A systematic review of human biomonitoring studies of 3-phenoxybenzoic acid, a urinary biomarker pyrethroid insecticide exposure, 1997 to 2019

Lehmler, Hans‐Joachim; Simonsen, Derek; Garcia, Alana Quintero; Irfan, Nafis Md.; Dean, Laura E.; Wang, Hui; Elsterman, Mirko von; Li, Xueshu

doi:10.1016/j.heha.2022.100018

Cited by 2 publications

(2 citation statements)

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“…Previous urine biomonitoring research utilized glucuronidase/sulfatase enzymes for deconjugation, which may lead to underestimation of 3-PBA levels as they only release the compound from its conjugated forms. 8 Therefore, a strong acid treatment and heating step are required before analyzing 3-PBA residues in urine samples. 9 However, developing rapid, sensitive, and acidic-resistance analytical methods remains a challenge for detection of 3-PBA in urine.…”

Section: Introductionmentioning

confidence: 99%

Streptavidin-biotin system-mediated immobilization of a bivalent nanobody onto magnetosomes for separation and analysis of 3-phenoxybenzoic acid in urine

Tang,

Wang,

Wang

et al. 2024

Anal. Methods

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Section: Introductionmentioning

confidence: 99%

Streptavidin-biotin system-mediated immobilization of a bivalent nanobody onto magnetosomes for separation and analysis of 3-phenoxybenzoic acid in urine

Tang,

Wang,

Wang

et al. 2024

Anal. Methods

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“…Urinary 3-PBA and 4F-3BPA have been extensively used as biomarkers, indicating pyrethroid exposure levels in humans. In particular, the rate of detection of urinary 3-PBA in the general population of different countries and regions is usually >60% and even exceeds 90%, with geometric mean (GM) concentrations ranging from 0.2 to 2 μg/L, suggesting widespread human exposure to pyrethroids. − Thus, the human health risks of pyrethroid exposure continue to be of concern.…”

Section: Introductionmentioning

confidence: 99%

First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

Ma,

Song,

et al. 2024

Environ. Sci. Technol. Lett.

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Pyrethroids, a class of extensively used insecticides, may pose health risks to humans. Whether pyrethroid exposure contributes to the development of gestational diabetes mellitus (GDM) in pregnant women remains unknown. The potential association of urinary concentrations of pyrethroid metabolites [3-phenoxybenzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzoic acid] with the risk of GDM was assessed using a nested case-control study of 220 GDM cases and 440 controls from a prospective cohort. The mediation roles of oxidative stress biomarkers [advanced glycation end products (AGEs) and malondialdehyde (MDA)] in the associations were investigated. Urinary concentrations of 3-PBA in these cases were significantly higher than those of the controls. Urinary 3-PBA was positively associated with the risk of GDM. The adjusted odds of GDM significantly increased by 32% in each unit increment of the ln-transformed concentration of urinary 3-PBA. The significant dose−response relationships of GDM with serum AGEs (P trend = 0.03) and MDA (P trend < 0.001) were observed. However, there were no significant correlations between 3-PBA and AGEs or MDA, nor was there a significant mediation effect of AGEs or MDA on the association of 3-PBA with GDM. We provide the first evidence that early gestational exposure to pyrethroids is an environmental risk factor for GDM.

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A systematic review of human biomonitoring studies of 3-phenoxybenzoic acid, a urinary biomarker pyrethroid insecticide exposure, 1997 to 2019

Cited by 2 publications

References 93 publications

Streptavidin-biotin system-mediated immobilization of a bivalent nanobody onto magnetosomes for separation and analysis of 3-phenoxybenzoic acid in urine

Streptavidin-biotin system-mediated immobilization of a bivalent nanobody onto magnetosomes for separation and analysis of 3-phenoxybenzoic acid in urine

First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

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