A systematic review of pharmacokinetic studies on herbal drug Fuzi : Implications for Fuzi as personalized medicine

Wu, Jinjun; Guo, Zhenzhen; Zhu, Yuanfeng; Huang, Zhijian; Gong, Xia; Li, Yuhuan; Son, Wen-jie; Li, Xiaoyan; Lou, Yanmei; Zhu, Lijun; Lu, Linlin; Liu, Zhongqiu; Liu, Liang

doi:10.1016/j.phymed.2018.03.001

Cited by 83 publications

(53 citation statements)

References 81 publications

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“…As a traditional Chinese medicine, radix aconiti carmichaeli (Fuzi) promotes heat production and protects from cold [22,23]. As the major ingredient from radix aconiti carmichaeli (Fuzi), the aconitum alkaloids mainly produce their pharmacological effects by regulating heart and blood vessel functions [24]; however, the key active ingredients from radix aconiti carmichaeli (Fuzi) which regulate BAT activity and liver metabolism in cold acclimation are still unknown. In order to elucidate the key substance that plays a role in this effect, we got a new active ingredient which is purified from Fuzi.…”

Section: Discussionmentioning

confidence: 99%

Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance

Xue

Liu

et al. 2018

IJMS

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Trans-ferulic acid-4-β-glucoside (C16H20O9, TFA-4β-G) is a monomer extracted from the Chinese medicine called radix aconiti carmichaeli (Fuzi). To date, research on this substance is lacking. Here, we found that trans-ferulic acid-4-β-glucoside effectively promoted cold acclimatization in mice via increased heat production and alleviation of oxidative stress in a cold environment. Thus, our work indicates that ferulic acid-4-β-glucoside is a potential therapeutic candidate for prevention and treatment of cold stress injury.

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Section: Discussionmentioning

confidence: 99%

Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance

Xue

Liu

et al. 2018

IJMS

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“…The major ones are C 19 -diterpenoid alkaloids, which only occur the Aconitum species [ 1 ] and can be further divided into diester-diterpenoid alkaloids (DDAs), monoester-diterpenoid alkaloids (MDAs), and non-esterified diterpenoid alkaloids (NDAs) ( Figure 1 ) [ 1 ]. The C 19 -diterpenoid alkaloids are also believed to be responsible for some toxicities and certain pharmacological activities of A. carmichaelii [ 1 , 2 , 18 ]. Three main DDAs, AC, HA, and MA as shown in Figure 1 , share a common C 19 -norditerpenoid skeleton, in which the C8 and C14 position can be occupied by an acetoxy, a benzoxy, or a hydroxyl group [ 1 , 2 , 18 ].…”

Section: Classification Of Aconitum Alkaloidsmentioning

confidence: 99%

“…The C 19 -diterpenoid alkaloids are also believed to be responsible for some toxicities and certain pharmacological activities of A. carmichaelii [ 1 , 2 , 18 ]. Three main DDAs, AC, HA, and MA as shown in Figure 1 , share a common C 19 -norditerpenoid skeleton, in which the C8 and C14 position can be occupied by an acetoxy, a benzoxy, or a hydroxyl group [ 1 , 2 , 18 ]. DDAs are not stable due to the acetyl groups at C8 position and benzoyl at the C14 position, which are easily hydrolyzed in the presence of water or heat [ 1 , 2 , 4 , 20 ].…”

Section: Classification Of Aconitum Alkaloidsmentioning

confidence: 99%

“…Since the absorption, distribution, metabolism, and excretion properties of these toxic ingredients are expected to determine the safe dose of the herb, understanding of the toxicity and toxicokinetic properties of the main toxic DDAs is essential for the dosage regimen and risk control of Fuzi. The pharmacokinetics of Fuzi and their biological mechanisms have been well-delineated and reviewed [ 18 ]. Based on the previous publications on toxicity and toxicokinetics of Fuzi and its DDAs, our current review aims to investigate the toxicity–toxicokinetic relationship of Fuzi and its main toxic DDAs, which may serve as references for further clinical safety assessment.…”

Section: Introductionmentioning

confidence: 99%

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Relationships between the Toxicities of Radix Aconiti Lateralis Preparata (Fuzi) and the Toxicokinetics of Its Main Diester-Diterpenoid Alkaloids

Yang

Zuo

2018

Toxins

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The processed lateral root of Aconitum carmichaelii Deb (Aconiti Radix lateralis praeparata or Fuzi) is a potent traditional herbal medicine extensively used in treatment of cardiovascular diseases, rheumatism arthritis, and bronchitis in many Asian countries. Although Fuzi has promising therapeutic effects, its toxicities are frequently observed. Three main C19-diester-diterpenoid alkaloids (DDAs) are believed to be the principal toxins of the herb. Although toxicokinetic profiles of the toxic DDAs have already been examined in several studies, they have seldom been correlated with the toxicities of Fuzi. The current article aimed to investigate the relationship between the up-to-date toxicokinetic data of the toxic DDAs and the existing evidence of the toxic effects of Fuzi. Relationships between the cardiac toxicity and the plasma and heart concentration of DDAs in mice and rats were established. Based on our findings, clinical monitoring of the plasma concentrations of DDAs of Fuzi is recommended to prevent potential cardiac toxicities. Additionally, caution with respect to potential hepatic and renal toxicity induced by Fuzi should be exercised. In addition, further analyses focusing on the preclinical tissue distribution profile of DDAs and on the long-term toxicokinetic-toxicity correlation of DDAs are warranted for a better understanding of the toxic mechanisms and safer use of Fuzi.

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“…C 19 ‐diterpenoid alkaloids are the major bioactive compounds. Simultaneously, aconitine (AC), mesaconitine (MA), and hypaconitine (HA) are the main toxic ingredients in Fuzi (Table ). The number of ester groups in the diterpene skeleton considerably affects the cytotoxicity .…”

Section: Introductionmentioning

confidence: 99%

Neuropharmacological effects of Aconiti Lateralis Radix Praeparata

Zhao

Sun

Yang

et al. 2020

Clin Exp Pharma Physio

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Aconiti Lateralis Radix Praeparata (Fuzi in Chinese), which are the lateral roots of Aconitum Carmichaelii Debx, is widely used in China to treat many neurological diseases. Fuzi, in its various forms, has many neuropharmacological effects. It can act as an analgesic and help with depression, epilepsy, and dementia. However, the neuropharmacological effects of Aconiti Lateralis Radix Praeparata are seldom comprehensively reviewed. In this review, the neuropharmacological activities of some components contained in Aconiti Lateralis Radix Praeparata are considered. These include aconitine, mesaconitine, hypaconitine, total alkaloid, polysaccharide‐1, benzoylmesaconine, fuziline, songorine, and napelline. We also specifically discuss the antidepressant effects of total alkaloids and polysaccharide‐1. This review may provide a theoretical basis for further utilization of Aconiti Lateralis Radix Praeparata for diseases that affect the central nervous system.

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A systematic review of pharmacokinetic studies on herbal drug Fuzi : Implications for Fuzi as personalized medicine

Cited by 83 publications

References 81 publications

Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance

Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance

Relationships between the Toxicities of Radix Aconiti Lateralis Preparata (Fuzi) and the Toxicokinetics of Its Main Diester-Diterpenoid Alkaloids

Neuropharmacological effects of Aconiti Lateralis Radix Praeparata

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