A systematic review of circulating markers in primary chronic venous insufficiency

Smith, Ross K.; Golledge, Jonathan

doi:10.1177/0268355513494375

Cited by 13 publications

(10 citation statements)

References 37 publications

(147 reference statements)

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“…There is no clear consensus on which circulating biomarkers are associated with CVD. 13 Numerous hypotheses have been proposed to explain the mechanisms by which patients with venous hypertension and early stage venous disease progress to late stage venous disease. Major hypotheses that have been proposed include the pericapillary fibrin cuff theory, the growth factor trap hypothesis and the white cell trapping hypothesis.…”

Section: Introductionmentioning

confidence: 99%

“…[24][25][26][27] Limitations of the previous studies include small sample sizes (case subject range: 25-100), absence of examination of control populations by venous duplex ultrasonography and lack of adjustment for other risk factors. 13 The previous studies have also not focused on markers of more severe CVD and differ in their definitions of hyperhomocysteinemia. 24,25 In order to address these limitations, we sought to undertake a study to examine the association of circulating homocysteine with the skin complications of primary CVD with adjustment for potential confounding risk factors.…”

Section: Introductionmentioning

confidence: 99%

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Serum homocysteine is associated with the severity of primary chronic venous disease

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum homocysteine is associated with the severity of primary chronic venous disease

et al. 2015

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“…Fluid shear stress causes venous distension and causes increase in cellular responses. These changes trigger inflammatory mediators [21][22][23] . Karahan et al 24 evaluated the relationship between inflammatory markers and clinical severity of chronic venous insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Red Cell Distribution Width (Rdw) as a Diagnostic Tool for Chronic Venous Insufficiency

Yıldırım¹,

Çanakçı²,

Bayav³

2020

jocass

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Kronik venöz yetmezlik (KVY) kronik bir enflamatuar hastalıktır ve yayınlanan çalışmalarda bazı biyobelirteçlerin KVY hastaları için prediktif değeri olduğu gösterilmiştir. Eritrosit dağılım genişliği (RDW), dolaşımdaki eritrositlerin heterojenliğinin bir ölçüsüdür. Biz bu çalışma ile RDW ve KVY sınıflandırması arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntemler: Bu çalışmada alt ekstremite venöz Doppler ultrasonu çekilmiş 102 hasta değerlendirildi. Doppler ultrason sonuçları, hematolojik ve biyokimyasal laboratuvar sonuçları retrospektif olarak hastane tıbbi kayıtlarından elde edildi. Çalışma popülasyonu Doppler ultrason sonuçlarına göre kronik venöz yetmezlik grubu ve kontrol grubuna ayrıldı. Kronik venöz yetmezlik grubu CEAP sınıflandırmasının klinik bulgularına göre sınıflandırıldı. Bulgular: Toplam 102 hasta çalışmaya dahil edildi. Çalışma popülasyonunun ortalama yaşı 52.3±14.6 ve 54'ü (%52,9) erkekti. Hastaların%25,5'i CVI grubuna, %74,5'i kontrol grubuna alındı. Çalışma popülasyonunun CEAP sınıflandırmasının klinik bulgularına göre %21,6'sı (n=26) Sınıf 1, %44,1'i (n=45) Sınıf 2 ve %8,8'i (n=9) Sınıf 3 olarak sınıflandırıldı. RDW, venöz yetmezlik grubunda kontrol grubuna göre anlamlı derecede yüksekti (p = 0.02). İkili karşılaştırmada; Sınıf 1 ile Sınıf 2 arasında p= 0,150; Sınıf 1 ile Sınıf 3 arasında p = 0,125 ve Sınıf 2 ile Sınıf 3 arasında p= 0,05 saptandı. Sonuç: Sonuçlarımız RDW'nin CVI için bir tanı aracı olarak kullanılabileceğini, ancak CVI'nın şiddetinin RDW tarafından belirlenemeyeceğini göstermektedir.

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“…Additionally, a recent systematic review of the literature showed that circulating estradiol, homocysteine, and vascular endothelial growth factor were the markers most consistently associated with primary chronic venous insufficiency. 59 Another limitation is that the control group answered only the BDI score without a clinical assessment from a psychiatrist. In the DD group, some patients were already on antidepressant therapy, and thus this may have influenced their laboratory biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Carotid Intima-Media Thickness and Circulation Markers of Inflammation in Patients With Depression

Saleptsis

Papaliaga

Σπανός

et al. 2019

Journal of Diagnostic Medical Sonography

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Objective: Growing evidence indicates that depressive disorders (DDs) are an important risk factor for atherosclerosis. The aim of this study was to evaluate the presence of common carotid artery (CCA) intima-media thickness (IMT) and circulation inflammation markers in patients with DD. Methods: A cross-sectional prospective study was undertaken comparing 40 patients with DD to 40 individuals free of depression, matched for age and gender. The Beck Depression Inventory questionnaire, serum total cholesterol, triglycerides, high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor α, P-selectin, and E-selectin levels were measured. The CCA-IMT was assessed with duplex sonography. Results: Patients with DD were more likely to smoke (65% vs 40%; P = .03) and have higher levels of serum total cholesterol (211 mg/dL vs 181 mg/dL; P = .010), triglycerides (138 mg/dL vs 97 mg/dL; P = .005), and P-selectin (0.87 ng/mL vs 0.61 ng/mL; P = .05) and lower levels of interleukin 6 (4.4 ± 2.1 pg/mL vs 10.3 ± 1.1 pg/mL; P = .002). The CCA-IMT was similar in both groups (0.07 ± 0.02 cm vs 0.06 ± 0.01 cm; P = .31). Among those with CCA-IMT in the upper quartile, subjects in the DD group had lower levels of interleukin 6 ( P = .05) and triglycerides ( P = .01) and higher levels of soluble P-selectin ( P = .03). Conclusion: Patients with DD do not present with higher CCA-IMT than a control group, although smoking and a higher level of serum lipids are present. Inflammatory biomarkers seem to be higher in patients with DD.

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A systematic review of circulating markers in primary chronic venous insufficiency

Cited by 13 publications

References 37 publications

Serum homocysteine is associated with the severity of primary chronic venous disease

Serum homocysteine is associated with the severity of primary chronic venous disease

Red Cell Distribution Width (Rdw) as a Diagnostic Tool for Chronic Venous Insufficiency

Carotid Intima-Media Thickness and Circulation Markers of Inflammation in Patients With Depression

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