This paper aims to discuss the implementation of Outcome-Based Education (OBE) in the relevant ISO 21001 requirements. These requirements include understanding the organization and its context, needs of students and other beneficiaries, actions to address risks and opportunities, delivery and assessment of learning, evaluation, and corrective/improvement actions. The research method examines the requirements of ISO 21001 relevant to the implementation of OBE and provides an example of its application in one of the study programs. The study results show that ISO 21001 in higher education can be used as a management system platform to achieve the desired results under the organization’s vision, mission, and goals and implement OBE. An example of the application shows that the study program carried out the delivery of OBE in a more structured and systematic manner by referring to the requirements in ISO 21001. Structured, the study program uses an input-process-output/outcome approach in managing OBE. Meanwhile, systematic, the study program uses the PDCA cycle to improve OBE performance. Practically, study programs in Indonesia can use the ISO 21001 standard to harmonize the application of Education Standards in the National Standards for Higher Education, especially competency, content, learning process, and assessment. Furthermore, the study program uses the PDCA cycle to continuously meet and improve OBE performance.