A systematic review of outbreaks of bloodborne infections (hepatitis B and C, HIV) transmitted from patient to patient in healthcare settings

Satsuk, A.V.; Solopova, G.G.; Плоскирева, А. А.

doi:10.36233/0372-9311-112

Cited by 2 publications

(1 citation statement)

References 38 publications

(31 reference statements)

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“…The European Network for Hepatitis B and C Surveillance [ 5 ] in 2015 recommended that a systematic review of published events of healthcare-associated transmission of hepatitis B and C in countries be carried out, in order to complement the surveillance data and bring about a better understanding of the determinants behind healthcare-associated transmission of HBV/HCV. While previous reviews of healthcare-associated transmission have been conducted [ 6 , 7 ], there have been no recent reviews conducted focused on EU/EEA countries.…”

Section: Introductionmentioning

confidence: 99%

Healthcare-associated hepatitis B and C transmission to patients in the EU/EEA and UK: a systematic review of reported outbreaks between 2006 and 2021

et al. 2022

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Healthcare-associated transmission was the second most common hepatitis B (HBV) and hepatitis C (HCV) transmission route according to 2006–2012 European surveillance data, but data quality and completeness issues hinder comprehensive characterisation of this important issue. We carried out a systematic review of published literature on healthcare-associated transmission of HBV or HCV in European Union (EU) and European Economic Area (EEA) countries and the United Kingdom to complement surveillance data and identify higher-risk settings. We searched the PubMed and Embase databases and grey literature over the period January 2006 to September 2021, for publications reporting transmission events after 2000 in the EU/EEA and UK related to a healthcare setting or procedure. We collected data on the country, number of patients, setting type and route of transmission. In 65 publications from 16 countries, 43 HBV and 48 HCV events were identified resulting in 442 newly infected patients. Most events were reported from Italy (7 HBV and 12 HCV), Germany (8 HBV and 5 HCV) and the United Kingdom (8 HBV and 5 HCV). The number of patients infected from a single source within an event ranged from 1 to 53. Five large outbreaks of over 20 cases were identified, including two in Poland and one each in Belgium, Hungary and Slovakia. The majority of transmission events occurred through blood transfusions or in dialysis units. However, there were a number of outbreaks in seemingly low risk settings such as CT/MRI scanning units. A failure to adequately follow infection prevention control (IPC) precautions was reported in 30% of included studies. Healthcare-associated transmission of hepatitis B and C continues to occur in a range of community and hospital settings across EU/EEA countries and often results in large outbreaks, although the true extent of the situation cannot be fully determined due to under-reporting. Strict IPC precautions should be implemented across all healthcare settings and regularly audited, and surveillance systems strengthened and standardised to allow for comprehensive and consistent reporting of nosocomial transmission of hepatitis across the EU.

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Section: Introductionmentioning

confidence: 99%

Healthcare-associated hepatitis B and C transmission to patients in the EU/EEA and UK: a systematic review of reported outbreaks between 2006 and 2021

et al. 2022

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Systematic review of seroprevalence of markers of hepatitis B, C and HIV among oncohematological patients

Satsuk,

Solopova,

Ploskireva

et al. 2023

CMAC

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The purpose of systematic review was to assess the incidence of blood-borne infections in oncohematological patients in the period from 1980 to 2020 in different countries of the world, including in main oncohematological clinical groups of patients, assessment of the dynamics of the prevalence of blood-borne infections in the high-risk group after implementation of blood transfusion safety measures. An analysis of the data of the systematic review showed a high incidence of patients with oncohematological diseases in the period from 1980 to 2020: HCV – 8.2%, HBV (total markers) – 14.7% (HBsAg – 10.8%), HIV – 0.4 %. Middle levels of HCV and HBV infection in patients in the period from 2009 to 2017 exceeded the infection levels of the population in 2015 by 3.9 and 1.6 times, respectively. The prevalence of HIV was 1.16 times lower. According to the data of individual countries, the incidence of HCV among oncohematological patients is 1.3-118 times higher than the population, HBV – 0.4-73.5 times. The prevalence of HBsAg among children with oncohematological diseases was 18.3% and exceeded the same level among adult patients (7.1%) by 2.6 times. The prevalence of HBsAg among children with oncohematological diseases before 2000 was 14.8% and exceeded the prevalence of HBsAg among the child population before 2000 by 3 times, after 2000 – 20.5% and exceeded that among the child population by 16 times. The introduction of screening of blood donors has significantly reduced the incidence of patients at risk. Prior to the introduction of screening, the level of HCV infection among oncohematological patients was 35.7%, after the introduction of screening it was 5.2%, which is 7 times less. The level of HBV infection in the pre-screening period was 41.3%, after the introduction of screening – 5.9%, which is also 7 times less. During the course of treatment of oncohematological diseases or after its completion, the infection of patients with HCV is 7.7 times higher, HBV – 4.2 times higher, compared with infection at the stage of diagnosis or start of treatment. The level of HCV and HBV infection in patients with hematological malignancies exceeded that in patients with solid tumors by 1.8 times, both in the case of HCV and HBV. The conducted analysis emphasizes the urgency of the problem of nosocomial transmission of blood-borne infections, which is actively realized among patients at risk.

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A systematic review of outbreaks of bloodborne infections (hepatitis B and C, HIV) transmitted from patient to patient in healthcare settings

Cited by 2 publications

References 38 publications

Healthcare-associated hepatitis B and C transmission to patients in the EU/EEA and UK: a systematic review of reported outbreaks between 2006 and 2021

Healthcare-associated hepatitis B and C transmission to patients in the EU/EEA and UK: a systematic review of reported outbreaks between 2006 and 2021

Systematic review of seroprevalence of markers of hepatitis B, C and HIV among oncohematological patients

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