of our body and an important regulator of glucose and lipid homeostasis. The dystrophin gene is the largest gene and has a key role in skeletal muscle construction and function. Mutations in the dystrophin gene cause Duchenne and Becker muscular dystrophy in humans, mice, dogs, and cats. Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular condition causing progressive muscle weakness and premature death. β-hydroxy β-methylbutyrate (HMB) prevents deleterious muscle responses under pathological conditions, including tumor and chronic steroid therapy-related muscle losses. The use of HMB as a dietary supplement allows for increasing lean weight gain; has a positive immunostimulatory effect; is associated with decreased mortality; and attenuates sarcopenia in elderly animals and individuals. This study aimed to identify some genes, metabolic pathways, and biological processes which are common for DMD and HMB based on existing literature and then discuss the consequences of that interaction.

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Section: Common Pathwaysmentioning

confidence: 99%

Does β-Hydroxy-β-Methylbutyrate Have Any Potential to Support the Treatment of Duchenne Muscular Dystrophy in Humans and Animals?

Gorji,

Ostaszewski,

Urbańska

et al. 2023

Biomedicines

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“…On one hand, acute studies assessing muscle and whole body protein turnover conducted in stable patients have consistently demonstrated an imbalance in protein synthesis and degradation during HD sessions[ 105 - 108 ]. It has been also shown that losses of amino acids during HD, ranging between 8 and 10 g per session, contributed significantly to the net protein catabolism[ 85 , 109 - 111 ].…”

Section: Intermittent Extracorporeal Renal Replacement Therapy Is The...mentioning

confidence: 99%

Hidden risks associated with conventional short intermittent hemodialysis: A call for action to mitigate cardiovascular risk and morbidity

Canaud¹,

Kooman²,

Selby³

et al. 2022

WJN

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The development of maintenance hemodialysis (HD) for end stage kidney disease patients is a success story that continues to save many lives. Nevertheless, intermittent renal replacement therapy is also a source of recurrent stress for patients. Conventional thrice weekly short HD is an imperfect treatment that only partially corrects uremic abnormalities, increases cardiovascular risk, and exacerbates disease burden. Altering cycles of fluid loading associated with cardiac stretching (interdialytic phase) and then fluid unloading (intradialytic phase) likely contribute to cardiac and vascular damage. This unphysiologic treatment profile combined with cyclic disturbances including osmotic and electrolytic shifts may contribute to morbidity in dialysis patients and augment the health burden of treatment. As such, HD patients are exposed to multiple stressors including cardiocirculatory, inflammatory, biologic, hypoxemic, and nutritional. This cascade of events can be termed the dialysis stress storm and sickness syndrome. Mitigating cardiovascular risk and morbidity associated with conventional intermittent HD appears to be a priority for improving patient experience and reducing disease burden. In this in-depth review, we summarize the hidden effects of intermittent HD therapy, and call for action to improve delivered HD and develop treatment schedules that are better tolerated and associated with fewer adverse effects.

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“…Monitoring training is becoming indispensable to fine-tune the dose-response and, ultimately, improving performance. Muscle oxygen saturation (SmO 2 ) has been gaining emphasis as a local muscle measurement at rest and during exercise [ 12 ], not only in terms of sports performance [ 13 ] but also in terms of health [ 14 , 15 ]. Near-infrared spectroscopy (NIRS) is a non-invasive method that continuously monitors information about the changes in oxygenation and haemodynamics in muscle tissue [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Comparing the effects of dynamic and holding isometric contractions on cardiovascular, perceptual, and near-infrared spectroscopy parameters: A pilot study

et al. 2023

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The aim of this pilot study was to assess the effect of muscle contraction type on SmO2 during a dynamic contraction protocol (DYN) and a holding isometric contraction protocol (ISO) in the back squat exercise. Ten voluntary participants (age: 26.6 ± 5.0 years, height: 176.8 ± 8.0 cm, body mass: 76.7 ± 8.1 kg, and one-repetition maximum (1RM): 112.0 ± 33.1 kg) with back squat experience were recruited. The DYN consisted of 3 sets of 16 repetitions at 50% of 1RM (56.0 ± 17.4 kg), with a 120-second rest interval between sets and 2 seconds per movement cycle. The ISO consisted of 3 sets of 1 isometric contraction with the same weight and duration as the DYN (32 seconds). Through near-infrared spectroscopy (NIRS) in the vastus lateralis (VL), soleus (SL), longissimus (LG), and semitendinosus (ST) muscles, the minimum SmO2 (SmO2 min), mean SmO2 (SmO2 avg), percent change from baseline (SmO2 Δdeoxy) and time to recovery 50% of baseline value (t SmO2 50%reoxy) were determined. No changes in SmO2 avg were found in the VL, LG, and ST muscles, however the SL muscle had lower values in DYN, in the 1st set (p = 0.002) and in the 2nd set (p = 0.044). In terms of SmO2 min and ΔSmO2 deoxy, only the SL muscle showed differences (p≤0.05) and lower values in the DYN compared to ISO regardless of the set. The t SmO2 50%reoxy was higher in the VL muscle after ISO, only in the 3rd set. These preliminary data suggested that varying the type of muscle contraction in back squat with the same load and exercise time resulted in a lower SmO2 min in the SL muscle in DYN, most likely because of a higher demand for specialized muscle activation, indicating a larger oxygen supply-consumption gap.

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A Systematic Review of the Acute Effects of Hemodialysis on Skeletal Muscle Perfusion, Metabolism, and Function

Cited by 9 publications

References 48 publications

Does β-Hydroxy-β-Methylbutyrate Have Any Potential to Support the Treatment of Duchenne Muscular Dystrophy in Humans and Animals?

Does β-Hydroxy-β-Methylbutyrate Have Any Potential to Support the Treatment of Duchenne Muscular Dystrophy in Humans and Animals?

Hidden risks associated with conventional short intermittent hemodialysis: A call for action to mitigate cardiovascular risk and morbidity

Comparing the effects of dynamic and holding isometric contractions on cardiovascular, perceptual, and near-infrared spectroscopy parameters: A pilot study

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