A systematic review of serologic tests in the diagnosis of necrotizing enterocolitis

Evennett, Nicholas; Alexander, Nic; Petrov, Maxim S.; Pierro, Agostino; Eaton, Simon

doi:10.1016/j.jpedsurg.2009.07.028

Cited by 50 publications

(34 citation statements)

References 60 publications

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“…Therefore, its delayed occurrence after birth, its rapid onset, highly fulminant nature, and progression to death, as well as its severe morbidity, require identification of prospective new biomarkers specific for high NEC risk (Young et al 2009). Some studies have suggested the efficacy of several inflammatory mediators such as C-reactive protein (CRP), interleukin-6 (IL-6) and serum amyloid A (SAA) measurements in the diagnosis of NEC (Pourcyrous et al 2005;Hallstrom et al 2006;Markel et al 2006;Evennett et al 2009;Cetinkaya et al 2010). These all have difficulties that limit their use.…”

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confidence: 99%

C5a, A Complement Activation Product, Is a Useful Marker in Predicting the Severity of Necrotizing Enterocolitis

Tayman

Tonbul

Kahveci³

et al. 2011

Tohoku J. Exp. Med.

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Necrotizing enterocolitis (NEC) is the most common neonatal gastrointestinal emergency, predominantly affecting low-birth weight, premature infants. Early clinical signs of NEC are nonspecific and the laboratory findings are not fully reliable. Its severe morbidities and rapid progression require the application of new biomarkers for early diagnosis and intervention. The complement activation product, C5a (anaphylatoxin) has been reported to be a contributing factor leading to mesenteric ischemia/reperfusion injury which is a predisposing factor in the pathogenesis of NEC. Therefore, our aim was to evaluate the efficacy of serial C5a measurements in the diagnosis and follow-up of NEC. Preterm infants, whose gestational age and weight matched each other, were grouped as controls (n = 23) and NEC (n = 22). Serum levels of C5a, serum amyloid-A (SAA), C-reactive protein (CRP), and interleukin-6 (IL-6) levels were measured on the third day of life for the control group and on the day of diagnosis (1 st day), 3 rd and 7 th days of the NEC group. C5a, SSA, CRP, and IL-6 levels were significantly higher in the NEC patients compared to the control group (P < 0.05) in the follow-up. Additionally, serum levels of C5a were found to be more accurate than the other parameters for the prediction of death and requirement for surgery at the time of diagnosis (P < 0.05). In conclusion, C5a may be useful as a new marker for both diagnosis and follow-up of infants with NEC in combination with clinical and radiographical findings.

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confidence: 99%

C5a, A Complement Activation Product, Is a Useful Marker in Predicting the Severity of Necrotizing Enterocolitis

Tayman

Tonbul

Kahveci³

et al. 2011

Tohoku J. Exp. Med.

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“…Many researchers have studied the different angles of aetiology including indicators and immunological markers of the disease for early diagnosis and effective treatment [6]. Evenett et al carried out a systematic review of the studies carried out on serological tests which may be useful in the diagnosis of NEC [7]. In this review, Plateletactivating factor (PAF) and intestinal fatty acid binding protein (I-FABP) were found to have specificity and sensitivity for NEC, however they specified that this must be tested in larger scoped prospective studies [7].…”

Section: Discussionmentioning

confidence: 99%

“…Evenett et al carried out a systematic review of the studies carried out on serological tests which may be useful in the diagnosis of NEC [7]. In this review, Plateletactivating factor (PAF) and intestinal fatty acid binding protein (I-FABP) were found to have specificity and sensitivity for NEC, however they specified that this must be tested in larger scoped prospective studies [7]. Direct x-ray, is one of the cornerstones of radiological imaging of infants thought to have NEC in neonatal intensive care units, however it is relatively weak in terms of sensitivity and specificity [2,5].…”

Section: Discussionmentioning

confidence: 99%

Making decisions for surgical intervention in neonates with necrotizing enterocolitis and the selection of appropriate surgical intervention

Cerit¹,

Ergelen²,

Abdullayev³

et al. 2017

Marmara Medical Journal

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two other grade III patients based on the radiological findings. However, due to the appearance of necrotic bowel segments from the incision site, they underwent bowel resection and ileostomy during a bedside laparotomy. One of these patients improved clinically, but the other patient was lost in the early stages. Due to the deterioration seen in the clinical findings of 5 patients who were radiologically grade II, the decision for laparotomy was made initially. All of these 5 patients were discharged after an uneventful postoperative period. Conclusion:In patients who are grade II radiologically, the decision for surgical intervention in an operating room can be made according to clinical deterioration. In infants who are grade III, and whose clinical condition is poor, bedside surgical intervention in the neonatal intensive care unit is preferable..

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“…Они являются важной составляющей врожденной иммунной системы, которая обеспечива-ет защиту против широкого спектра бактерий, грибов и вирусов [6]. Несмотря на то, что о существовании анти-микробных пептидов и белков известно уже достаточно времени, только недавно интерес к этим молекулам перешел из плоскости фундаментальных исследований иммунной системы в клиническую область.…”

Section: оригинальная статьяunclassified

Prognostic Significance of Katelicidin in Neonates

Minaev¹,

Obedin²,

Bolotov³

et al. 2012

Pediatr. farmakol.

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A systematic review of serologic tests in the diagnosis of necrotizing enterocolitis

Cited by 50 publications

References 60 publications

C5a, A Complement Activation Product, Is a Useful Marker in Predicting the Severity of Necrotizing Enterocolitis

C5a, A Complement Activation Product, Is a Useful Marker in Predicting the Severity of Necrotizing Enterocolitis

Making decisions for surgical intervention in neonates with necrotizing enterocolitis and the selection of appropriate surgical intervention

Prognostic Significance of Katelicidin in Neonates

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