Serum homocysteine is associated with the severity of primary chronic venous disease

Smith, Ross K.; Quigley, Frank; Tosenovsky, Patrik; Velu, Ramesh; Bradshaw, Barbara; Buettner, Petra G.; Golledge, Jonathan

doi:10.1177/0268355515592076

Cited by 9 publications

(4 citation statements)

References 36 publications

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“…19 Several studies have revealed a positive correlation between serum Hcy and the severity of primary CVDs. 20,21 Our study also identified HHcy as a significant risk factor for the development of venous ulceration. In the study population, a high BMI seemed to have no effect on developing ulcers.…”

Section: Discussionsupporting

confidence: 62%

Elevated serum homocysteine levels are associated with the development of chronic venous ulcers

Guo

Wang

et al. 2022

Vasc Med

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Introduction: Venous ulceration is a multifactorial disease, and whether hyperhomocysteinemia (HHcy) promotes deterioration from primary varicose veins to venous ulcers remains unproven. Methods: This study retrospectively analyzed clinical data from 717 patients to investigate the potential correlation between HHcy and primary varicose veins ulcer formation, including 611 patients without ulcers (control group) and 106 with ulcers (case group). Results: In this study, 46.2% (49/106) of patients in the case group and 17.5% (107/611, p < 0.001) in the control group suffered from HHcy. Multivariate logistic analysis revealed that HHcy was closely associated with the incidence of venous ulceration in patients with primary varicose veins ( p < 0.001). Propensity score matching created 101 matched pairs of patients with and without ulcers, and the analysis pointed to a potential link between HHcy and ulcer formation in the context of primary varicose veins ( p < 0.001). Additional experiments showed that HHcy could induce endothelial dysfunction and phenotypic switching of vascular smooth muscle cells. Conclusion: Both clinical and experimental findings implicated HHcy as a key factor in the development of venous ulceration. Further research is needed to appraise the effectiveness of HHcy-lowering therapy in the prevention of venous ulcers in patients with varicose veins.

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Section: Discussionsupporting

confidence: 62%

Elevated serum homocysteine levels are associated with the development of chronic venous ulcers

Guo

Wang

et al. 2022

Vasc Med

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“…Moreover, a meta-analysis encompassing 36 studies and involving 60,754 subjects from 19 provinces and municipalities in China found that the prevalence of HHcy was notably higher in men than in women ( 21 ). Furthermore, elevated levels of serum homocysteine have been observed in male patients with hypertension ( 23 ), primary chronic venous disease ( 24 ), and psoriasis ( 25 ). Potential factors contributing to the observed sex-specific variation encompass disparities in muscle mass, estrogen levels, lifestyles, and vitamin levels.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and clinical correlates of hyperhomocysteinemia in Chinese urban population with hypertension

Xu,

Feng,

Zhang

et al. 2024

Front. Endocrinol.

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ContextThe coexistence of hypertension and elevated homocysteine (Hcy) levels has a mutually reinforcing impact on the susceptibility to cardio-cerebrovascular disease.ObjectiveThe aim was to assess the prevalence, clinical correlation, and demographic characteristics of hyperhomocysteinemia (HHcy) within the Chinese urban population with hypertension.MethodsA cohort of 473 individuals with hypertension were selected from four communities in Shenzhen, China. Demographic attributes, clinical profiles, and lifestyle behaviors were gathered and compared between individuals with and without HHcy. A logistic regression model was employed to examine potential factors associated with the prevalence of HHcy. Correlation between Hcy levels and clinical characteristics was assessed through multiple linear regression analysis.ResultsThe prevalence of HHcy in the population with hypertension was 31.3%. In comparison to individuals without HHcy, those with HHcy exhibited a higher proportion of males, a higher prevalence of smoking and alcohol consumption, and a higher proportion of cases with the homozygous (TT) genotype at the MTHFR C677T polymorphism. Moreover, individuals with HHcy had lower levels of folic acid (FA), and lower fruit and vitamin B12 intake. Furthermore, the risk factors for HHcy were male (B = 1.430, OR = 4.179) and MTHFR (TT) (B = 1.086, OR = 2.961). In addition, the multiple linear regression analysis revealed a significant association between Hcy levels and gender (B = -2.784, P = 0.004), MTHFR genotypes (B = 1.410, P = 0.005), and FA levels (B = -0.136, P = 0.030).ConclusionThe high prevalence of HHcy among hypertensive patients in this Chinese urban population underscores the necessity for interventions targeting modifiable risk factors such as dietary choices and lifestyle practices.

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“…An analysis of healthy people demonstrated that serum homocysteine levels are higher in males than in females [ 19 ]. Elevated serum homocysteine levels have been reported in male patients with hypertension, cardiovascular disease, primary chronic venous disease, and glaucomatous disease [ 20 , 21 , 22 , 23 ]. Previous studies also indicate that further factors, such as a surge in blood lead and cadmium levels, could increase homocysteine levels in males [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate

Zhang

Lin

Zhang

et al. 2022

JCM

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Background: Hyperhomocysteinemia has been reported in psoriasis. We investigated the effect of methylenetetrahydrofolate reductase (MTHFR), polymorphism and folic acid supplementation on serum homocysteine levels in psoriasis. Methods: Serum homocysteine levels were detected at baseline and at week 12 in 201 patients who were genotyped with MTHFR rs1801133 without and 93 psoriatic patients with folate supplement. Results: TT genotype carriers of MTHFR rs1801133 had significantly higher serum homocysteine levels at baseline and at week 12, a better PASI 75 response rate at week 8, and a higher PASI 90 response rate at week 12 than the CT and CC genotype carriers. Multiple regression analysis demonstrated that serum homocysteine concentration at baseline was significantly associated with sex, weight, PASI score at baseline, and the rs1801133 genotype. The significant upregulation of serum homocysteine levels after treatment with methotrexate (MTX) was only observed in male CT and CC genotype carriers and female CC genotype carriers. In contrast, folic acid supplementation significantly decreased serum homocysteine levels after MTX treatment but only in male psoriatic patients. Conclusions: The effect of MTX on serum homocysteine levels was associated with the polymorphism of MTHFR rs1801133 and sex. Folic acid supplementation only decreased serum homocysteine levels in male psoriatic patients.

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Serum homocysteine is associated with the severity of primary chronic venous disease

Abstract: Serum homocysteine is positively associated with the severity of primary chronic venous disease and therefore could play a role in promoting chronic venous disease complications.

Cited by 9 publications

References 36 publications

Elevated serum homocysteine levels are associated with the development of chronic venous ulcers

Elevated serum homocysteine levels are associated with the development of chronic venous ulcers

Prevalence and clinical correlates of hyperhomocysteinemia in Chinese urban population with hypertension

MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate

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