A systematic review of Mancozeb as a reproductive and developmental hazard

Runkle, Jennifer D.; Flocks, Joan; Economos, Jeannie; Dunlop, Anne L.

doi:10.1016/j.envint.2016.11.006

Cited by 82 publications

(44 citation statements)

References 37 publications

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Section: Introductionmentioning

confidence: 79%

“…One of the most important endocrine disruptors, with a wide range of agricultural and industrial applications, is mancozeb. Mancozeb (ethylene bis-dithiocarbamate fungicide (EBCD)) was first registered in the United States in 1948 [21] and introduced in the global fungicide market in 1962 [22]. Mancozeb fungicidal efficacy has been applied in different agricultural and industrial contexts, for example in major agricultural crops (tomato, potato, grapevine), and its use will likely increase by the 2020s due to its low price, global demand for fruits and vegetables, and non-selective fungicidal efficacy [21].…”

Section: Introductionmentioning

confidence: 99%

“…Mancozeb (ethylene bis-dithiocarbamate fungicide (EBCD)) was first registered in the United States in 1948 [21] and introduced in the global fungicide market in 1962 [22]. Mancozeb fungicidal efficacy has been applied in different agricultural and industrial contexts, for example in major agricultural crops (tomato, potato, grapevine), and its use will likely increase by the 2020s due to its low price, global demand for fruits and vegetables, and non-selective fungicidal efficacy [21]. In this context, the main source of exposure to mancozeb is the assumption of contaminated products (e.g., tomatoes, potatoes, citrus fruits) or drinking water [21], while occupational exposure includes inhalation, accidental ingestion, and dermal contact of the fungicide, among industrial and agricultural workers [21].…”

Section: Introductionmentioning

confidence: 99%

“…Mancozeb exposure induces a wide range of environmental hazard, such as Parkinson-like symptoms, thyroid hormone dysfunctions, and defects in fetal development [21,23]. As confirmed by recent studies, mancozeb exposure is a risk factor for spontaneous abortion, maternal mortality, and fetal malformations in rat and rabbit experimental models [21]. Moreover, it is strongly linked to teratogenic, mutagenic, and carcinogenic risks [24] because of its ability to induce genotoxic and malignant alterations in human ovarian cells [21,25,26].…”

Section: Introductionmentioning

confidence: 99%

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Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models

Bianchi

Nottola

Torge

et al. 2020

IJERPH

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Mancozeb is a widely used fungicide approved for use in agriculture in many countries with long persistence in the environment and consequent bioaccumulation in tissues and biological fluids. Despite the large amount of studies published in recent years, the relationship between mancozeb exposure and female reproductive health is not fully elucidated. In order to summarize current evidence on mancozeb exposure and female reproductive disease, we performed a systematic review of literature. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to make this review. An adapted version of the National Toxicology Program's Office of Health and Assessment and Translation (OHAT) framework was used to evaluate the risk of bias. Electronic search on two databases (PubMed and Scopus) was used to find experimental studies (in vitro and in vivo) on mancozeb exposure. The database search identified 250 scientific articles, 20 of which met our inclusion criteria. Selected data were then reviewed and summarized in tables. Overall, mancozeb represents a hazard for female reproductive health, with different mechanisms of action. Undoubtedly more experimental and epidemiological studies are required to definitively validate mancozeb as reproductive toxicant.

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Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models

Bianchi

Nottola

Torge

et al. 2020

IJERPH

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“…A major limitation to the use of chemical fungicides is that they may produce environmental and health hazards . Interestingly, in spite of its ability to control S. rolfsii , both in vitro and in soil (Figs and ), the compound trans ‐2‐octenal is used in the food industry (http://www.sigmaaldrich.com/industries/flavors-and-fragrances.html), which implies that its toxicity is lower than that of other fungicides . However, the exact effect of trans ‐2‐octenal on the environment is still obscure; it should be examined before application in the field.…”

Section: Discussionmentioning

confidence: 99%

trans‐2‐Octenal, a single compound of a fungal origin, controls Sclerotium rolfsii, both in vitro and in soil

Liarzi

Benichis

Gamliel

et al. 2020

Pest Management Science

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BACKGROUND: Sclerotium rolfsii is a soil-borne phytopathogenic fungus that causes diseases in economically important crops. Eradication of the fungus is hampered by its wide range of hosts, as well as its capacity to form sclerotia. Recently, we have shown that the endophytic fungus Daldinia cf. concentrica emits biologically active volatile organic compounds (VOCs); we also demonstrated that one VOC, trans-2-octenal, was the most effective against various phytopathogenic fungi. Thus, the aim of this study was to examine the potential of this compound to control hyphae and sclerotia of S. rolfsii, both in vitro and in soil. RESULTS:We found that in vitro exposure of S. rolfsii mycelium to trans-2-octenal in air fully inhibits and kills the fungus. Elimination of sclerotia viability occurred at the same concentration, but direct contact between the sclerotia and the compound was needed. trans-2-Octenal also affected the viability of both hyphae and sclerotia of S. rolfsii in small pots containing loam soil.CONCLUSION: We suggest the use of trans-2-octenal as a novel compound to control S. rolfsii.

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Pesticides

Rubino

Mandić‐Rajčević

Colosio

2020

Kirk-Othmer Encyclopedia of Chemical Technology

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Pesticides are substances or mixtures used to control living organisms that damage crops or goods, transmit or cause diseases and other unwanted events, such as the uncontrolled expansion of endogenous living species, or infestation by non‐native ones. Unwanted living organisms include animals, such as insects and rodents, invading plants, such as weeds and ornamental flowers, shrubs and trees, microorganisms and viruses that cause transmittable diseases to plants, animals, and humans.

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A systematic review of Mancozeb as a reproductive and developmental hazard

Cited by 82 publications

References 37 publications

Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models

Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models

trans‐2‐Octenal, a single compound of a fungal origin, controls Sclerotium rolfsii, both in vitro and in soil

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