Hypolipidemic and hepatoprotective synergistic effects of selenium nanoparticles and vitamin. E against acrylamide‐induced hepatic alterations in male albino mice

Abstract

The potential benefit of selenium nanoparticles (SeNPs) and vitamin E (Vit.E) that they are potent antioxidants , they were used as antioxidants against acrylamide (ACR) hepatotoxicity, ACR is found in the starchy foods that had been heated for long periods in high degrees above 120°C. So the aim of the current study was to elucidate the antihyperlipidemic and hepatoprotective effects of either SeNPs and/or Vit.E against ACR toxicity, SeNPs were characterized by SEM, EDX, TEM and they proved their spherical nanostructure. Zeta potential value was –22.9 mv with particle size with a diameter range (48.75‐67.24 nm) which proved the high stability of the used SeNPs. Seven groups of male mice were used: group I was control,group II ACR,group III was treated with SeNPs, IV group was received Vit.E and groups V,VI received ACR plus SeNPs and ACR plus Vit.E, group VII was given combination of SeNPs and Vit.E plus ACR,So,The effect of SeNPs and/or Vit.E were monitored against ACR hepatotoxicity and hyperlipidemia. ACR administration afforded significant elevation in the hepatic enzymes with severe alterations in the lipid metabolism. These findings clarified the efficacy of SeNPs and Vit.E by declining the high hepatic enzymes activities induced by ACR along with improving the lipid profile, elevation of the antioxidant enzymes (SOD,CAT and GRx), reduction of MDA level, improving histological and ultrastructutral hepatic tissues and restoration of most normal structures that were damaged in ACR group. So, SeNPs and/or Vit.E were proved to enhance the hepatic antioxidant capacities.

The Effect of Copper Oxide and Selenium Nanoparticles on Vitamin D Levels in Women With Infertility

“…(Guo et al 2020), Reham Z. (Hamza et al 2020) and (Al-Quraishy, Adkhil, and Moneim 2015), mentioned, selenium nanoparticles reduce levels of triglycerides, cholesterol and low density lipoprotein, while increasing levels of high density lipoproteins. Which may explain the high levels of vitamin D after adding these particles to the serum, given the possibility of release of vitamin D from the fatty tissue.…”

“…Among the possible causes of vitamin D deficiency in a large proportion of the population, especially those who are overweight or obese, is the fact that the fat tissue has blocked vitamin D within it (McKay et al 2020;Pourshahidi 2015). As Leilei Guo et al (Guo et al 2020), Reham Z. Hamza et al (Hamza et al 2020) and Saleh Al-Quraishy et al (Al-Quraishy, Adkhil, and Moneim 2015), mentioned, selenium nanoparticles reduce levels of triglycerides, cholesterol and low density lipoprotein, while increasing levels of high density lipoproteins. Which may explain the high levels of vitamin D after adding these particles to the serum, given the possibility of release of vitamin D from the fatty tissue.…”

Recent Advances in Nanomedicine for the Diagnosis and Therapy of Liver Fibrosis

“…The mechanism involves the regulation of AKT/PI3K and MAPK signaling pathways by gold NPs, thereby reducing pro-inflammatory cytokine secretion and oxidative stress. Another study reported that vitamin E-modified selenium NPs can attenuate liver fibrosis by reducing oxidative stress [ 68 ].…”

In Situ Neutral System Synthesis, Spectroscopic, and Biological Interpretations of Magnesium(II), Calcium(II), Chromium(III), Zinc(II), Copper(II) and Selenium(IV) Sitagliptin Complexes

“…For many diseases, minerals are also used as inorganic medicines. However, the focus in this article is on of metal molecule interactions, as well as the chemistry and structure of metal complexes [1][2][3][4][5][6][7][8][9][10].…”

“…Current developments in the design of metal-based therapeutic agents have demonstrated increasingly important research attempts to develop new compounds with fewer toxic side effects [4][5][6][7][8]. The present article aimed to study the chemical structures of STG complexes with Mg 2+ , Ca 2+ , Cr 3+ , Zn 2+ , Cu 2+ , and Se 4+ using CHN elemental, molar conductance, FT-IR, magnetic susceptibility, electronic UV-Vis, 1 H NMR, thermogravimetric analysis (TGA/DrTGA), XRD, SEM, and TEM analyses.…”