A Systematic Review of Global Alpha-Tocopherol Status as Assessed by Nutritional Intake Levels and Blood Serum Concentrations

Péter, Szabolcs; Friedel, Angelika; Roos, Franz F.; Wyss, Adrian; Eggersdorfer, Manfred; Hoffmann, Kristina; Weber, Peter

doi:10.1024/0300-9831/a000281

Cited by 88 publications

(82 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Troesch et al, in their review of nutritional surveys, reported that 75% of adults in both the United States and the United Kingdom do not meet the RDA level of intake [19]. Peter et al, in their review of global α-tocopherol status, estimated that the median intake of α-tocopherol is 6.2 mg/day and a median serum α-tocopherol concentration is 22.1 μM globally [20]. …”

Section: Intake and Metabolismmentioning

confidence: 99%

“…In subjects fed a vitamin E-deficient diet, the supplementation of 12 mg/day was sufficient to achieve a serum α-tocopherol concentration of 12 μM. The urine excretion of α-carboxyethyl hydroxychroman—a metabolite produced by a cytochrome P450 (CYP) enzymatic metabolism of α-tocopherol—increases, while exhaled air concentrations of pentane, a marker for oxidative stress, fall at serum concentrations of α-tocopherol above 30 μM, pointing to broader health benefits at this higher serum concentration [20]. …”

Section: Intake and Metabolismmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin E Nicotinate

Duncan

Suzuki

2017

Antioxidants

View full text Add to dashboard Cite

Vitamin E refers to a family of compounds that function as lipid-soluble antioxidants capable of preventing lipid peroxidation. Naturally occurring forms of vitamin E include tocopherols and tocotrienols. Vitamin E in dietary supplements and fortified foods is often an esterified form of α-tocopherol, the most common esters being acetate and succinate. The vitamin E esters are hydrolyzed and converted into free α-tocopherol prior to absorption in the intestinal tract. Because its functions are relevant to many chronic diseases, vitamin E has been extensively studied in respect to a variety of diseases as well as cosmetic applications. The forms of vitamin E most studied are natural α-tocopherol and the esters α-tocopheryl acetate and α-tocopheryl succinate. A small number of studies include or focus on another ester form, α-tocopheryl nicotinate, an ester of vitamin E and niacin. Some of these studies raise the possibility of differences in metabolism and in efficacy between vitamin E nicotinate and other forms of vitamin E. Recently, through metabolomics studies, we identified that α-tocopheryl nicotinate occurs endogenously in the heart and that its level is dramatically decreased in heart failure, indicating the possible biological importance of this vitamin E ester. Since knowledge about vitamin E nicotinate is not readily available in the literature, the purpose of this review is to summarize and evaluate published reports, specifically with respect to α-tocopheryl nicotinate with an emphasis on the differences from natural α-tocopherol or α-tocopheryl acetate.

show abstract

Section: Intake and Metabolismmentioning

confidence: 99%

Section: Intake and Metabolismmentioning

confidence: 99%

Vitamin E Nicotinate

Duncan

Suzuki

2017

Antioxidants

View full text Add to dashboard Cite

show abstract

“…It plays an important role in the maintenance of cardiovascular health, alleviation of cancer development, maintenance of immune system functioning as well as a neuro‐ and skin‐ protection in humans (Wolf, ; Azzi, ; Clarke et al ., ; Galli and Azzi, ; Frank et al ., ). Despite the relatively low incidence of acute vitamin E deficiency, many adults who have suboptimal tocopherol levels cannot achieve optimal health (Péter et al ., ). Vitamin E is an essential micronutrient of human diets.…”

Section: Introductionmentioning

confidence: 97%

An allele of ZmPORB2 encoding a protochlorophyllide oxidoreductase promotes tocopherol accumulation in both leaves and kernels of maize

et al. 2019

View full text Add to dashboard Cite

Summary Phytol is one of the key precursors for tocopherol synthesis in plants, however, the underlying mechanisms concerning the accumulation of tocopherol remain poorly understood. In this study, qVE5, a major QTL affecting tocopherol accumulation in maize kernels was identified via a positional cloning approach. qVE5 encodes a protochlorophyllide oxidoreductase (ZmPORB2), which localizes to the chloroplast. Overexpression of ZmPORB2 increased tocopherol content in both leaves and kernels. Candidate gene association analysis identified a 5/8‐bp insertion/deletion (InDel058) in the 5′ untranslated region (UTR) as the causal polymorphism in affecting ZmPORB2 expression and being highly associated with tocopherol content. We showed that higher expression of ZmPORB2 correlated with more chlorophyll metabolites in the leaf following pollination. RNA‐sequencing and metabolic analysis in near isogenic lines (NILs) support that ZmPORB2 participates in chlorophyll metabolism enabling the production of phytol, an important precursor of tocopherol. We also found that the tocopherol content in the kernel is mainly determined by the maternal genotype, a fact that was further confirmed by in vitro culture experiments. Finally, a PCR‐based marker based on Indel058 was developed in order to facilitate the high tocopherol (vitamin E) maize breeding.

show abstract

“…E per day). In 2016, Adults consumption were below recommendations according to a summary that more than 100 studies reported a dietary intake of 6.2 mg/day for α‐tocopherol …”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic and hepatoprotective synergistic effects of selenium nanoparticles and vitamin. E against acrylamide‐induced hepatic alterations in male albino mice

Hamza

Altalhi

Gobouri

et al. 2020

Applied Organom Chemis

View full text Add to dashboard Cite

The potential benefit of selenium nanoparticles (SeNPs) and vitamin E (Vit.E) that they are potent antioxidants , they were used as antioxidants against acrylamide (ACR) hepatotoxicity, ACR is found in the starchy foods that had been heated for long periods in high degrees above 120°C. So the aim of the current study was to elucidate the antihyperlipidemic and hepatoprotective effects of either SeNPs and/or Vit.E against ACR toxicity, SeNPs were characterized by SEM, EDX, TEM and they proved their spherical nanostructure. Zeta potential value was –22.9 mv with particle size with a diameter range (48.75‐67.24 nm) which proved the high stability of the used SeNPs. Seven groups of male mice were used: group I was control,group II ACR,group III was treated with SeNPs, IV group was received Vit.E and groups V,VI received ACR plus SeNPs and ACR plus Vit.E, group VII was given combination of SeNPs and Vit.E plus ACR,So,The effect of SeNPs and/or Vit.E were monitored against ACR hepatotoxicity and hyperlipidemia. ACR administration afforded significant elevation in the hepatic enzymes with severe alterations in the lipid metabolism. These findings clarified the efficacy of SeNPs and Vit.E by declining the high hepatic enzymes activities induced by ACR along with improving the lipid profile, elevation of the antioxidant enzymes (SOD,CAT and GRx), reduction of MDA level, improving histological and ultrastructutral hepatic tissues and restoration of most normal structures that were damaged in ACR group. So, SeNPs and/or Vit.E were proved to enhance the hepatic antioxidant capacities.

show abstract

A Systematic Review of Global Alpha-Tocopherol Status as Assessed by Nutritional Intake Levels and Blood Serum Concentrations

Cited by 88 publications

References 25 publications

Vitamin E Nicotinate

Vitamin E Nicotinate

An allele of ZmPORB2 encoding a protochlorophyllide oxidoreductase promotes tocopherol accumulation in both leaves and kernels of maize

Hypolipidemic and hepatoprotective synergistic effects of selenium nanoparticles and vitamin. E against acrylamide‐induced hepatic alterations in male albino mice

Contact Info

Product

Resources

About