Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models

Abstract

Mancozeb is a widely used fungicide approved for use in agriculture in many countries with long persistence in the environment and consequent bioaccumulation in tissues and biological fluids. Despite the large amount of studies published in recent years, the relationship between mancozeb exposure and female reproductive health is not fully elucidated. In order to summarize current evidence on mancozeb exposure and female reproductive disease, we performed a systematic review of literature. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to make this review. An adapted version of the National Toxicology Program's Office of Health and Assessment and Translation (OHAT) framework was used to evaluate the risk of bias. Electronic search on two databases (PubMed and Scopus) was used to find experimental studies (in vitro and in vivo) on mancozeb exposure. The database search identified 250 scientific articles, 20 of which met our inclusion criteria. Selected data were then reviewed and summarized in tables. Overall, mancozeb represents a hazard for female reproductive health, with different mechanisms of action. Undoubtedly more experimental and epidemiological studies are required to definitively validate mancozeb as reproductive toxicant.

The More Fertile, the More Creative: Changes in Women’s Creative Potential across the Ovulatory Cycle

“…Women’s exposure to pesticides on a daily basis is considered a significant risk factor in fertility problems [ 5 ]. Pesticides, such as Mancozeb, can lead to delayed ovulation and menstrual cycle disruptions, and as such impede female fertility (see [ 112 ], for a review). These results lead to a worrying conclusion.…”

Fitossanitários e doenças hepáticas: Um desafio à saúde pública no Brasil

“…Isso decorre pelo seu baixo custo, eficácia contra aproximadamente 400 pragas diferentes, e por ser adotado no plantio de frutas e vegetais (Runkle et al, 2017;Bianchi et al, 2020). O mancozeb caracteriza-se como um fungicida de etileno bisditiocarbamato (EBCD) não seletivo com metabólitos etilenotiouréia (ETU), sendo sua toxicidade dada pela ativação de radicais livre em detrimento do sistema de defesa antioxidante, por meio da inibição da atividade enzimática (Aranha et al, 2021).…”

The Effect of Menopause Hypoestrogenism on Osteogenic Differentiation of Periodontal Ligament Cells (PDLC) and Stem Cells (PDLCs): A Systematic Review

“…Investigations concerning the oral microcirculation in postmenopausal women have revealed that the diameter of the loops, tortuosity of vessels in labial mucosa and density of periodontal mucosa are altered and predispose to periodontal inflammation. The swelling of endothelial cells and periocytes of the venules, adherence of granulocytes and platelets to vessel walls, increased vascular permeability and vascular proliferation have been associated with variations in the oestrogen levels [ 6 , 7 , 8 ]. The suppressed oestrogen activity is the suggested major common cause of the decrease of alveolar bone remodelling [ 1 , 2 , 3 ].…”

“…Indeed, the balance between the number and activity of osteoblasts and osteoclasts carry out this cycle. In vivo and in vitro studies demonstrated that disruption of the positive feedback on the hypothalamic-pituitary-ovarian axis leads to development of alveolar bone resorption [ 4 , 7 ]. One of the major events that cause the progressive architectural disruption of the periodontium during menopause is the impairment of the normal alveolar bone remodelling cycle, via the excessive release of the cytokines among them RANK ligand (RANKL—nuclear factor-kappa B ligand) by osteoblasts, which are directly implicated in the osteoclastogenesis cascade.…”